%0 Journal Article
%A Pirlich, Mandy
%A Höfer, Cathleen
%A Weise, Christopher M
%A Stockert, Anika
%A Thöne-Otto, Angelika
%A Garthe, Alexander
%A Schob, Stefan
%A Classen, Joseph
%A Hoffmann, Karl-Titus
%A Saur, Dorothee
%T Hippocampal gray matter volume in the long-term course after transient global amnesia.
%J NeuroImage: Clinical
%V 30
%@ 2213-1582
%C [Amsterdam u.a.]
%I Elsevier
%M DZNE-2021-00805
%P 102586
%D 2021
%X In this retrospective, cross-sectional study we aimed to examine long-term memory deficits and gray matter volumes (GMV) in the hippocampus after transient global amnesia (TGA).20 patients with a history of TGA (TGA+, mean 6.5 years after TGA) and 20 age-matched healthy controls (TGA-) underwent neurocognitive assessment (i.e. Mini-Mental State Examination (MMSE), visuospatial, verbal and episodic autobiographical memory and visuospatial learning/navigation ['human water maze']) in combination with structural cerebral MRI. Voxel-based morphometry (VBM) was used to detect GMV in the hippocampus in TGA+ versus TGA-.Besides slight differences in MMSE and visuo-spatial learning/navigation measured with a human water maze in TGA+ vs. TGA-, no other tests of visuo-spatial, verbal and autobiographical long-term memory differed between groups. VBM analyses yielded a statistically significant difference in bilateral hippocampal GMV with TGA+ compared to TGA- showing greater GMV in a region corresponding to bilateral CA1. However, none of the hippocampus-dependent cognitive measures correlated with hippocampal GMV.In the long-term course after TGA, only subtle neurocognitive deficits without microstructural damage of the hippocampus could be detected. Greater GMV in bilateral hippocampus in TGA+ vs. TGA- may indicate that TGA triggers hippocampal GMV increase rather than atrophy.
%K Amnesia, Transient Global: diagnostic imaging
%K Cross-Sectional Studies
%K Gray Matter: diagnostic imaging
%K Hippocampus: diagnostic imaging
%K Humans
%K Magnetic Resonance Imaging
%K Retrospective Studies
%K Gray matter volume (Other)
%K Memory deficits (Other)
%K Voxel-based morphometry (Other)
%K Water maze (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33621769
%2 pmc:PMC7907892
%R 10.1016/j.nicl.2021.102586
%U https://pub.dzne.de/record/155637