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@ARTICLE{Pirlich:155637,
      author       = {Pirlich, Mandy and Höfer, Cathleen and Weise, Christopher
                      M and Stockert, Anika and Thöne-Otto, Angelika and Garthe,
                      Alexander and Schob, Stefan and Classen, Joseph and
                      Hoffmann, Karl-Titus and Saur, Dorothee},
      title        = {{H}ippocampal gray matter volume in the long-term course
                      after transient global amnesia.},
      journal      = {NeuroImage: Clinical},
      volume       = {30},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-00805},
      pages        = {102586},
      year         = {2021},
      abstract     = {In this retrospective, cross-sectional study we aimed to
                      examine long-term memory deficits and gray matter volumes
                      (GMV) in the hippocampus after transient global amnesia
                      (TGA).20 patients with a history of TGA (TGA+, mean
                      6.5 years after TGA) and 20 age-matched healthy controls
                      (TGA-) underwent neurocognitive assessment (i.e. Mini-Mental
                      State Examination (MMSE), visuospatial, verbal and episodic
                      autobiographical memory and visuospatial learning/navigation
                      ['human water maze']) in combination with structural
                      cerebral MRI. Voxel-based morphometry (VBM) was used to
                      detect GMV in the hippocampus in TGA+ versus TGA-.Besides
                      slight differences in MMSE and visuo-spatial
                      learning/navigation measured with a human water maze in
                      TGA+ vs. TGA-, no other tests of visuo-spatial, verbal and
                      autobiographical long-term memory differed between groups.
                      VBM analyses yielded a statistically significant difference
                      in bilateral hippocampal GMV with TGA+ compared to TGA-
                      showing greater GMV in a region corresponding to bilateral
                      CA1. However, none of the hippocampus-dependent cognitive
                      measures correlated with hippocampal GMV.In the long-term
                      course after TGA, only subtle neurocognitive deficits
                      without microstructural damage of the hippocampus could be
                      detected. Greater GMV in bilateral hippocampus in TGA+ vs.
                      TGA- may indicate that TGA triggers hippocampal GMV increase
                      rather than atrophy.},
      keywords     = {Amnesia, Transient Global: diagnostic imaging /
                      Cross-Sectional Studies / Gray Matter: diagnostic imaging /
                      Hippocampus: diagnostic imaging / Humans / Magnetic
                      Resonance Imaging / Retrospective Studies / Gray matter
                      volume (Other) / Memory deficits (Other) / Voxel-based
                      morphometry (Other) / Water maze (Other)},
      cin          = {AG Garthe},
      ddc          = {610},
      cid          = {I:(DE-2719)1740001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33621769},
      pmc          = {pmc:PMC7907892},
      doi          = {10.1016/j.nicl.2021.102586},
      url          = {https://pub.dzne.de/record/155637},
}