Home > Publications Database > Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach. > print

001     155557
005     20240320115510.0
024 7 _ |a 10.1002/alz.12378
|2 doi
024 7 _ |a pmid:34050719
|2 pmid
024 7 _ |a 1552-5260
|2 ISSN
024 7 _ |a 1552-5279
|2 ISSN
024 7 _ |a altmetric:106700007
|2 altmetric
037 _ _ |a DZNE-2021-00735
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Schwahn, Christian
|0 0000-0003-4517-9326
|b 0
|e Corresponding author
245 _ _ |a Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach.
260 _ _ |a Hoboken, NJ
|c 2022
|b Wiley
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1645174623_18287
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a We investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD).In this quasi-experimental design, 177 periodontally treated patients from the 'Greifswald Approach to Individualized Medicine' cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes.Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95% confidence interval: -0.70 to -0.12; P = .0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain.Periodontitis is related to pre-clinical AD in our population.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a aging
|2 Other
650 _ 7 |a epidemiology
|2 Other
650 _ 7 |a magnetic resonance imaging
|2 Other
650 _ 7 |a periodontal diseases
|2 Other
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aging: pathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Atrophy: pathology
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
650 _ 2 |a Cohort Studies
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Germany: epidemiology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Longitudinal Studies
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Periodontal Diseases: epidemiology
|2 MeSH
650 _ 2 |a Prodromal Symptoms
|2 MeSH
650 _ 2 |a Risk Factors
|2 MeSH
700 1 _ |a Frenzel, Stefan
|0 0000-0001-5087-5970
|b 1
700 1 _ |a Holtfreter, Birte
|b 2
700 1 _ |a Van der Auwera, Sandra
|0 P:(DE-2719)9001174
|b 3
|u dzne
700 1 _ |a Pink, Christiane
|b 4
700 1 _ |a Bülow, Robin
|b 5
700 1 _ |a Friedrich, Nele
|b 6
700 1 _ |a Völzke, Henry
|b 7
700 1 _ |a Biffar, Reiner
|b 8
700 1 _ |a Kocher, Thomas
|b 9
700 1 _ |a Grabe, Hans Jörgen
|0 P:(DE-2719)2811781
|b 10
|u dzne
700 1 _ |a Initiative, Alzheimer's Disease Neuroimaging
|0 P:(DE-HGF)0
|b 11
|e Collaboration Author
773 _ _ |a 10.1002/alz.12378
|g p. alz.12378
|0 PERI:(DE-600)2201940-6
|n 1
|p 127-141
|t Alzheimer's and dementia
|v 18
|y 2022
|x 1552-5279
856 4 _ |u https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12378
856 4 _ |u https://pub.dzne.de/record/155557/files/19574.pdf
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/155557/files/19574.pdf?subformat=pdfa
|x pdfa
|y OpenAccess
909 C O |o oai:pub.dzne.de:155557
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 3
|6 P:(DE-2719)9001174
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 10
|6 P:(DE-2719)2811781
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-353
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
913 0 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-344
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2022
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2022-11-11
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2022-11-11
915 _ _ |a Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
|0 LIC:(DE-HGF)CCBYNCND4
|2 HGFVOC
915 _ _ |a IF >= 15
|0 StatID:(DE-HGF)9915
|2 StatID
|b ALZHEIMERS DEMENT : 2021
|d 2022-11-11
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b ALZHEIMERS DEMENT : 2021
|d 2022-11-11
915 _ _ |a DEAL Wiley
|0 StatID:(DE-HGF)3001
|2 StatID
|d 2021-01-28
|w ger
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-01-28
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2022-11-11
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-01-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1110
|2 StatID
|b Current Contents - Clinical Medicine
|d 2022-11-11
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2022-11-11
920 1 _ |0 I:(DE-2719)5000001
|k AG Grabe
|l Biomarkers of dementia in the general population
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)5000001
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21