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@ARTICLE{Schwahn:155557,
      author       = {Schwahn, Christian and Frenzel, Stefan and Holtfreter,
                      Birte and Van der Auwera, Sandra and Pink, Christiane and
                      Bülow, Robin and Friedrich, Nele and Völzke, Henry and
                      Biffar, Reiner and Kocher, Thomas and Grabe, Hans Jörgen},
      collaboration = {Initiative, Alzheimer's Disease Neuroimaging},
      title        = {{E}ffect of periodontal treatment on preclinical
                      {A}lzheimer's disease-{R}esults of a trial emulation
                      approach.},
      journal      = {Alzheimer's and dementia},
      volume       = {18},
      number       = {1},
      issn         = {1552-5279},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-00735},
      pages        = {127-141},
      year         = {2022},
      abstract     = {We investigated the relationship between periodontal
                      treatment and pre-clinical Alzheimer's disease (AD).In this
                      quasi-experimental design, 177 periodontally treated
                      patients from the 'Greifswald Approach to Individualized
                      Medicine' cohort, which used the same protocols as the
                      population-based Study of Health in Pomerania TREND
                      (SHIP-TREND), and 409 untreated subjects from SHIP-TREND
                      were analyzed. Subjects were younger than 60 years at the
                      magnetic resonance imaging examination, with a median
                      observation period of 7.3 years. Imaging markers for brain
                      atrophy in late-onset AD and brain aging were used as the
                      outcomes.Robust to sensitivity analyses, periodontal
                      treatment had a favorable effect on AD-related brain atrophy
                      (-0.41; $95\%$ confidence interval: -0.70 to -0.12;
                      P = .0051), which corresponds to a shift from the 50th to
                      the 37th percentile of the outcome distribution. For brain
                      aging, the treatment effect was uncertain.Periodontitis is
                      related to pre-clinical AD in our population.},
      keywords     = {Adult / Aging: pathology / Alzheimer Disease: pathology /
                      Atrophy: pathology / Brain: pathology / Cohort Studies /
                      Female / Germany: epidemiology / Humans / Longitudinal
                      Studies / Magnetic Resonance Imaging / Male / Middle Aged /
                      Periodontal Diseases: epidemiology / Prodromal Symptoms /
                      Risk Factors / Alzheimer's disease (Other) / aging (Other) /
                      epidemiology (Other) / magnetic resonance imaging (Other) /
                      periodontal diseases (Other)},
      cin          = {AG Grabe},
      ddc          = {610},
      cid          = {I:(DE-2719)5000001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34050719},
      doi          = {10.1002/alz.12378},
      url          = {https://pub.dzne.de/record/155557},
}