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000155637 0247_ $$2doi$$a10.1016/j.nicl.2021.102586
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000155637 041__ $$aEnglish
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000155637 1001_ $$aPirlich, Mandy$$b0
000155637 245__ $$aHippocampal gray matter volume in the long-term course after transient global amnesia.
000155637 260__ $$a[Amsterdam u.a.]$$bElsevier$$c2021
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000155637 520__ $$aIn this retrospective, cross-sectional study we aimed to examine long-term memory deficits and gray matter volumes (GMV) in the hippocampus after transient global amnesia (TGA).20 patients with a history of TGA (TGA+, mean 6.5 years after TGA) and 20 age-matched healthy controls (TGA-) underwent neurocognitive assessment (i.e. Mini-Mental State Examination (MMSE), visuospatial, verbal and episodic autobiographical memory and visuospatial learning/navigation ['human water maze']) in combination with structural cerebral MRI. Voxel-based morphometry (VBM) was used to detect GMV in the hippocampus in TGA+ versus TGA-.Besides slight differences in MMSE and visuo-spatial learning/navigation measured with a human water maze in TGA+ vs. TGA-, no other tests of visuo-spatial, verbal and autobiographical long-term memory differed between groups. VBM analyses yielded a statistically significant difference in bilateral hippocampal GMV with TGA+ compared to TGA- showing greater GMV in a region corresponding to bilateral CA1. However, none of the hippocampus-dependent cognitive measures correlated with hippocampal GMV.In the long-term course after TGA, only subtle neurocognitive deficits without microstructural damage of the hippocampus could be detected. Greater GMV in bilateral hippocampus in TGA+ vs. TGA- may indicate that TGA triggers hippocampal GMV increase rather than atrophy.
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000155637 650_7 $$2Other$$aGray matter volume
000155637 650_7 $$2Other$$aMemory deficits
000155637 650_7 $$2Other$$aVoxel-based morphometry
000155637 650_7 $$2Other$$aWater maze
000155637 650_2 $$2MeSH$$aAmnesia, Transient Global: diagnostic imaging
000155637 650_2 $$2MeSH$$aCross-Sectional Studies
000155637 650_2 $$2MeSH$$aGray Matter: diagnostic imaging
000155637 650_2 $$2MeSH$$aHippocampus: diagnostic imaging
000155637 650_2 $$2MeSH$$aHumans
000155637 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000155637 650_2 $$2MeSH$$aRetrospective Studies
000155637 7001_ $$aHöfer, Cathleen$$b1
000155637 7001_ $$aWeise, Christopher M$$b2
000155637 7001_ $$aStockert, Anika$$b3
000155637 7001_ $$aThöne-Otto, Angelika$$b4
000155637 7001_ $$0P:(DE-2719)2810535$$aGarthe, Alexander$$b5$$udzne
000155637 7001_ $$aSchob, Stefan$$b6
000155637 7001_ $$aClassen, Joseph$$b7
000155637 7001_ $$aHoffmann, Karl-Titus$$b8
000155637 7001_ $$0P:(DE-HGF)0$$aSaur, Dorothee$$b9$$eCorresponding author
000155637 773__ $$0PERI:(DE-600)2701571-3$$a10.1016/j.nicl.2021.102586$$gVol. 30, p. 102586 -$$p102586$$tNeuroImage: Clinical$$v30$$x2213-1582$$y2021
000155637 8564_ $$uhttps://www.sciencedirect.com/science/article/pii/S2213158221000309?via%3Dihub
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