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@ARTICLE{Rangus:155161,
      author       = {Rangus, Ida and Fritsch, Merve and Endres, Matthias and
                      Udke, Birgit and Nolte, Christian},
      title        = {{F}requency and phenotype of thalamic aphasia.},
      journal      = {Journal of neurology},
      volume       = {269},
      number       = {1},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DZNE-2021-00482},
      pages        = {368-376},
      year         = {2022},
      note         = {ISSN 1432-1459 not unique: **2 hits**.(CC BY)},
      abstract     = {Aphasia is a recognized presenting symptom of thalamic
                      lesions. Little is known regarding its frequency and
                      phenotype. We examined the frequency of thalamic aphasia
                      following Isolated Acute unilateral ischemic Lesions in the
                      Thalamus (IALT) with respect to lesion location.
                      Furthermore, we characterized thalamic aphasia according to
                      affected language domains and severity.Fifty-two patients
                      with IALT were analyzed $[44\%$ female, median age:
                      73 years (IQR: 60-79)]. Lesion location was determined
                      using 3-Tesla magnetic resonance imaging and categorized as
                      anterior, posterior, paramedian or inferolateral.
                      Standardized language assessment was performed using the
                      validated Aphasia checklist (ACL) directly after symptom
                      onset. Aphasia was defined as an ACL sum score of < 135
                      (range: 0-148).Of 52 patients, 23 $(44\%)$ fulfilled the ACL
                      diagnostic criteria for aphasia, including nearly all lesion
                      locations and both sides. The average ACL sum score was 132
                      ± 11 (range: 98-147). Aphasia was characterized by deficits
                      within domains of complex understanding of speech and verbal
                      fluency. Patients with left anterior IALT were most severely
                      affected, having significantly lower ACL scores than all
                      other patients (117 ± 13 vs. 135 ± 8; p < 0.001). In
                      particular, aphasia in patients with left anterior IALT was
                      characterized by significantly worse performance in the
                      rating of verbal communication, verbal fluency, and naming
                      (all p ≤ 0.001).Aphasia occurs in almost half of patients
                      with focal thalamic lesions. Thalamic aphasia is not
                      confined to one predefined thalamic lesion location, but
                      language deficits are particularly pronounced in patients
                      with left anterior IALT presenting with a distinct pattern.},
      keywords     = {Aged / Aphasia: etiology / Female / Humans / Language /
                      Magnetic Resonance Imaging / Male / Phenotype / Speech /
                      Stroke / Thalamus: diagnostic imaging / Aphasia (Other) /
                      Language (Other) / Stroke (Other) / Thalamus (Other)},
      cin          = {AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8739316},
      pubmed       = {pmid:34100990},
      doi          = {10.1007/s00415-021-10640-4},
      url          = {https://pub.dzne.de/record/155161},
}