%0 Journal Article
%A Schwahn, Christian
%A Frenzel, Stefan
%A Holtfreter, Birte
%A Van der Auwera, Sandra
%A Pink, Christiane
%A Bülow, Robin
%A Friedrich, Nele
%A Völzke, Henry
%A Biffar, Reiner
%A Kocher, Thomas
%A Grabe, Hans Jörgen
%T Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach.
%J Alzheimer's and dementia
%V 18
%N 1
%@ 1552-5279
%C Hoboken, NJ
%I Wiley
%M DZNE-2021-00735
%P 127-141
%D 2022
%X We investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD).In this quasi-experimental design, 177 periodontally treated patients from the 'Greifswald Approach to Individualized Medicine' cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes.Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95
%K Adult
%K Aging: pathology
%K Alzheimer Disease: pathology
%K Atrophy: pathology
%K Brain: pathology
%K Cohort Studies
%K Female
%K Germany: epidemiology
%K Humans
%K Longitudinal Studies
%K Magnetic Resonance Imaging
%K Male
%K Middle Aged
%K Periodontal Diseases: epidemiology
%K Prodromal Symptoms
%K Risk Factors
%K Alzheimer's disease (Other)
%K aging (Other)
%K epidemiology (Other)
%K magnetic resonance imaging (Other)
%K periodontal diseases (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34050719
%R 10.1002/alz.12378
%U https://pub.dzne.de/record/155557