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@ARTICLE{Coors:155541,
      author       = {Coors, Annabell and Imtiaz, Mohammed-Aslam and Bönniger,
                      Meta-Miriam and Aziz, N. Ahmad and Breteler, Monique M B and
                      Ettinger, Ulrich},
      title        = {{P}olygenic risk scores for schizophrenia are associated
                      with oculomotor endophenotypes.},
      journal      = {Psychological medicine},
      volume       = {53},
      number       = {4},
      issn         = {1469-8978},
      address      = {[S.l.]},
      publisher    = {Proquest},
      reportid     = {DZNE-2021-00719},
      pages        = {1611-1619},
      year         = {2023},
      abstract     = {Schizophrenia is a heterogeneous disorder with substantial
                      heritability. The use of endophenotypes may help clarify its
                      aetiology. Measures from the smooth pursuit and antisaccade
                      eye movement tasks have been identified as endophenotypes
                      for schizophrenia in twin and family studies. However, the
                      genetic basis of the overlap between schizophrenia and these
                      oculomotor markers is largely unknown. Here, we tested
                      whether schizophrenia polygenic risk scores (PRS) were
                      associated with oculomotor performance in the general
                      population.Analyses were based on the data of 2956
                      participants (aged 30-95) of the Rhineland Study, a
                      community-based cohort study in Bonn, Germany. Genotyping
                      was performed on Omni-2.5 exome arrays. Using summary
                      statistics from a recent meta-analysis based on the two
                      largest schizophrenia genome-wide association studies to
                      date, we quantified genetic risk for schizophrenia by
                      creating PRS at different p value thresholds for genetic
                      markers. We examined associations between PRS and oculomotor
                      performance using multivariable regression models.Higher PRS
                      were associated with higher antisaccade error rate and
                      latency, and lower antisaccade amplitude gain. PRS showed
                      inconsistent patterns of association with smooth pursuit
                      velocity gain and were not associated with saccade rate
                      during smooth pursuit or performance on a prosaccade control
                      task.There is an overlap between genetic determinants of
                      schizophrenia and oculomotor endophenotypes. Our findings
                      suggest that the mechanisms that underlie schizophrenia also
                      affect oculomotor function in the general population.},
      keywords     = {Humans / Eye Movements / Schizophrenia: genetics /
                      Endophenotypes / Genome-Wide Association Study / Cohort
                      Studies / Risk Factors / Antisaccade (Other) / epidemiology
                      (Other) / eye movement (Other) / genetic risk score (Other)
                      / genetics (Other) / prosaccade (Other) / smooth pursuit
                      (Other)},
      cin          = {AG Aziz},
      ddc          = {610},
      cid          = {I:(DE-2719)5000071},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      experiment   = {EXP:(DE-2719)Rhineland Study-20190321},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10009390},
      pubmed       = {pmid:34412712},
      doi          = {10.1017/S0033291721003251},
      url          = {https://pub.dzne.de/record/155541},
}