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@ARTICLE{Becker:155542,
      author       = {Becker, Sara and Pauly, Claire and Lawton, Michael and
                      Hipp, Geraldine and Bowring, Francesca and Sulzer, Patricia
                      and Hu, Michele and Krüger, Rejko and Gasser, Thomas and
                      Liepelt-Scarfone, Inga},
      title        = {{Q}uantifying activities of daily living impairment in
                      {P}arkinson's disease using the {F}unctional {A}ctivities
                      {Q}uestionnaire.},
      journal      = {Neurological sciences},
      volume       = {43},
      number       = {2},
      issn         = {1590-3478},
      address      = {Milano},
      publisher    = {Springer},
      reportid     = {DZNE-2021-00720},
      pages        = {1047-1054},
      year         = {2022},
      abstract     = {Cognitive-driven activity of daily living (ADL) impairment
                      in Parkinson's disease (PD) is increasingly discussed as
                      prodromal marker for dementia. Diagnostic properties of
                      assessments for this specific ADL impairment are sparsely
                      investigated in PD. The ability of the Functional Activities
                      Questionnaire (FAQ) for differentiating between PD patients
                      with normal cognition and with mild cognitive impairment
                      (PD-MCI), according to informant and self-reports, was
                      examined. Global cognitive function in groups with and
                      without mild ADL impairment was compared according to
                      different cut-offs.Multicenter data of 589 patients of an
                      international cohort (CENTRE-PD) were analyzed. Analyses
                      were run separately for informant-rated and self-rated FAQ.
                      Receiver operating characteristic (ROC) analysis was
                      conducted to define the optimal FAQ cut-off for PD-MCI (≥
                      1), and groups were additionally split according to reported
                      FAQ cut-offs for PD-MCI in the literature (≥ 3, ≥ 5).
                      Binary logistic regressions examined the effect of the
                      Montreal Cognitive Assessment (MoCA) score in PD patients
                      with and without mild ADL impairment.Two hundred and
                      twenty-five $(38.2\%)$ patients were classified as PD-MCI.
                      For all three cut-off values, sensitivity was moderate to
                      low (< 0.55), but specificity was moderately high (> 0.54)
                      with a tendency of higher values for self-reported deficits.
                      For the self-report, the cut-off ≥ 3 showed a significant
                      effect of the MoCA (B = - 0.31, p = 0.003), where FAQ ≥ 3
                      patients had worse cognition. No effect for group
                      differences based on informant ratings was detected.Our data
                      argue that self-reported ADL impairments assessed by the FAQ
                      show a relation to the severity of cognitive impairment in
                      PD.},
      keywords     = {Activities of Daily Living / Cognitive Dysfunction:
                      diagnosis / Cognitive Dysfunction: etiology / Humans /
                      Mental Status and Dementia Tests / Neuropsychological Tests
                      / Parkinson Disease: complications / Parkinson Disease:
                      diagnosis / Surveys and Questionnaires / Cognitive
                      dysfunction (Other) / Cohort studies (Other) / Mild
                      cognitive impairment (Other) / Neuropsychological tests
                      (Other)},
      cin          = {AG Latz ; AG Latz / AG Gasser / Core ICRU / AG Heutink},
      ddc          = {610},
      cid          = {I:(DE-2719)1013024 / I:(DE-2719)1210000 /
                      I:(DE-2719)1240005 / I:(DE-2719)1210002},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 354 -
                      Disease Prevention and Healthy Aging (POF4-354) / 351 -
                      Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-354 /
                      G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8789696},
      pubmed       = {pmid:34109514},
      doi          = {10.1007/s10072-021-05365-1},
      url          = {https://pub.dzne.de/record/155542},
}