Journal Article

DZNE-2021-00371

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.

Malpetti, M. ; Jones, P. S. ; Tsvetanov, K. A. ; Rittman, T. ; van Swieten, J. C. ; Borroni, B. ; Sanchez-Valle, R. ; Moreno, F. ; Laforce, R. ; Graff, C. ; Synofzik, M.DZNE* ; Galimberti, D. ; Masellis, M. ; Tartaglia, M. C. ; Finger, E. ; Vandenberghe, R. ; de Mendonça, A. ; Tagliavini, F. ; Santana, I. ; Ducharme, S. ; Butler, C. R. ; Gerhard, A. ; Levin, J.DZNE* ; Danek, A.Extern* ; Otto, M. ; Frisoni, G. B. ; Ghidoni, R. ; Sorbi, S. ; Heller, C. ; Todd, E. G. ; Bocchetta, M. ; Cash, D. M. ; Convery, R. S. ; Peakman, G. ; Moore, K. M. ; Rohrer, J. D. ; Kievit, R. A. ; Rowe, J. B. (Corresponding author) ; Genfi, G. F. I.

2021
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.12252

Abstract: Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy.Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal changes in apathy, cognition, gray matter volumes, and their relationships were analyzed with latent growth curve modeling.Apathy severity increased over time in presymptomatic carriers, but not in non-carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but not vice versa. Apathy progression was associated with baseline low gray matter volume in frontal and cingulate regions.Apathy is an early marker of FTD-related changes and predicts a subsequent subclinical deterioration of cognition before dementia onset. Apathy may be a modifiable factor in those at risk of FTD.

Keyword(s): Apathy (MeSH) ; Atrophy: pathology (MeSH) ; Brain: pathology (MeSH) ; Cognitive Dysfunction: pathology (MeSH) ; Female (MeSH) ; Frontotemporal Dementia: genetics (MeSH) ; Gray Matter: pathology (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Mutation: genetics (MeSH) ; Prodromal Symptoms (MeSH) ; MRI ; apathy ; cognitive decline ; genetic frontotemporal dementia ; longitudinal design ; presymptomatic carriers

Note: (CC BY)

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Contributing Institute(s):

1. Clinical Dementia Research München (Clinical Dementia Research München)
2. Parkinson Genetics (AG Gasser 1)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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