TY  - JOUR
AU  - Pirlich, Mandy
AU  - Höfer, Cathleen
AU  - Weise, Christopher M
AU  - Stockert, Anika
AU  - Thöne-Otto, Angelika
AU  - Garthe, Alexander
AU  - Schob, Stefan
AU  - Classen, Joseph
AU  - Hoffmann, Karl-Titus
AU  - Saur, Dorothee
TI  - Hippocampal gray matter volume in the long-term course after transient global amnesia.
JO  - NeuroImage: Clinical
VL  - 30
SN  - 2213-1582
CY  - [Amsterdam u.a.]
PB  - Elsevier
M1  - DZNE-2021-00805
SP  - 102586
PY  - 2021
AB  - In this retrospective, cross-sectional study we aimed to examine long-term memory deficits and gray matter volumes (GMV) in the hippocampus after transient global amnesia (TGA).20 patients with a history of TGA (TGA+, mean 6.5 years after TGA) and 20 age-matched healthy controls (TGA-) underwent neurocognitive assessment (i.e. Mini-Mental State Examination (MMSE), visuospatial, verbal and episodic autobiographical memory and visuospatial learning/navigation ['human water maze']) in combination with structural cerebral MRI. Voxel-based morphometry (VBM) was used to detect GMV in the hippocampus in TGA+ versus TGA-.Besides slight differences in MMSE and visuo-spatial learning/navigation measured with a human water maze in TGA+ vs. TGA-, no other tests of visuo-spatial, verbal and autobiographical long-term memory differed between groups. VBM analyses yielded a statistically significant difference in bilateral hippocampal GMV with TGA+ compared to TGA- showing greater GMV in a region corresponding to bilateral CA1. However, none of the hippocampus-dependent cognitive measures correlated with hippocampal GMV.In the long-term course after TGA, only subtle neurocognitive deficits without microstructural damage of the hippocampus could be detected. Greater GMV in bilateral hippocampus in TGA+ vs. TGA- may indicate that TGA triggers hippocampal GMV increase rather than atrophy.
KW  - Amnesia, Transient Global: diagnostic imaging
KW  - Cross-Sectional Studies
KW  - Gray Matter: diagnostic imaging
KW  - Hippocampus: diagnostic imaging
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Retrospective Studies
KW  - Gray matter volume (Other)
KW  - Memory deficits (Other)
KW  - Voxel-based morphometry (Other)
KW  - Water maze (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33621769
C2  - pmc:PMC7907892
DO  - DOI:10.1016/j.nicl.2021.102586
UR  - https://pub.dzne.de/record/155637
ER  -