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000155664 0247_ $$2doi$$a10.1016/j.neurobiolaging.2021.04.014
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000155664 0247_ $$2ISSN$$a1558-1497
000155664 037__ $$aDZNE-2021-00832
000155664 041__ $$aEnglish
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000155664 1001_ $$0P:(DE-2719)2814244$$aHofmann, Anna$$b0$$eFirst author$$udzne
000155664 245__ $$aAbnormally reduced frontal cortex activity during Trail-Making-Test in prodromal parkinson's disease-a fNIRS study.
000155664 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2021
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000155664 520__ $$aParkinson's Disease (PD) is a neurodegenerative disorder leading to typical motor as well as a range of non-motor symptoms, including cognitive decline mainly characterized by executive deficits. The latter are known to appear years before the typical motor signs, thus representing the prodromal phase of PD. However, appropriate methods for measuring executive dysfunction in this context are not well established yet. Traditionally, executive performance is associated with frontal structures. Here, we investigated prodromal, early PD patients and healthy controls regarding their executive functioning on the behavioral and neural level, measured by the Trail-Making-Test (TMT) combined with functional near-infrared spectroscopy. We observed significantly reduced neural activity in the right dorsolateral prefrontal cortex within PD patients compared to controls completing the TMT-A and -B in contrast to the TMT-C, but no differences on a behavioral level. These promising results need to be confirmed and checked for reliability in future studies to extend the spectrum of markers applied in prodromal PD.
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000155664 650_7 $$2Other$$aExecutive dysfunction
000155664 650_7 $$2Other$$aFunctional Near-Infrared Spectroscopy (fNIRS)
000155664 650_7 $$2Other$$aParkinson's disease
000155664 650_7 $$2Other$$aProdromal stage
000155664 650_2 $$2MeSH$$aAged
000155664 650_2 $$2MeSH$$aExecutive Function
000155664 650_2 $$2MeSH$$aFemale
000155664 650_2 $$2MeSH$$aFrontal Lobe: physiopathology
000155664 650_2 $$2MeSH$$aHumans
000155664 650_2 $$2MeSH$$aMale
000155664 650_2 $$2MeSH$$aNeuropsychological Tests
000155664 650_2 $$2MeSH$$aParkinson Disease: physiopathology
000155664 650_2 $$2MeSH$$aParkinson Disease: psychology
000155664 650_2 $$2MeSH$$aReproducibility of Results
000155664 650_2 $$2MeSH$$aSpectroscopy, Near-Infrared
000155664 7001_ $$aRosenbaum, David$$b1
000155664 7001_ $$aInt-Veen, Isabell$$b2
000155664 7001_ $$aEhlis, Ann-Christine$$b3
000155664 7001_ $$0P:(DE-2719)2811916$$aBrockmann, Kathrin$$b4$$udzne
000155664 7001_ $$aDehnen, Katja$$b5
000155664 7001_ $$0P:(DE-2719)2814099$$avon Thaler, Anna-Katharina$$b6$$udzne
000155664 7001_ $$0P:(DE-2719)2000059$$aBerg, Daniela$$b7$$udzne
000155664 7001_ $$0P:(DE-2719)2811701$$aFallgatter, Andreas J$$b8$$udzne
000155664 7001_ $$0P:(DE-2719)9001194$$aMetzger, Florian$$b9$$udzne
000155664 7001_ $$aConsortium, TREND Study$$b10$$eCollaboration Author
000155664 773__ $$0PERI:(DE-600)1498414-3$$a10.1016/j.neurobiolaging.2021.04.014$$gVol. 105, p. 148 - 158$$p148 - 158$$tNeurobiology of aging$$v105$$x0197-4580$$y2021
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