Journal Article

DZNE-2021-00735

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach.

Schwahn, C. (Corresponding author) ; Frenzel, S. ; Holtfreter, B. ; Van der Auwera, S.DZNE* ; Pink, C. ; Bülow, R. ; Friedrich, N. ; Völzke, H. ; Biffar, R. ; Kocher, T. ; Grabe, H. J.DZNE* ; Initiative, A. D. N. (Collaboration Author)

2022
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.12378

Abstract: We investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD).In this quasi-experimental design, 177 periodontally treated patients from the 'Greifswald Approach to Individualized Medicine' cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes.Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95% confidence interval: -0.70 to -0.12; P = .0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain.Periodontitis is related to pre-clinical AD in our population.

Keyword(s): Adult (MeSH) ; Aging: pathology (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Atrophy: pathology (MeSH) ; Brain: pathology (MeSH) ; Cohort Studies (MeSH) ; Female (MeSH) ; Germany: epidemiology (MeSH) ; Humans (MeSH) ; Longitudinal Studies (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Periodontal Diseases: epidemiology (MeSH) ; Prodromal Symptoms (MeSH) ; Risk Factors (MeSH) ; Alzheimer's disease ; aging ; epidemiology ; magnetic resonance imaging ; periodontal diseases

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Contributing Institute(s):

1. Biomarkers of dementia in the general population (AG Grabe)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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