Journal Article

DZNE-2021-00720

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Quantifying activities of daily living impairment in Parkinson's disease using the Functional Activities Questionnaire.

Becker, S. (First author)DZNE* ; Pauly, C. ; Lawton, M. ; Hipp, G. ; Bowring, F. ; Sulzer, P.DZNE* ; Hu, M. ; Krüger, R.Extern* ; Gasser, T.DZNE* ; Liepelt-Scarfone, I. (Last author)DZNE*

2022
Springer Milano

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Please use a persistent id in citations: doi:10.1007/s10072-021-05365-1

Abstract: Cognitive-driven activity of daily living (ADL) impairment in Parkinson's disease (PD) is increasingly discussed as prodromal marker for dementia. Diagnostic properties of assessments for this specific ADL impairment are sparsely investigated in PD. The ability of the Functional Activities Questionnaire (FAQ) for differentiating between PD patients with normal cognition and with mild cognitive impairment (PD-MCI), according to informant and self-reports, was examined. Global cognitive function in groups with and without mild ADL impairment was compared according to different cut-offs.Multicenter data of 589 patients of an international cohort (CENTRE-PD) were analyzed. Analyses were run separately for informant-rated and self-rated FAQ. Receiver operating characteristic (ROC) analysis was conducted to define the optimal FAQ cut-off for PD-MCI (≥ 1), and groups were additionally split according to reported FAQ cut-offs for PD-MCI in the literature (≥ 3, ≥ 5). Binary logistic regressions examined the effect of the Montreal Cognitive Assessment (MoCA) score in PD patients with and without mild ADL impairment.Two hundred and twenty-five (38.2%) patients were classified as PD-MCI. For all three cut-off values, sensitivity was moderate to low (< 0.55), but specificity was moderately high (> 0.54) with a tendency of higher values for self-reported deficits. For the self-report, the cut-off ≥ 3 showed a significant effect of the MoCA (B = - 0.31, p = 0.003), where FAQ ≥ 3 patients had worse cognition. No effect for group differences based on informant ratings was detected.Our data argue that self-reported ADL impairments assessed by the FAQ show a relation to the severity of cognitive impairment in PD.

Keyword(s): Activities of Daily Living (MeSH) ; Cognitive Dysfunction: diagnosis (MeSH) ; Cognitive Dysfunction: etiology (MeSH) ; Humans (MeSH) ; Mental Status and Dementia Tests (MeSH) ; Neuropsychological Tests (MeSH) ; Parkinson Disease: complications (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Surveys and Questionnaires (MeSH) ; Cognitive dysfunction ; Cohort studies ; Mild cognitive impairment ; Neuropsychological tests

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Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz ; AG Latz)
2. Parkinson Genetics (AG Gasser)
3. Core ICRU (Core ICRU)
4. Genome Biology of Neurodegenerative Diseases (AG Heutink)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)
3. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2022

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; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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