TY  - JOUR
AU  - Schwahn, Christian
AU  - Frenzel, Stefan
AU  - Holtfreter, Birte
AU  - Van der Auwera, Sandra
AU  - Pink, Christiane
AU  - Bülow, Robin
AU  - Friedrich, Nele
AU  - Völzke, Henry
AU  - Biffar, Reiner
AU  - Kocher, Thomas
AU  - Grabe, Hans Jörgen
TI  - Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach.
JO  - Alzheimer's and dementia
VL  - 18
IS  - 1
SN  - 1552-5279
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2021-00735
SP  - 127-141
PY  - 2022
AB  - We investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD).In this quasi-experimental design, 177 periodontally treated patients from the 'Greifswald Approach to Individualized Medicine' cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes.Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95
KW  - Adult
KW  - Aging: pathology
KW  - Alzheimer Disease: pathology
KW  - Atrophy: pathology
KW  - Brain: pathology
KW  - Cohort Studies
KW  - Female
KW  - Germany: epidemiology
KW  - Humans
KW  - Longitudinal Studies
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Periodontal Diseases: epidemiology
KW  - Prodromal Symptoms
KW  - Risk Factors
KW  - Alzheimer's disease (Other)
KW  - aging (Other)
KW  - epidemiology (Other)
KW  - magnetic resonance imaging (Other)
KW  - periodontal diseases (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34050719
DO  - DOI:10.1002/alz.12378
UR  - https://pub.dzne.de/record/155557
ER  -