Journal Article (Review Article)

DZNE-2021-00762

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel.

Babiloni, C. (Corresponding author) ; Arakaki, X. ; Azami, H. ; Bennys, K. ; Blinowska, K. ; Bonanni, L. ; Bujan, A. ; Carrillo, M. C. ; Cichocki, A. ; de Frutos-Lucas, J. ; Del Percio, C. ; Dubois, B. ; Edelmayer, R. ; Egan, G. ; Epelbaum, S. ; Escudero, J. ; Evans, A. ; Farina, F. ; Fargo, K. ; Fernández, A. ; Ferri, R. ; Frisoni, G. ; Hampel, H. ; Harrington, M. G. ; Jelic, V. ; Jeong, J. ; Jiang, Y. ; Kaminski, M. ; Kavcic, V. ; Kilborn, K. ; Kumar, S. ; Lam, A. ; Lim, L. ; Lizio, R. ; Lopez, D. ; Lopez, S. ; Lucey, B. ; Maestú, F. ; McGeown, W. J. ; McKeith, I. ; Moretti, D. V. ; Nobili, F. ; Noce, G. ; Olichney, J. ; Onofrj, M. ; Osorio, R. ; Parra-Rodriguez, M. ; Rajji, T. ; Ritter, P. ; Soricelli, A. ; Stocchi, F. ; Tarnanas, I. ; Taylor, J. P. ; Teipel, S.DZNE* ; Tucci, F. ; Valdes-Sosa, M. ; Valdes-Sosa, P. ; Weiergräber, M. ; Yener, G. ; Guntekin, B.

2021
Wiley Hoboken, NJ

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/alz.12311

Abstract: The Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. The Panel reviewed the field literature. As most consistent findings, AD patients with mild cognitive impairment and dementia showed abnormalities in peak frequency, power, and 'interrelatedness' at posterior alpha (8-12 Hz) and widespread delta (< 4 Hz) and theta (4-8 Hz) rhythms in relation to disease progression and interventions. The following consensus statements were subscribed: (1) Standardization of instructions to patients, resting state EEG (rsEEG) recording methods, and selection of artifact-free rsEEG periods are needed; (2) power density and 'interrelatedness' rsEEG measures (e.g., directed transfer function, phase lag index, linear lagged connectivity, etc.) at delta, theta, and alpha frequency bands may be use for stratification of AD patients and monitoring of disease progression and intervention; and (3) international multisectoral initiatives are mandatory for regulatory purposes.

Keyword(s): Alzheimer Disease: physiopathology (MeSH) ; Brain: physiopathology (MeSH) ; Clinical Trials as Topic (MeSH) ; Cognitive Dysfunction: physiopathology (MeSH) ; Disease Progression (MeSH) ; Electroencephalography: standards (MeSH) ; Humans (MeSH) ; Alzheimer's disease ; The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) ; biomarkers ; clinical trials ; dementia ; electroencephalography (EEG) ; eyes-closed resting state condition

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Contributing Institute(s):

1. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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