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000155557 0247_ $$2doi$$a10.1002/alz.12378
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000155557 0247_ $$2ISSN$$a1552-5260
000155557 0247_ $$2ISSN$$a1552-5279
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000155557 037__ $$aDZNE-2021-00735
000155557 041__ $$aEnglish
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000155557 1001_ $$00000-0003-4517-9326$$aSchwahn, Christian$$b0$$eCorresponding author
000155557 245__ $$aEffect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach.
000155557 260__ $$aHoboken, NJ$$bWiley$$c2022
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000155557 520__ $$aWe investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD).In this quasi-experimental design, 177 periodontally treated patients from the 'Greifswald Approach to Individualized Medicine' cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes.Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95% confidence interval: -0.70 to -0.12; P = .0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain.Periodontitis is related to pre-clinical AD in our population.
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000155557 650_7 $$2Other$$aAlzheimer's disease
000155557 650_7 $$2Other$$aaging
000155557 650_7 $$2Other$$aepidemiology
000155557 650_7 $$2Other$$amagnetic resonance imaging
000155557 650_7 $$2Other$$aperiodontal diseases
000155557 650_2 $$2MeSH$$aAdult
000155557 650_2 $$2MeSH$$aAging: pathology
000155557 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000155557 650_2 $$2MeSH$$aAtrophy: pathology
000155557 650_2 $$2MeSH$$aBrain: pathology
000155557 650_2 $$2MeSH$$aCohort Studies
000155557 650_2 $$2MeSH$$aFemale
000155557 650_2 $$2MeSH$$aGermany: epidemiology
000155557 650_2 $$2MeSH$$aHumans
000155557 650_2 $$2MeSH$$aLongitudinal Studies
000155557 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000155557 650_2 $$2MeSH$$aMale
000155557 650_2 $$2MeSH$$aMiddle Aged
000155557 650_2 $$2MeSH$$aPeriodontal Diseases: epidemiology
000155557 650_2 $$2MeSH$$aProdromal Symptoms
000155557 650_2 $$2MeSH$$aRisk Factors
000155557 7001_ $$00000-0001-5087-5970$$aFrenzel, Stefan$$b1
000155557 7001_ $$aHoltfreter, Birte$$b2
000155557 7001_ $$0P:(DE-2719)9001174$$aVan der Auwera, Sandra$$b3$$udzne
000155557 7001_ $$aPink, Christiane$$b4
000155557 7001_ $$aBülow, Robin$$b5
000155557 7001_ $$aFriedrich, Nele$$b6
000155557 7001_ $$aVölzke, Henry$$b7
000155557 7001_ $$aBiffar, Reiner$$b8
000155557 7001_ $$aKocher, Thomas$$b9
000155557 7001_ $$0P:(DE-2719)2811781$$aGrabe, Hans Jörgen$$b10$$udzne
000155557 7001_ $$0P:(DE-HGF)0$$aInitiative, Alzheimer's Disease Neuroimaging$$b11$$eCollaboration Author
000155557 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12378$$gp. alz.12378$$n1$$p127-141$$tAlzheimer's and dementia$$v18$$x1552-5279$$y2022
000155557 8564_ $$uhttps://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12378
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