guest ::
| Home > Publications Database > MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementia. > print |
| Home > Publications Database > MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementia. > print |
| 001 | 154809 | ||
| 005 | 20230915092317.0 | ||
| 024 | 7 | _ | |a 10.1136/jnnp-2020-324106 |2 doi |
| 024 | 7 | _ | |a pmid:33722819 |2 pmid |
| 024 | 7 | _ | |a 0022-3050 |2 ISSN |
| 024 | 7 | _ | |a 0266-8637 |2 ISSN |
| 024 | 7 | _ | |a 0368-329X |2 ISSN |
| 024 | 7 | _ | |a 1468-330X |2 ISSN |
| 024 | 7 | _ | |a altmetric:101700147 |2 altmetric |
| 037 | _ | _ | |a DZNE-2021-00387 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Manera, Ana L |0 0000-0003-1639-6858 |b 0 |
| 245 | _ | _ | |a MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementia. |
| 260 | _ | _ | |a London |c 2021 |b BMJ Publishing Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1625840306_15373 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Structural brain imaging is paramount for the diagnosis of behavioural variant of frontotemporal dementia (bvFTD), but it has low sensitivity leading to erroneous or late diagnosis.A total of 515 subjects from two different bvFTD cohorts (training and independent validation cohorts) were used to perform voxel-wise morphometric analysis to identify regions with significant differences between bvFTD and controls. A random forest classifier was used to individually predict bvFTD from deformation-based morphometry differences in isolation and together with semantic fluency. Tenfold cross validation was used to assess the performance of the classifier within the training cohort. A second held-out cohort of genetically confirmed bvFTD cases was used for additional validation.Average 10-fold cross-validation accuracy was 89% (82% sensitivity, 93% specificity) using only MRI and 94% (89% sensitivity, 98% specificity) with the addition of semantic fluency. In the separate validation cohort of definite bvFTD, accuracy was 88% (81% sensitivity, 92% specificity) with MRI and 91% (79% sensitivity, 96% specificity) with added semantic fluency scores.Our results show that structural MRI and semantic fluency can accurately predict bvFTD at the individual subject level within a completely independent validation cohort coming from a different and independent database. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |x 0 |f POF IV |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 700 | 1 | _ | |a Dadar, Mahsa |0 0000-0003-4008-2672 |b 1 |
| 700 | 1 | _ | |a Van Swieten, John Cornelis |0 0000-0001-6278-6844 |b 2 |
| 700 | 1 | _ | |a Borroni, Barbara |0 0000-0001-9340-9814 |b 3 |
| 700 | 1 | _ | |a Sanchez-Valle, Raquel |b 4 |
| 700 | 1 | _ | |a Moreno, Fermin |b 5 |
| 700 | 1 | _ | |a Laforce, Robert |b 6 |
| 700 | 1 | _ | |a Graff, Caroline |b 7 |
| 700 | 1 | _ | |a Synofzik, Matthis |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Galimberti, Daniela |0 0000-0002-9284-5953 |b 9 |
| 700 | 1 | _ | |a Rowe, James Benedict |0 0000-0001-7216-8679 |b 10 |
| 700 | 1 | _ | |a Masellis, Mario |b 11 |
| 700 | 1 | _ | |a Tartaglia, Maria Carmela |b 12 |
| 700 | 1 | _ | |a Finger, Elizabeth |0 0000-0003-4461-7427 |b 13 |
| 700 | 1 | _ | |a Vandenberghe, Rik |b 14 |
| 700 | 1 | _ | |a de Mendonca, Alexandre |b 15 |
| 700 | 1 | _ | |a Tagliavini, Fabrizio |b 16 |
| 700 | 1 | _ | |a Santana, Isabel |b 17 |
| 700 | 1 | _ | |a Butler, Christopher R |b 18 |
| 700 | 1 | _ | |a Gerhard, Alex |b 19 |
| 700 | 1 | _ | |a Danek, Adrian |0 P:(DE-2719)2810712 |b 20 |u dzne |
| 700 | 1 | _ | |a Levin, Johannes |0 P:(DE-2719)2811659 |b 21 |u dzne |
| 700 | 1 | _ | |a Otto, Markus |0 0000-0002-6647-5944 |b 22 |
| 700 | 1 | _ | |a Frisoni, Giovanni |b 23 |
| 700 | 1 | _ | |a Ghidoni, Roberta |b 24 |
| 700 | 1 | _ | |a Sorbi, Sandro |b 25 |
| 700 | 1 | _ | |a Rohrer, Jonathan Daniel |0 0000-0002-6155-8417 |b 26 |
| 700 | 1 | _ | |a Ducharme, Simon |0 0000-0002-7309-1113 |b 27 |
| 700 | 1 | _ | |a Collins, D Louis |b 28 |
| 700 | 1 | _ | |a investigators, FTLDNI |b 29 |e Collaboration Author |
| 700 | 1 | _ | |a Consortium, GENFI |b 30 |e Collaboration Author |
| 700 | 1 | _ | |a Rosen, Howard |b 31 |
| 700 | 1 | _ | |a Dickerson, Bradford C |b 32 |
| 700 | 1 | _ | |a Domoto-Reilly, Kimoko |b 33 |
| 700 | 1 | _ | |a Knopman, David |0 P:(DE-HGF)0 |b 34 |
| 700 | 1 | _ | |a Boeve, Bradley F |b 35 |
| 700 | 1 | _ | |a Boxer, Adam L |b 36 |
| 700 | 1 | _ | |a Kornak, John |b 37 |
| 700 | 1 | _ | |a Miller, Bruce L |b 38 |
| 700 | 1 | _ | |a Seeley, William W |b 39 |
| 700 | 1 | _ | |a Gorno-Tempini, Maria-Luisa |b 40 |
| 700 | 1 | _ | |a McGinnis, Scott |b 41 |
| 700 | 1 | _ | |a Mandelli, Maria Luisa |b 42 |
| 700 | 1 | _ | |a Afonso, Sónia |b 43 |
| 700 | 1 | _ | |a Almeida, Maria Rosario |b 44 |
| 700 | 1 | _ | |a Anderl-Straub, Sarah |b 45 |
| 700 | 1 | _ | |a Andersson, Christin |b 46 |
| 700 | 1 | _ | |a Antonell, Anna |b 47 |
| 700 | 1 | _ | |a Archetti, Silvana |b 48 |
| 700 | 1 | _ | |a Arighi, Andrea |b 49 |
| 700 | 1 | _ | |a Balasa, Mircea |b 50 |
| 700 | 1 | _ | |a Barandiaran, Myriam |b 51 |
| 700 | 1 | _ | |a Bargalló, Nuria |b 52 |
| 700 | 1 | _ | |a Bartha, Robart |b 53 |
| 700 | 1 | _ | |a Bender, Benjamin |b 54 |
| 700 | 1 | _ | |a Benussi, Alberto |b 55 |
| 700 | 1 | _ | |a Benussi, Luisa |b 56 |
| 700 | 1 | _ | |a Bessi, Valentina |b 57 |
| 700 | 1 | _ | |a Binetti, Giuliano |b 58 |
| 700 | 1 | _ | |a Black, Sandra |b 59 |
| 700 | 1 | _ | |a Bocchetta, Martina |b 60 |
| 700 | 1 | _ | |a Borrego-Ecija, Sergi |b 61 |
| 700 | 1 | _ | |a Bras, Jose |b 62 |
| 700 | 1 | _ | |a Bruffaerts, Rose |b 63 |
| 700 | 1 | _ | |a Caroppo, Paola |b 64 |
| 700 | 1 | _ | |a Cash, David |b 65 |
| 700 | 1 | _ | |a Castelo-Branco, Miguel |b 66 |
| 700 | 1 | _ | |a Convery, Rhian |b 67 |
| 700 | 1 | _ | |a Cope, Thomas |b 68 |
| 700 | 1 | _ | |a Cosseddu, Maura |b 69 |
| 700 | 1 | _ | |a Arriba, María de |b 70 |
| 700 | 1 | _ | |a Fede, Giuseppe Di |b 71 |
| 700 | 1 | _ | |a Díaz, Zigor |b 72 |
| 700 | 1 | _ | |a Duro, Diana |b 73 |
| 700 | 1 | _ | |a Fenoglio, Chiara |b 74 |
| 700 | 1 | _ | |a Ferrari, Camilla |b 75 |
| 700 | 1 | _ | |a Ferreira, Carlos |b 76 |
| 700 | 1 | _ | |a Ferreira, Catarina B |b 77 |
| 700 | 1 | _ | |a Flanagan, Toby |b 78 |
| 700 | 1 | _ | |a Fox, Nick |b 79 |
| 700 | 1 | _ | |a Freedman, Morris |b 80 |
| 700 | 1 | _ | |a Fumagalli, Giorgio |b 81 |
| 700 | 1 | _ | |a Gabilondo, Alazne |b 82 |
| 700 | 1 | _ | |a Gasparotti, Roberto |b 83 |
| 700 | 1 | _ | |a Gauthier, Serge |b 84 |
| 700 | 1 | _ | |a Gazzina, Stefano |b 85 |
| 700 | 1 | _ | |a Giaccone, Giorgio |b 86 |
| 700 | 1 | _ | |a Gorostidi, Ana |b 87 |
| 700 | 1 | _ | |a Greaves, Caroline |b 88 |
| 700 | 1 | _ | |a Guerreiro, Rita |b 89 |
| 700 | 1 | _ | |a Heller, Carolin |b 90 |
| 700 | 1 | _ | |a Hoegen, Tobias |b 91 |
| 700 | 1 | _ | |a Indakoetxea, Begoña |b 92 |
| 700 | 1 | _ | |a Jelic, Vesna |b 93 |
| 700 | 1 | _ | |a Jiskoot, Lize |b 94 |
| 700 | 1 | _ | |a Karnath, Hans-Otto |0 P:(DE-HGF)0 |b 95 |
| 700 | 1 | _ | |a Keren, Ron |b 96 |
| 700 | 1 | _ | |a Leitão, Maria João |b 97 |
| 700 | 1 | _ | |a Lladó, Albert |b 98 |
| 700 | 1 | _ | |a Lombardi, Gemma |b 99 |
| 700 | 1 | _ | |a Loosli, Sandra |b 100 |
| 700 | 1 | _ | |a Maruta, Carolina |b 101 |
| 700 | 1 | _ | |a Mead, Simon |b 102 |
| 700 | 1 | _ | |a Meeter, Lieke |b 103 |
| 700 | 1 | _ | |a Miltenberger, Gabriel |b 104 |
| 700 | 1 | _ | |a Minkelen, Rick van |b 105 |
| 700 | 1 | _ | |a Mitchell, Sara |b 106 |
| 700 | 1 | _ | |a Moore, Katrina M |b 107 |
| 700 | 1 | _ | |a Nacmias, Benedetta |b 108 |
| 700 | 1 | _ | |a Neason, Mollie |b 109 |
| 700 | 1 | _ | |a Nicholas, Jennifer |b 110 |
| 700 | 1 | _ | |a Öijerstedt, Linn |b 111 |
| 700 | 1 | _ | |a Olives, Jaume |b 112 |
| 700 | 1 | _ | |a Ourselin, Sebastien |b 113 |
| 700 | 1 | _ | |a Padovani, Alessandro |b 114 |
| 700 | 1 | _ | |a Panman, Jessica |b 115 |
| 700 | 1 | _ | |a Papma, Janne |b 116 |
| 700 | 1 | _ | |a Peakman, Georgia |b 117 |
| 700 | 1 | _ | |a Piaceri, Irene |b 118 |
| 700 | 1 | _ | |a Pievani, Michela |b 119 |
| 700 | 1 | _ | |a Pijnenburg, Yolande |b 120 |
| 700 | 1 | _ | |a Polito, Cristina |b 121 |
| 700 | 1 | _ | |a Premi, Enrico |b 122 |
| 700 | 1 | _ | |a Prioni, Sara |b 123 |
| 700 | 1 | _ | |a Prix, Catharina |b 124 |
| 700 | 1 | _ | |a Rademakers, Rosa |b 125 |
| 700 | 1 | _ | |a Redaelli, Veronica |b 126 |
| 700 | 1 | _ | |a Rittman, Tim |b 127 |
| 700 | 1 | _ | |a Rogaeva, Ekaterina |b 128 |
| 700 | 1 | _ | |a Rosa-Neto, Pedro |b 129 |
| 700 | 1 | _ | |a Rossi, Giacomina |b 130 |
| 700 | 1 | _ | |a Rossor, Martin |b 131 |
| 700 | 1 | _ | |a Santiago, Beatriz |b 132 |
| 700 | 1 | _ | |a Scarpini, Elio |b 133 |
| 700 | 1 | _ | |a Schönecker, Sonja |b 134 |
| 700 | 1 | _ | |a Semler, Elisa |b 135 |
| 700 | 1 | _ | |a Shafei, Rachelle |b 136 |
| 700 | 1 | _ | |a Shoesmith, Christen |b 137 |
| 700 | 1 | _ | |a Tábuas-Pereira, Miguel |b 138 |
| 700 | 1 | _ | |a Tainta, Mikel |b 139 |
| 700 | 1 | _ | |a Taipa, Ricardo |b 140 |
| 700 | 1 | _ | |a Tang-Wai, David |b 141 |
| 700 | 1 | _ | |a Thomas, David L |b 142 |
| 700 | 1 | _ | |a Thonberg, Hakan |b 143 |
| 700 | 1 | _ | |a Timberlake, Carolyn |b 144 |
| 700 | 1 | _ | |a Tiraboschi, Pietro |b 145 |
| 700 | 1 | _ | |a Todd, Emily |b 146 |
| 700 | 1 | _ | |a Vandamme, Philip |b 147 |
| 700 | 1 | _ | |a Vandenbulcke, Mathieu |b 148 |
| 700 | 1 | _ | |a Veldsman, Michele |b 149 |
| 700 | 1 | _ | |a Verdelho, Ana |b 150 |
| 700 | 1 | _ | |a Villanua, Jorge |b 151 |
| 700 | 1 | _ | |a Warren, Jason |b 152 |
| 700 | 1 | _ | |a Wilke, Carlo |0 P:(DE-HGF)0 |b 153 |
| 700 | 1 | _ | |a Woollacott, Ione |b 154 |
| 700 | 1 | _ | |a Wlasich, Elisabeth |b 155 |
| 700 | 1 | _ | |a Zetterberg, Henrik |b 156 |
| 700 | 1 | _ | |a Zulaica, Miren |b 157 |
| 773 | _ | _ | |a 10.1136/jnnp-2020-324106 |g Vol. 92, no. 6, p. 608 - 616 |0 PERI:(DE-600)1480429-3 |n 6 |p 608 - 616 |t Journal of neurology, neurosurgery, and psychiatry |v 92 |y 2021 |x 1468-330X |
| 909 | C | O | |o oai:pub.dzne.de:154809 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 20 |6 P:(DE-2719)2810712 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 21 |6 P:(DE-2719)2811659 |
| 913 | 0 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-344 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-353 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-27 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-01-27 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-27 |
| 915 | _ | _ | |a National-Konsortium |0 StatID:(DE-HGF)0430 |2 StatID |d 2022-11-23 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-23 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J NEUROL NEUROSUR PS : 2021 |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-23 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-23 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b J NEUROL NEUROSUR PS : 2021 |d 2022-11-23 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-2719)1111016 |k Clinical Dementia Research München |l Clinical Dementia Research München |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1111016 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|