Home > Publications Database > Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes. > print

001     154791
005     20240320115507.0
024 7 _ |a pmc:PMC8247340
|2 pmc
024 7 _ |a 10.1002/alz.12252
|2 doi
024 7 _ |a pmid:33316852
|2 pmid
024 7 _ |a 1552-5260
|2 ISSN
024 7 _ |a 1552-5279
|2 ISSN
024 7 _ |a altmetric:96002765
|2 altmetric
037 _ _ |a DZNE-2021-00371
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Malpetti, Maura
|b 0
245 _ _ |a Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.
260 _ _ |a Hoboken, NJ
|c 2021
|b Wiley
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1654856190_23358
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a (CC BY)
520 _ _ |a Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy.Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal changes in apathy, cognition, gray matter volumes, and their relationships were analyzed with latent growth curve modeling.Apathy severity increased over time in presymptomatic carriers, but not in non-carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but not vice versa. Apathy progression was associated with baseline low gray matter volume in frontal and cingulate regions.Apathy is an early marker of FTD-related changes and predicts a subsequent subclinical deterioration of cognition before dementia onset. Apathy may be a modifiable factor in those at risk of FTD.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a MRI
|2 Other
650 _ 7 |a apathy
|2 Other
650 _ 7 |a cognitive decline
|2 Other
650 _ 7 |a genetic frontotemporal dementia
|2 Other
650 _ 7 |a longitudinal design
|2 Other
650 _ 7 |a presymptomatic carriers
|2 Other
650 _ 2 |a Apathy
|2 MeSH
650 _ 2 |a Atrophy: pathology
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: pathology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: genetics
|2 MeSH
650 _ 2 |a Gray Matter: pathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Mutation: genetics
|2 MeSH
650 _ 2 |a Prodromal Symptoms
|2 MeSH
700 1 _ |a Jones, P Simon
|b 1
700 1 _ |a Tsvetanov, Kamen A
|b 2
700 1 _ |a Rittman, Timothy
|b 3
700 1 _ |a van Swieten, John C
|b 4
700 1 _ |a Borroni, Barbara
|b 5
700 1 _ |a Sanchez-Valle, Raquel
|b 6
700 1 _ |a Moreno, Fermin
|b 7
700 1 _ |a Laforce, Robert
|b 8
700 1 _ |a Graff, Caroline
|b 9
700 1 _ |a Synofzik, Matthis
|0 P:(DE-2719)2811275
|b 10
700 1 _ |a Galimberti, Daniela
|b 11
700 1 _ |a Masellis, Mario
|b 12
700 1 _ |a Tartaglia, Maria Carmela
|b 13
700 1 _ |a Finger, Elizabeth
|b 14
700 1 _ |a Vandenberghe, Rik
|b 15
700 1 _ |a de Mendonça, Alexandre
|b 16
700 1 _ |a Tagliavini, Fabrizio
|b 17
700 1 _ |a Santana, Isabel
|b 18
700 1 _ |a Ducharme, Simon
|b 19
700 1 _ |a Butler, Chris R
|b 20
700 1 _ |a Gerhard, Alexander
|b 21
700 1 _ |a Levin, Johannes
|0 P:(DE-2719)2811659
|b 22
700 1 _ |a Danek, Adrian
|0 P:(DE-HGF)0
|b 23
700 1 _ |a Otto, Markus
|b 24
700 1 _ |a Frisoni, Giovanni B
|b 25
700 1 _ |a Ghidoni, Roberta
|b 26
700 1 _ |a Sorbi, Sandro
|b 27
700 1 _ |a Heller, Carolin
|b 28
700 1 _ |a Todd, Emily G
|b 29
700 1 _ |a Bocchetta, Martina
|b 30
700 1 _ |a Cash, David M
|b 31
700 1 _ |a Convery, Rhian S
|b 32
700 1 _ |a Peakman, Georgia
|b 33
700 1 _ |a Moore, Katrina M
|b 34
700 1 _ |a Rohrer, Jonathan D
|b 35
700 1 _ |a Kievit, Rogier A
|b 36
700 1 _ |a Rowe, James B
|0 P:(DE-HGF)0
|b 37
|e Corresponding author
700 1 _ |a Genfi, Genetic Ftd Initiative
|b 38
773 _ _ |a 10.1002/alz.12252
|g Vol. 17, no. 6, p. 969 - 983
|0 PERI:(DE-600)2201940-6
|n 6
|p 969 - 983
|t Alzheimer's and dementia
|v 17
|y 2021
|x 1552-5279
856 4 _ |u https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12252
856 4 _ |u https://pub.dzne.de/record/154791/files/DZNE-2021-00371.pdf
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/154791/files/DZNE-2021-00371.pdf?subformat=pdfa
|x pdfa
|y OpenAccess
909 C O |o oai:pub.dzne.de:154791
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 10
|6 P:(DE-2719)2811275
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 22
|6 P:(DE-2719)2811659
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 23
|6 P:(DE-HGF)0
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-353
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
913 0 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-344
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2021
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2022-11-11
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2022-11-11
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a IF >= 15
|0 StatID:(DE-HGF)9915
|2 StatID
|b ALZHEIMERS DEMENT : 2021
|d 2022-11-11
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b ALZHEIMERS DEMENT : 2021
|d 2022-11-11
915 _ _ |a DEAL Wiley
|0 StatID:(DE-HGF)3001
|2 StatID
|d 2021-01-28
|w ger
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-01-28
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2022-11-11
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-01-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1110
|2 StatID
|b Current Contents - Clinical Medicine
|d 2022-11-11
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2022-11-11
920 _ _ |l yes
920 1 _ |0 I:(DE-2719)1111016
|k Clinical Dementia Research München
|l Clinical Dementia Research München
|x 0
920 1 _ |0 I:(DE-2719)1210000
|k AG Gasser 1
|l Parkinson Genetics
|x 1
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1111016
980 _ _ |a I:(DE-2719)1210000
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21