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000155161 245__ $$aFrequency and phenotype of thalamic aphasia.
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000155161 520__ $$aAphasia is a recognized presenting symptom of thalamic lesions. Little is known regarding its frequency and phenotype. We examined the frequency of thalamic aphasia following Isolated Acute unilateral ischemic Lesions in the Thalamus (IALT) with respect to lesion location. Furthermore, we characterized thalamic aphasia according to affected language domains and severity.Fifty-two patients with IALT were analyzed [44% female, median age: 73 years (IQR: 60-79)]. Lesion location was determined using 3-Tesla magnetic resonance imaging and categorized as anterior, posterior, paramedian or inferolateral. Standardized language assessment was performed using the validated Aphasia checklist (ACL) directly after symptom onset. Aphasia was defined as an ACL sum score of < 135 (range: 0-148).Of 52 patients, 23 (44%) fulfilled the ACL diagnostic criteria for aphasia, including nearly all lesion locations and both sides. The average ACL sum score was 132 ± 11 (range: 98-147). Aphasia was characterized by deficits within domains of complex understanding of speech and verbal fluency. Patients with left anterior IALT were most severely affected, having significantly lower ACL scores than all other patients (117 ± 13 vs. 135 ± 8; p < 0.001). In particular, aphasia in patients with left anterior IALT was characterized by significantly worse performance in the rating of verbal communication, verbal fluency, and naming (all p ≤ 0.001).Aphasia occurs in almost half of patients with focal thalamic lesions. Thalamic aphasia is not confined to one predefined thalamic lesion location, but language deficits are particularly pronounced in patients with left anterior IALT presenting with a distinct pattern.
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000155161 650_7 $$2Other$$aAphasia
000155161 650_7 $$2Other$$aLanguage
000155161 650_7 $$2Other$$aStroke
000155161 650_7 $$2Other$$aThalamus
000155161 650_2 $$2MeSH$$aAged
000155161 650_2 $$2MeSH$$aAphasia: etiology
000155161 650_2 $$2MeSH$$aFemale
000155161 650_2 $$2MeSH$$aHumans
000155161 650_2 $$2MeSH$$aLanguage
000155161 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000155161 650_2 $$2MeSH$$aMale
000155161 650_2 $$2MeSH$$aPhenotype
000155161 650_2 $$2MeSH$$aSpeech
000155161 650_2 $$2MeSH$$aStroke
000155161 650_2 $$2MeSH$$aThalamus: diagnostic imaging
000155161 7001_ $$00000-0002-2855-0755$$aFritsch, Merve$$b1
000155161 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b2
000155161 7001_ $$0P:(DE-HGF)0$$aUdke, Birgit$$b3
000155161 7001_ $$0P:(DE-2719)9000234$$aNolte, Christian$$b4$$eLast author
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