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000155541 0247_ $$2ISSN$$a2051-2023
000155541 037__ $$aDZNE-2021-00719
000155541 041__ $$aEnglish
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000155541 1001_ $$0P:(DE-2719)2812615$$aCoors, Annabell$$b0$$eFirst author
000155541 245__ $$aPolygenic risk scores for schizophrenia are associated with oculomotor endophenotypes.
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000155541 520__ $$aSchizophrenia is a heterogeneous disorder with substantial heritability. The use of endophenotypes may help clarify its aetiology. Measures from the smooth pursuit and antisaccade eye movement tasks have been identified as endophenotypes for schizophrenia in twin and family studies. However, the genetic basis of the overlap between schizophrenia and these oculomotor markers is largely unknown. Here, we tested whether schizophrenia polygenic risk scores (PRS) were associated with oculomotor performance in the general population.Analyses were based on the data of 2956 participants (aged 30-95) of the Rhineland Study, a community-based cohort study in Bonn, Germany. Genotyping was performed on Omni-2.5 exome arrays. Using summary statistics from a recent meta-analysis based on the two largest schizophrenia genome-wide association studies to date, we quantified genetic risk for schizophrenia by creating PRS at different p value thresholds for genetic markers. We examined associations between PRS and oculomotor performance using multivariable regression models.Higher PRS were associated with higher antisaccade error rate and latency, and lower antisaccade amplitude gain. PRS showed inconsistent patterns of association with smooth pursuit velocity gain and were not associated with saccade rate during smooth pursuit or performance on a prosaccade control task.There is an overlap between genetic determinants of schizophrenia and oculomotor endophenotypes. Our findings suggest that the mechanisms that underlie schizophrenia also affect oculomotor function in the general population.
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000155541 650_7 $$2Other$$aAntisaccade
000155541 650_7 $$2Other$$aepidemiology
000155541 650_7 $$2Other$$aeye movement
000155541 650_7 $$2Other$$agenetic risk score
000155541 650_7 $$2Other$$agenetics
000155541 650_7 $$2Other$$aprosaccade
000155541 650_7 $$2Other$$asmooth pursuit
000155541 650_2 $$2MeSH$$aHumans
000155541 650_2 $$2MeSH$$aEye Movements
000155541 650_2 $$2MeSH$$aSchizophrenia: genetics
000155541 650_2 $$2MeSH$$aEndophenotypes
000155541 650_2 $$2MeSH$$aGenome-Wide Association Study
000155541 650_2 $$2MeSH$$aCohort Studies
000155541 650_2 $$2MeSH$$aRisk Factors
000155541 693__ $$0EXP:(DE-2719)Rhineland Study-20190321$$5EXP:(DE-2719)Rhineland Study-20190321$$eRhineland Study / Bonn$$x0
000155541 7001_ $$0P:(DE-2719)9002347$$aImtiaz, Mohammed-Aslam$$b1$$udzne
000155541 7001_ $$0P:(DE-2719)2811413$$aBönniger, Meta-Miriam$$b2
000155541 7001_ $$0P:(DE-2719)2812578$$aAziz, N. Ahmad$$b3
000155541 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique M B$$b4
000155541 7001_ $$00000-0002-0160-0281$$aEttinger, Ulrich$$b5
000155541 773__ $$0PERI:(DE-600)1470300-2$$a10.1017/S0033291721003251$$gp. 1 - 9$$n4$$p1611-1619$$tPsychological medicine$$v53$$x1469-8978$$y2023
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000155541 9141_ $$y2021
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