Journal Article

DZNE-2021-00719

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Polygenic risk scores for schizophrenia are associated with oculomotor endophenotypes.

Coors, A. (First author)DZNE* ; Imtiaz, M.-A.DZNE* ; Bönniger, M.-M.DZNE* ; Aziz, N. A.DZNE* ; Breteler, M. M. B.DZNE* ; Ettinger, U.

2023
Proquest [S.l.]

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Please use a persistent id in citations: doi:10.1017/S0033291721003251

Abstract: Schizophrenia is a heterogeneous disorder with substantial heritability. The use of endophenotypes may help clarify its aetiology. Measures from the smooth pursuit and antisaccade eye movement tasks have been identified as endophenotypes for schizophrenia in twin and family studies. However, the genetic basis of the overlap between schizophrenia and these oculomotor markers is largely unknown. Here, we tested whether schizophrenia polygenic risk scores (PRS) were associated with oculomotor performance in the general population.Analyses were based on the data of 2956 participants (aged 30-95) of the Rhineland Study, a community-based cohort study in Bonn, Germany. Genotyping was performed on Omni-2.5 exome arrays. Using summary statistics from a recent meta-analysis based on the two largest schizophrenia genome-wide association studies to date, we quantified genetic risk for schizophrenia by creating PRS at different p value thresholds for genetic markers. We examined associations between PRS and oculomotor performance using multivariable regression models.Higher PRS were associated with higher antisaccade error rate and latency, and lower antisaccade amplitude gain. PRS showed inconsistent patterns of association with smooth pursuit velocity gain and were not associated with saccade rate during smooth pursuit or performance on a prosaccade control task.There is an overlap between genetic determinants of schizophrenia and oculomotor endophenotypes. Our findings suggest that the mechanisms that underlie schizophrenia also affect oculomotor function in the general population.

Keyword(s): Humans (MeSH) ; Eye Movements (MeSH) ; Schizophrenia: genetics (MeSH) ; Endophenotypes (MeSH) ; Genome-Wide Association Study (MeSH) ; Cohort Studies (MeSH) ; Risk Factors (MeSH) ; Antisaccade ; epidemiology ; eye movement ; genetic risk score ; genetics ; prosaccade ; smooth pursuit

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Contributing Institute(s):

1. Population & Clinical Neuroepidemiology (AG Aziz)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Experiment(s):

1. Rhineland Study / Bonn

Appears in the scientific report 2021

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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