Journal Article

DZNE-2021-00482

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Frequency and phenotype of thalamic aphasia.

Rangus, I. ; Fritsch, M. ; Endres, M.DZNE* ; Udke, B. ; Nolte, C. (Last author)DZNE*

2022
Springer Berlin

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Please use a persistent id in citations: doi:10.1007/s00415-021-10640-4

Abstract: Aphasia is a recognized presenting symptom of thalamic lesions. Little is known regarding its frequency and phenotype. We examined the frequency of thalamic aphasia following Isolated Acute unilateral ischemic Lesions in the Thalamus (IALT) with respect to lesion location. Furthermore, we characterized thalamic aphasia according to affected language domains and severity.Fifty-two patients with IALT were analyzed [44% female, median age: 73 years (IQR: 60-79)]. Lesion location was determined using 3-Tesla magnetic resonance imaging and categorized as anterior, posterior, paramedian or inferolateral. Standardized language assessment was performed using the validated Aphasia checklist (ACL) directly after symptom onset. Aphasia was defined as an ACL sum score of < 135 (range: 0-148).Of 52 patients, 23 (44%) fulfilled the ACL diagnostic criteria for aphasia, including nearly all lesion locations and both sides. The average ACL sum score was 132 ± 11 (range: 98-147). Aphasia was characterized by deficits within domains of complex understanding of speech and verbal fluency. Patients with left anterior IALT were most severely affected, having significantly lower ACL scores than all other patients (117 ± 13 vs. 135 ± 8; p < 0.001). In particular, aphasia in patients with left anterior IALT was characterized by significantly worse performance in the rating of verbal communication, verbal fluency, and naming (all p ≤ 0.001).Aphasia occurs in almost half of patients with focal thalamic lesions. Thalamic aphasia is not confined to one predefined thalamic lesion location, but language deficits are particularly pronounced in patients with left anterior IALT presenting with a distinct pattern.

Keyword(s): Aged (MeSH) ; Aphasia: etiology (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Language (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Phenotype (MeSH) ; Speech (MeSH) ; Stroke (MeSH) ; Thalamus: diagnostic imaging (MeSH) ; Aphasia ; Language ; Stroke ; Thalamus

Note: ISSN 1432-1459 not unique: **2 hits**.(CC BY)

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Contributing Institute(s):

1. Coordinator of Clinical Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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