Home > Publications Database > Frequency and phenotype of thalamic aphasia. > print

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005     20240320115508.0
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037 _ _ |a DZNE-2021-00482
041 _ _ |a English
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100 1 _ |a Rangus, Ida
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245 _ _ |a Frequency and phenotype of thalamic aphasia.
260 _ _ |a Berlin
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520 _ _ |a Aphasia is a recognized presenting symptom of thalamic lesions. Little is known regarding its frequency and phenotype. We examined the frequency of thalamic aphasia following Isolated Acute unilateral ischemic Lesions in the Thalamus (IALT) with respect to lesion location. Furthermore, we characterized thalamic aphasia according to affected language domains and severity.Fifty-two patients with IALT were analyzed [44% female, median age: 73 years (IQR: 60-79)]. Lesion location was determined using 3-Tesla magnetic resonance imaging and categorized as anterior, posterior, paramedian or inferolateral. Standardized language assessment was performed using the validated Aphasia checklist (ACL) directly after symptom onset. Aphasia was defined as an ACL sum score of < 135 (range: 0-148).Of 52 patients, 23 (44%) fulfilled the ACL diagnostic criteria for aphasia, including nearly all lesion locations and both sides. The average ACL sum score was 132 ± 11 (range: 98-147). Aphasia was characterized by deficits within domains of complex understanding of speech and verbal fluency. Patients with left anterior IALT were most severely affected, having significantly lower ACL scores than all other patients (117 ± 13 vs. 135 ± 8; p < 0.001). In particular, aphasia in patients with left anterior IALT was characterized by significantly worse performance in the rating of verbal communication, verbal fluency, and naming (all p ≤ 0.001).Aphasia occurs in almost half of patients with focal thalamic lesions. Thalamic aphasia is not confined to one predefined thalamic lesion location, but language deficits are particularly pronounced in patients with left anterior IALT presenting with a distinct pattern.
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542 _ _ |i 2021-06-08
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542 _ _ |i 2021-06-08
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650 _ 7 |a Aphasia
|2 Other
650 _ 7 |a Language
|2 Other
650 _ 7 |a Stroke
|2 Other
650 _ 7 |a Thalamus
|2 Other
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aphasia: etiology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Language
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Phenotype
|2 MeSH
650 _ 2 |a Speech
|2 MeSH
650 _ 2 |a Stroke
|2 MeSH
650 _ 2 |a Thalamus: diagnostic imaging
|2 MeSH
700 1 _ |a Fritsch, Merve
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700 1 _ |a Endres, Matthias
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700 1 _ |a Udke, Birgit
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700 1 _ |a Nolte, Christian
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773 1 8 |a 10.1007/s00415-021-10640-4
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|t Journal of Neurology
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999 C 5 |a 10.1016/0093-934x(85)90085-9
|9 -- missing cx lookup --
|1 B Crosson
|p 257 -
|2 Crossref
|u Crosson B (1985) Subcortical functions in language: a working model. Brain Lang 25:257–292. https://doi.org/10.1016/0093-934x(85)90085-9
|t Brain Lang
|v 25
|y 1985
999 C 5 |a 10.1001/archneur.1988.00520350067018
|9 -- missing cx lookup --
|1 EJ Metter
|p 1229 -
|2 Crossref
|u Metter EJ, Riege WH, Hanson WR, Jackson CA, Kempler D, van Lancker D (1988) Subcortical structures in Aphasia. Arch Neurol 45:1229–1234. https://doi.org/10.1001/archneur.1988.00520350067018
|t Arch Neurol
|v 45
|y 1988
999 C 5 |a 10.1161/01.STR.0000087786.38997.9E
|9 -- missing cx lookup --
|1 JD Schmahmann
|p 2264 -
|2 Crossref
|u Schmahmann JD (2003) Vascular syndromes of the thalamus. Stroke 34(9):2264–2278. https://doi.org/10.1161/01.STR.0000087786.38997.9E
|t Stroke
|v 34
|y 2003
999 C 5 |a 10.1016/j.cortex.2010.09.002
|9 -- missing cx lookup --
|1 L De Witte
|p 273 -
|2 Crossref
|u De Witte L, Brouns R, Kavadias D, Engelborghs S, De Deyn PP, Marien P (2011) Cognitive, affective and behavioural disturbances following vascular thalamic lesions: a review. Cortex 47(3):273–319. https://doi.org/10.1016/j.cortex.2010.09.002
|t Cortex
|v 47
|y 2011
999 C 5 |a 10.1007/s10072-016-2476-2
|9 -- missing cx lookup --
|1 A Osawa
|p 565 -
|2 Crossref
|u Osawa A, Maeshima S (2016) Aphasia and unilateral spatial neglect due to acute thalamic hemorrhage: clinical correlations and outcomes. Neurol Sci 37(4):565–572. https://doi.org/10.1007/s10072-016-2476-2
|t Neurol Sci
|v 37
|y 2016
999 C 5 |a 10.1007/BF00878870
|9 -- missing cx lookup --
|1 N Sodeyama
|p 289 -
|2 Crossref
|u Sodeyama N, Tamaki M, Sugishita M (1995) Persistent pure verbal amnesia and transient aphasia after left thalamic infarction. J Neurol 242(5):289–294. https://doi.org/10.1007/BF00878870
|t J Neurol
|v 242
|y 1995
999 C 5 |a 10.1007/s00415-019-09560-1
|9 -- missing cx lookup --
|1 M Fritsch
|p 106 -
|2 Crossref
|u Fritsch M, Krause T, Klostermann F, Villringer K, Ihrke M, Nolte CH (2020) “Thalamic aphasia” after stroke is associated with left anterior lesion location. J Neurol 267(1):106–112. https://doi.org/10.1007/s00415-019-09560-1
|t J Neurol
|v 267
|y 2020
999 C 5 |a 10.1016/s0022-510x(99)00267-1
|9 -- missing cx lookup --
|1 D Karussis
|p 25 -
|2 Crossref
|u Karussis D, Leker RR, Abramsky O (2000) Cognitive dysfunction following thalamic stroke: a study of 16 cases and review of the literature. J Neurol Sci 172:25–29. https://doi.org/10.1016/s0022-510x(99)00267-1
|t J Neurol Sci
|v 172
|y 2000
999 C 5 |a 10.3389/fneur.2014.00231
|9 -- missing cx lookup --
|1 R Sebastian
|p 231 -
|2 Crossref
|u Sebastian R, Schein MG, Davis C, Gomez Y, Newhart M, Oishi K, Hillis AE (2014) Aphasia or neglect after thalamic stroke: the various ways they may be related to cortical hypoperfusion. Front Neurol 5:231. https://doi.org/10.3389/fneur.2014.00231
|t Front Neurol
|v 5
|y 2014
999 C 5 |a 10.1161/01.STR.26.4.620
|9 -- missing cx lookup --
|1 S Mori
|p 620 -
|2 Crossref
|u Mori S, Sadoshima S, Ibayashi S, Fujishima M, Iino K (1995) Impact of thalamic hematoma on six-month mortality and motor and cognitive functional outcome. Stroke 26(4):620–626. https://doi.org/10.1161/01.STR.26.4.620
|t Stroke
|v 26
|y 1995
999 C 5 |a 10.1080/02687030244000176
|9 -- missing cx lookup --
|1 M Purdy
|p 549 -
|2 Crossref
|u Purdy M (2002) Executive function ability in persons with aphasia. Aphasiology 16(4–6):549–557. https://doi.org/10.1080/02687030244000176
|t Aphasiology
|v 16
|y 2002
999 C 5 |a 10.1046/j.1468-1331.2003.00604.x
|9 -- missing cx lookup --
|1 DC Kuljic-Obradovic
|p 445 -
|2 Crossref
|u Kuljic-Obradovic DC (2003) Subcortical aphasia: three different language disorder syndromes? Eur J Neurol 10(4):445–448. https://doi.org/10.1046/j.1468-1331.2003.00604.x
|t Eur J Neurol
|v 10
|y 2003
999 C 5 |a 10.1016/s0093-934x(02)00554-0
|9 -- missing cx lookup --
|1 M Radanovic
|p 337 -
|2 Crossref
|u Radanovic M, Scaff M (2003) Speech and language disturbances due to subcortical lesions. Brain Lang 84(3):337–352. https://doi.org/10.1016/s0093-934x(02)00554-0
|t Brain Lang
|v 84
|y 2003
999 C 5 |a 10.1006/brln.1997.1707
|9 -- missing cx lookup --
|1 SE Nadeau
|p 355 -
|2 Crossref
|u Nadeau SE, Crosson B (1997) Subcortical Aphasia. Brain Lang 58:355–402. https://doi.org/10.1006/brln.1997.1707
|t Brain Lang
|v 58
|y 1997
999 C 5 |a 10.1016/j.bandl.2012.06.011
|9 -- missing cx lookup --
|1 B Crosson
|p 73 -
|2 Crossref
|u Crosson B (2013) Thalamic mechanisms in language: a reconsideration based on recent findings and concepts. Brain Lang 126(1):73–88. https://doi.org/10.1016/j.bandl.2012.06.011
|t Brain Lang
|v 126
|y 2013
999 C 5 |a 10.1212/wnl.38.6.837
|9 -- missing cx lookup --
|1 J Bogousslavsky
|p 837 -
|2 Crossref
|u Bogousslavsky J, Regli F, Uske A (1988) Thalamic infarcts: clinical syndromes, etiology and prognosis. Neurology 38:837–848. https://doi.org/10.1212/wnl.38.6.837
|t Neurology
|v 38
|y 1988
999 C 5 |a 10.1161/01.STR.0000147039.49252.2f
|9 -- missing cx lookup --
|1 E Carrera
|p 2826 -
|2 Crossref
|u Carrera E, Michel P, Bogousslavsky J (2004) Anteromedian, central, and posterolateral infarcts of the thalamus: three variant types. Stroke 35(12):2826–2831. https://doi.org/10.1161/01.STR.0000147039.49252.2f
|t Stroke
|v 35
|y 2004
999 C 5 |a 10.1007/bf00315956
|9 -- missing cx lookup --
|1 G Percheron
|p 1 -
|2 Crossref
|u Percheron G (1973) The anatomy of the arterial supply of the human thalamus and its use for the interpretation of the thalamic vascular pathology. Z Neurol 205(1):1–13. https://doi.org/10.1007/bf00315956
|t Z Neurol
|v 205
|y 1973
999 C 5 |a 10.1080/13803390490918273
|9 -- missing cx lookup --
|1 E Kalbe
|p 779 -
|2 Crossref
|u Kalbe E, Reinhold N, Brand M, Markowitsch HJ, Kessler J (2005) A new test battery to assess aphasic disturbances and associated cognitive dysfunctions—German normative data on the aphasia check list. J Clin Exp Neuropsychol 27(7):779–794. https://doi.org/10.1080/13803390490918273
|t J Clin Exp Neuropsychol
|v 27
|y 2005
999 C 5 |1 JA Cohen
|y 1980
|2 Crossref
|u Cohen JA, Gelfer CE, Sweet RD (1980) Thalamic infarction producing aphasia. Mt Sinai J Med 47(4):398–404
999 C 5 |a 10.1080/02687030244000446
|9 -- missing cx lookup --
|1 B-M Whelan
|p 1213 -
|2 Crossref
|u Whelan B-M, Murdoch BE, Theodoros DG, Silburn P, Hall B (2002) A role for the dominant thalamus in language? A linguistic comparison of two cases subsequent to unilateral thalamotomy procedures in the dominant and non-dominant hemispheres. Aphasiology 16(12):1213–1226. https://doi.org/10.1080/02687030244000446
|t Aphasiology
|v 16
|y 2002
999 C 5 |a 10.1080/02687030500174050
|9 -- missing cx lookup --
|1 B-M Whelan
|p 1097 -
|2 Crossref
|u Whelan B-M, Murdoch B (2005) Unravelling subcortical linguistic substrates: comparison of thalamic versus cerebellar cognitive-linguistic regulation mechanisms. Aphasiology 19(12):1097–1106. https://doi.org/10.1080/02687030500174050
|t Aphasiology
|v 19
|y 2005
999 C 5 |a 10.3389/fpsyg.2014.00772
|9 -- missing cx lookup --
|1 Z Shao
|p 772 -
|2 Crossref
|u Shao Z, Janse E, Visser K, Meyer AS (2014) What do verbal fluency tasks measure? Predictors of verbal fluency performance in older adults. Front Psychol 5:772. https://doi.org/10.3389/fpsyg.2014.00772
|t Front Psychol
|v 5
|y 2014
999 C 5 |a 10.1080/23279095.2015.1004574
|9 -- missing cx lookup --
|1 DM Whiteside
|p 29 -
|2 Crossref
|u Whiteside DM, Kealey T, Semla M, Luu H, Rice L, Basso MR, Roper B (2016) Verbal fluency: language or executive function measure? Appl Neuropsychol Adult 23(1):29–34. https://doi.org/10.1080/23279095.2015.1004574
|t Appl Neuropsychol Adult
|v 23
|y 2016
999 C 5 |a 10.1016/j.bandl.2012.06.004
|9 -- missing cx lookup --
|1 DA Llano
|p 62 -
|2 Crossref
|u Llano DA (2013) Functional imaging of the thalamus in language. Brain Lang 126(1):62–72. https://doi.org/10.1016/j.bandl.2012.06.004
|t Brain Lang
|v 126
|y 2013
999 C 5 |a 10.1016/j.cognition.2002.06.001
|9 -- missing cx lookup --
|1 P Indefrey
|p 101 -
|2 Crossref
|u Indefrey P, Levelt WJ (2004) The spatial and temporal signatures of word production components. Cognition 92(1–2):101–144. https://doi.org/10.1016/j.cognition.2002.06.001
|t Cognition
|v 92
|y 2004
999 C 5 |a 10.3389/fnana.2013.00008
|9 -- missing cx lookup --
|1 AA Ford
|p 8 -
|2 Crossref
|u Ford AA, Triplett W, Sudhyadhom A, Gullett J, McGregor K, Fitzgerald DB, Mareci T, White K, Crosson B (2013) Broca’s area and its striatal and thalamic connections: a diffusion—MRI tractography study. Front Neuroanat 7:8. https://doi.org/10.3389/fnana.2013.00008
|t Front Neuroanat
|v 7
|y 2013
999 C 5 |a 10.1002/cne.902950212
|9 -- missing cx lookup --
|1 JD Schmahmann
|p 299 -
|2 Crossref
|u Schmahmann JD, Pandya DN (1990) Anatomical investigation of projections from thalamus to posterior parietal cortex in the rhesus monkey: a WGA-HRP and fluorescent tracer study. J Comp Neurol 295(2):299–326. https://doi.org/10.1002/cne.902950212
|t J Comp Neurol
|v 295
|y 1990
999 C 5 |a 10.1007/bf00236173
|9 -- missing cx lookup --
|1 J Kievit
|p 299 -
|2 Crossref
|u Kievit J, Kuypers HG (1977) Organization of the thalamo-cortical connexions to the frontal lobe in the rhesus monkey. Exp Brain Res 29(3–4):299–322. https://doi.org/10.1007/bf00236173
|t Exp Brain Res
|v 29
|y 1977
999 C 5 |a 10.1002/cne.902820107
|9 -- missing cx lookup --
|1 EH Yeterian
|p 80 -
|2 Crossref
|u Yeterian EH, Pandya DN (1989) Thalamic connections of the cortex of the superior temporal sulcus in the rhesus monkey. J Comp Neurol 282(1):80–97. https://doi.org/10.1002/cne.902820107
|t J Comp Neurol
|v 282
|y 1989

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