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@ARTICLE{Malpetti:154791,
      author       = {Malpetti, Maura and Jones, P Simon and Tsvetanov, Kamen A
                      and Rittman, Timothy and van Swieten, John C and Borroni,
                      Barbara and Sanchez-Valle, Raquel and Moreno, Fermin and
                      Laforce, Robert and Graff, Caroline and Synofzik, Matthis
                      and Galimberti, Daniela and Masellis, Mario and Tartaglia,
                      Maria Carmela and Finger, Elizabeth and Vandenberghe, Rik
                      and de Mendonça, Alexandre and Tagliavini, Fabrizio and
                      Santana, Isabel and Ducharme, Simon and Butler, Chris R and
                      Gerhard, Alexander and Levin, Johannes and Danek, Adrian and
                      Otto, Markus and Frisoni, Giovanni B and Ghidoni, Roberta
                      and Sorbi, Sandro and Heller, Carolin and Todd, Emily G and
                      Bocchetta, Martina and Cash, David M and Convery, Rhian S
                      and Peakman, Georgia and Moore, Katrina M and Rohrer,
                      Jonathan D and Kievit, Rogier A and Rowe, James B and Genfi,
                      Genetic Ftd Initiative},
      title        = {{A}pathy in presymptomatic genetic frontotemporal dementia
                      predicts cognitive decline and is driven by structural brain
                      changes.},
      journal      = {Alzheimer's and dementia},
      volume       = {17},
      number       = {6},
      issn         = {1552-5279},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-00371},
      pages        = {969 - 983},
      year         = {2021},
      note         = {(CC BY)},
      abstract     = {Apathy adversely affects prognosis and survival of patients
                      with frontotemporal dementia (FTD). We test whether apathy
                      develops in presymptomatic genetic FTD, and is associated
                      with cognitive decline and brain atrophy.Presymptomatic
                      carriers of MAPT, GRN or C9orf72 mutations (N = 304), and
                      relatives without mutations (N = 296) underwent clinical
                      assessments and MRI at baseline, and annually for 2 years.
                      Longitudinal changes in apathy, cognition, gray matter
                      volumes, and their relationships were analyzed with latent
                      growth curve modeling.Apathy severity increased over time in
                      presymptomatic carriers, but not in non-carriers. In
                      presymptomatic carriers, baseline apathy predicted cognitive
                      decline over two years, but not vice versa. Apathy
                      progression was associated with baseline low gray matter
                      volume in frontal and cingulate regions.Apathy is an early
                      marker of FTD-related changes and predicts a subsequent
                      subclinical deterioration of cognition before dementia
                      onset. Apathy may be a modifiable factor in those at risk of
                      FTD.},
      keywords     = {Apathy / Atrophy: pathology / Brain: pathology / Cognitive
                      Dysfunction: pathology / Female / Frontotemporal Dementia:
                      genetics / Gray Matter: pathology / Humans / Magnetic
                      Resonance Imaging / Male / Middle Aged / Mutation: genetics
                      / Prodromal Symptoms / MRI (Other) / apathy (Other) /
                      cognitive decline (Other) / genetic frontotemporal dementia
                      (Other) / longitudinal design (Other) / presymptomatic
                      carriers (Other)},
      cin          = {Clinical Dementia Research München / AG Gasser 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016 / I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8247340},
      pubmed       = {pmid:33316852},
      doi          = {10.1002/alz.12252},
      url          = {https://pub.dzne.de/record/154791},
}