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001     155637
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024 7 _ |a 10.1016/j.nicl.2021.102586
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082 _ _ |a 610
100 1 _ |a Pirlich, Mandy
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245 _ _ |a Hippocampal gray matter volume in the long-term course after transient global amnesia.
260 _ _ |a [Amsterdam u.a.]
|c 2021
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520 _ _ |a In this retrospective, cross-sectional study we aimed to examine long-term memory deficits and gray matter volumes (GMV) in the hippocampus after transient global amnesia (TGA).20 patients with a history of TGA (TGA+, mean 6.5 years after TGA) and 20 age-matched healthy controls (TGA-) underwent neurocognitive assessment (i.e. Mini-Mental State Examination (MMSE), visuospatial, verbal and episodic autobiographical memory and visuospatial learning/navigation ['human water maze']) in combination with structural cerebral MRI. Voxel-based morphometry (VBM) was used to detect GMV in the hippocampus in TGA+ versus TGA-.Besides slight differences in MMSE and visuo-spatial learning/navigation measured with a human water maze in TGA+ vs. TGA-, no other tests of visuo-spatial, verbal and autobiographical long-term memory differed between groups. VBM analyses yielded a statistically significant difference in bilateral hippocampal GMV with TGA+ compared to TGA- showing greater GMV in a region corresponding to bilateral CA1. However, none of the hippocampus-dependent cognitive measures correlated with hippocampal GMV.In the long-term course after TGA, only subtle neurocognitive deficits without microstructural damage of the hippocampus could be detected. Greater GMV in bilateral hippocampus in TGA+ vs. TGA- may indicate that TGA triggers hippocampal GMV increase rather than atrophy.
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650 _ 7 |a Gray matter volume
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650 _ 7 |a Memory deficits
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650 _ 7 |a Voxel-based morphometry
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650 _ 7 |a Water maze
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650 _ 2 |a Amnesia, Transient Global: diagnostic imaging
|2 MeSH
650 _ 2 |a Cross-Sectional Studies
|2 MeSH
650 _ 2 |a Gray Matter: diagnostic imaging
|2 MeSH
650 _ 2 |a Hippocampus: diagnostic imaging
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Retrospective Studies
|2 MeSH
700 1 _ |a Höfer, Cathleen
|b 1
700 1 _ |a Weise, Christopher M
|b 2
700 1 _ |a Stockert, Anika
|b 3
700 1 _ |a Thöne-Otto, Angelika
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700 1 _ |a Garthe, Alexander
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700 1 _ |a Schob, Stefan
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700 1 _ |a Classen, Joseph
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700 1 _ |a Hoffmann, Karl-Titus
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700 1 _ |a Saur, Dorothee
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773 _ _ |a 10.1016/j.nicl.2021.102586
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856 4 _ |u https://www.sciencedirect.com/science/article/pii/S2213158221000309?via%3Dihub
856 4 _ |u https://pub.dzne.de/record/155637/files/DZNE-2021-00805.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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