TY  - JOUR
AU  - Malpetti, Maura
AU  - Jones, P Simon
AU  - Tsvetanov, Kamen A
AU  - Rittman, Timothy
AU  - van Swieten, John C
AU  - Borroni, Barbara
AU  - Sanchez-Valle, Raquel
AU  - Moreno, Fermin
AU  - Laforce, Robert
AU  - Graff, Caroline
AU  - Synofzik, Matthis
AU  - Galimberti, Daniela
AU  - Masellis, Mario
AU  - Tartaglia, Maria Carmela
AU  - Finger, Elizabeth
AU  - Vandenberghe, Rik
AU  - de Mendonça, Alexandre
AU  - Tagliavini, Fabrizio
AU  - Santana, Isabel
AU  - Ducharme, Simon
AU  - Butler, Chris R
AU  - Gerhard, Alexander
AU  - Levin, Johannes
AU  - Danek, Adrian
AU  - Otto, Markus
AU  - Frisoni, Giovanni B
AU  - Ghidoni, Roberta
AU  - Sorbi, Sandro
AU  - Heller, Carolin
AU  - Todd, Emily G
AU  - Bocchetta, Martina
AU  - Cash, David M
AU  - Convery, Rhian S
AU  - Peakman, Georgia
AU  - Moore, Katrina M
AU  - Rohrer, Jonathan D
AU  - Kievit, Rogier A
AU  - Rowe, James B
AU  - Genfi, Genetic Ftd Initiative
TI  - Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.
JO  - Alzheimer's and dementia
VL  - 17
IS  - 6
SN  - 1552-5279
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2021-00371
SP  - 969 - 983
PY  - 2021
N1  - (CC BY)
AB  - Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy.Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal changes in apathy, cognition, gray matter volumes, and their relationships were analyzed with latent growth curve modeling.Apathy severity increased over time in presymptomatic carriers, but not in non-carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but not vice versa. Apathy progression was associated with baseline low gray matter volume in frontal and cingulate regions.Apathy is an early marker of FTD-related changes and predicts a subsequent subclinical deterioration of cognition before dementia onset. Apathy may be a modifiable factor in those at risk of FTD.
KW  - Apathy
KW  - Atrophy: pathology
KW  - Brain: pathology
KW  - Cognitive Dysfunction: pathology
KW  - Female
KW  - Frontotemporal Dementia: genetics
KW  - Gray Matter: pathology
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Mutation: genetics
KW  - Prodromal Symptoms
KW  - MRI (Other)
KW  - apathy (Other)
KW  - cognitive decline (Other)
KW  - genetic frontotemporal dementia (Other)
KW  - longitudinal design (Other)
KW  - presymptomatic carriers (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC8247340
C6  - pmid:33316852
DO  - DOI:10.1002/alz.12252
UR  - https://pub.dzne.de/record/154791
ER  -