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@ARTICLE{Manera:154809,
      author       = {Manera, Ana L and Dadar, Mahsa and Van Swieten, John
                      Cornelis and Borroni, Barbara and Sanchez-Valle, Raquel and
                      Moreno, Fermin and Laforce, Robert and Graff, Caroline and
                      Synofzik, Matthis and Galimberti, Daniela and Rowe, James
                      Benedict and Masellis, Mario and Tartaglia, Maria Carmela
                      and Finger, Elizabeth and Vandenberghe, Rik and de Mendonca,
                      Alexandre and Tagliavini, Fabrizio and Santana, Isabel and
                      Butler, Christopher R and Gerhard, Alex and Danek, Adrian
                      and Levin, Johannes and Otto, Markus and Frisoni, Giovanni
                      and Ghidoni, Roberta and Sorbi, Sandro and Rohrer, Jonathan
                      Daniel and Ducharme, Simon and Collins, D Louis and Rosen,
                      Howard and Dickerson, Bradford C and Domoto-Reilly, Kimoko
                      and Knopman, David and Boeve, Bradley F and Boxer, Adam L
                      and Kornak, John and Miller, Bruce L and Seeley, William W
                      and Gorno-Tempini, Maria-Luisa and McGinnis, Scott and
                      Mandelli, Maria Luisa and Afonso, Sónia and Almeida, Maria
                      Rosario and Anderl-Straub, Sarah and Andersson, Christin and
                      Antonell, Anna and Archetti, Silvana and Arighi, Andrea and
                      Balasa, Mircea and Barandiaran, Myriam and Bargalló, Nuria
                      and Bartha, Robart and Bender, Benjamin and Benussi, Alberto
                      and Benussi, Luisa and Bessi, Valentina and Binetti,
                      Giuliano and Black, Sandra and Bocchetta, Martina and
                      Borrego-Ecija, Sergi and Bras, Jose and Bruffaerts, Rose and
                      Caroppo, Paola and Cash, David and Castelo-Branco, Miguel
                      and Convery, Rhian and Cope, Thomas and Cosseddu, Maura and
                      Arriba, María de and Fede, Giuseppe Di and Díaz, Zigor and
                      Duro, Diana and Fenoglio, Chiara and Ferrari, Camilla and
                      Ferreira, Carlos and Ferreira, Catarina B and Flanagan, Toby
                      and Fox, Nick and Freedman, Morris and Fumagalli, Giorgio
                      and Gabilondo, Alazne and Gasparotti, Roberto and Gauthier,
                      Serge and Gazzina, Stefano and Giaccone, Giorgio and
                      Gorostidi, Ana and Greaves, Caroline and Guerreiro, Rita and
                      Heller, Carolin and Hoegen, Tobias and Indakoetxea, Begoña
                      and Jelic, Vesna and Jiskoot, Lize and Karnath, Hans-Otto
                      and Keren, Ron and Leitão, Maria João and Lladó, Albert
                      and Lombardi, Gemma and Loosli, Sandra and Maruta, Carolina
                      and Mead, Simon and Meeter, Lieke and Miltenberger, Gabriel
                      and Minkelen, Rick van and Mitchell, Sara and Moore, Katrina
                      M and Nacmias, Benedetta and Neason, Mollie and Nicholas,
                      Jennifer and Öijerstedt, Linn and Olives, Jaume and
                      Ourselin, Sebastien and Padovani, Alessandro and Panman,
                      Jessica and Papma, Janne and Peakman, Georgia and Piaceri,
                      Irene and Pievani, Michela and Pijnenburg, Yolande and
                      Polito, Cristina and Premi, Enrico and Prioni, Sara and
                      Prix, Catharina and Rademakers, Rosa and Redaelli, Veronica
                      and Rittman, Tim and Rogaeva, Ekaterina and Rosa-Neto, Pedro
                      and Rossi, Giacomina and Rossor, Martin and Santiago,
                      Beatriz and Scarpini, Elio and Schönecker, Sonja and
                      Semler, Elisa and Shafei, Rachelle and Shoesmith, Christen
                      and Tábuas-Pereira, Miguel and Tainta, Mikel and Taipa,
                      Ricardo and Tang-Wai, David and Thomas, David L and
                      Thonberg, Hakan and Timberlake, Carolyn and Tiraboschi,
                      Pietro and Todd, Emily and Vandamme, Philip and
                      Vandenbulcke, Mathieu and Veldsman, Michele and Verdelho,
                      Ana and Villanua, Jorge and Warren, Jason and Wilke, Carlo
                      and Woollacott, Ione and Wlasich, Elisabeth and Zetterberg,
                      Henrik and Zulaica, Miren},
      collaboration = {investigators, FTLDNI and Consortium, GENFI},
      title        = {{MRI} data-driven algorithm for the diagnosis of
                      behavioural variant frontotemporal dementia.},
      journal      = {Journal of neurology, neurosurgery, and psychiatry},
      volume       = {92},
      number       = {6},
      issn         = {1468-330X},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {DZNE-2021-00387},
      pages        = {608 - 616},
      year         = {2021},
      abstract     = {Structural brain imaging is paramount for the diagnosis of
                      behavioural variant of frontotemporal dementia (bvFTD), but
                      it has low sensitivity leading to erroneous or late
                      diagnosis.A total of 515 subjects from two different bvFTD
                      cohorts (training and independent validation cohorts) were
                      used to perform voxel-wise morphometric analysis to identify
                      regions with significant differences between bvFTD and
                      controls. A random forest classifier was used to
                      individually predict bvFTD from deformation-based
                      morphometry differences in isolation and together with
                      semantic fluency. Tenfold cross validation was used to
                      assess the performance of the classifier within the training
                      cohort. A second held-out cohort of genetically confirmed
                      bvFTD cases was used for additional validation.Average
                      10-fold cross-validation accuracy was $89\%$ $(82\%$
                      sensitivity, $93\%$ specificity) using only MRI and $94\%$
                      $(89\%$ sensitivity, $98\%$ specificity) with the addition
                      of semantic fluency. In the separate validation cohort of
                      definite bvFTD, accuracy was $88\%$ $(81\%$ sensitivity,
                      $92\%$ specificity) with MRI and $91\%$ $(79\%$ sensitivity,
                      $96\%$ specificity) with added semantic fluency scores.Our
                      results show that structural MRI and semantic fluency can
                      accurately predict bvFTD at the individual subject level
                      within a completely independent validation cohort coming
                      from a different and independent database.},
      cin          = {Clinical Dementia Research München},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33722819},
      doi          = {10.1136/jnnp-2020-324106},
      url          = {https://pub.dzne.de/record/154809},
}