Journal Article

DZNE-2021-00805

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Hippocampal gray matter volume in the long-term course after transient global amnesia.

Pirlich, M. ; Höfer, C. ; Weise, C. M. ; Stockert, A. ; Thöne-Otto, A. ; Garthe, A.DZNE* ; Schob, S. ; Classen, J. ; Hoffmann, K.-T. ; Saur, D. (Corresponding author)

2021
Elsevier [Amsterdam u.a.]

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Please use a persistent id in citations: doi:10.1016/j.nicl.2021.102586

Abstract: In this retrospective, cross-sectional study we aimed to examine long-term memory deficits and gray matter volumes (GMV) in the hippocampus after transient global amnesia (TGA).20 patients with a history of TGA (TGA+, mean 6.5 years after TGA) and 20 age-matched healthy controls (TGA-) underwent neurocognitive assessment (i.e. Mini-Mental State Examination (MMSE), visuospatial, verbal and episodic autobiographical memory and visuospatial learning/navigation ['human water maze']) in combination with structural cerebral MRI. Voxel-based morphometry (VBM) was used to detect GMV in the hippocampus in TGA+ versus TGA-.Besides slight differences in MMSE and visuo-spatial learning/navigation measured with a human water maze in TGA+ vs. TGA-, no other tests of visuo-spatial, verbal and autobiographical long-term memory differed between groups. VBM analyses yielded a statistically significant difference in bilateral hippocampal GMV with TGA+ compared to TGA- showing greater GMV in a region corresponding to bilateral CA1. However, none of the hippocampus-dependent cognitive measures correlated with hippocampal GMV.In the long-term course after TGA, only subtle neurocognitive deficits without microstructural damage of the hippocampus could be detected. Greater GMV in bilateral hippocampus in TGA+ vs. TGA- may indicate that TGA triggers hippocampal GMV increase rather than atrophy.

Keyword(s): Amnesia, Transient Global: diagnostic imaging (MeSH) ; Cross-Sectional Studies (MeSH) ; Gray Matter: diagnostic imaging (MeSH) ; Hippocampus: diagnostic imaging (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Retrospective Studies (MeSH) ; Gray matter volume ; Memory deficits ; Voxel-based morphometry ; Water maze

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Contributing Institute(s):

1. Technology Platform Neurobiology of Behaviour (AG Garthe)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2021

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