TY  - JOUR
AU  - Coors, Annabell
AU  - Imtiaz, Mohammed-Aslam
AU  - Bönniger, Meta-Miriam
AU  - Aziz, N. Ahmad
AU  - Breteler, Monique M B
AU  - Ettinger, Ulrich
TI  - Polygenic risk scores for schizophrenia are associated with oculomotor endophenotypes.
JO  - Psychological medicine
VL  - 53
IS  - 4
SN  - 1469-8978
CY  - [S.l.]
PB  - Proquest
M1  - DZNE-2021-00719
SP  - 1611-1619
PY  - 2023
AB  - Schizophrenia is a heterogeneous disorder with substantial heritability. The use of endophenotypes may help clarify its aetiology. Measures from the smooth pursuit and antisaccade eye movement tasks have been identified as endophenotypes for schizophrenia in twin and family studies. However, the genetic basis of the overlap between schizophrenia and these oculomotor markers is largely unknown. Here, we tested whether schizophrenia polygenic risk scores (PRS) were associated with oculomotor performance in the general population.Analyses were based on the data of 2956 participants (aged 30-95) of the Rhineland Study, a community-based cohort study in Bonn, Germany. Genotyping was performed on Omni-2.5 exome arrays. Using summary statistics from a recent meta-analysis based on the two largest schizophrenia genome-wide association studies to date, we quantified genetic risk for schizophrenia by creating PRS at different p value thresholds for genetic markers. We examined associations between PRS and oculomotor performance using multivariable regression models.Higher PRS were associated with higher antisaccade error rate and latency, and lower antisaccade amplitude gain. PRS showed inconsistent patterns of association with smooth pursuit velocity gain and were not associated with saccade rate during smooth pursuit or performance on a prosaccade control task.There is an overlap between genetic determinants of schizophrenia and oculomotor endophenotypes. Our findings suggest that the mechanisms that underlie schizophrenia also affect oculomotor function in the general population.
KW  - Humans
KW  - Eye Movements
KW  - Schizophrenia: genetics
KW  - Endophenotypes
KW  - Genome-Wide Association Study
KW  - Cohort Studies
KW  - Risk Factors
KW  - Antisaccade (Other)
KW  - epidemiology (Other)
KW  - eye movement (Other)
KW  - genetic risk score (Other)
KW  - genetics (Other)
KW  - prosaccade (Other)
KW  - smooth pursuit (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10009390
C6  - pmid:34412712
DO  - DOI:10.1017/S0033291721003251
UR  - https://pub.dzne.de/record/155541
ER  -