TY  - JOUR
AU  - Hofmann, Anna
AU  - Rosenbaum, David
AU  - Int-Veen, Isabell
AU  - Ehlis, Ann-Christine
AU  - Brockmann, Kathrin
AU  - Dehnen, Katja
AU  - von Thaler, Anna-Katharina
AU  - Berg, Daniela
AU  - Fallgatter, Andreas J
AU  - Metzger, Florian
TI  - Abnormally reduced frontal cortex activity during Trail-Making-Test in prodromal parkinson's disease-a fNIRS study.
JO  - Neurobiology of aging
VL  - 105
SN  - 0197-4580
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2021-00832
SP  - 148 - 158
PY  - 2021
AB  - Parkinson's Disease (PD) is a neurodegenerative disorder leading to typical motor as well as a range of non-motor symptoms, including cognitive decline mainly characterized by executive deficits. The latter are known to appear years before the typical motor signs, thus representing the prodromal phase of PD. However, appropriate methods for measuring executive dysfunction in this context are not well established yet. Traditionally, executive performance is associated with frontal structures. Here, we investigated prodromal, early PD patients and healthy controls regarding their executive functioning on the behavioral and neural level, measured by the Trail-Making-Test (TMT) combined with functional near-infrared spectroscopy. We observed significantly reduced neural activity in the right dorsolateral prefrontal cortex within PD patients compared to controls completing the TMT-A and -B in contrast to the TMT-C, but no differences on a behavioral level. These promising results need to be confirmed and checked for reliability in future studies to extend the spectrum of markers applied in prodromal PD.
KW  - Aged
KW  - Executive Function
KW  - Female
KW  - Frontal Lobe: physiopathology
KW  - Humans
KW  - Male
KW  - Neuropsychological Tests
KW  - Parkinson Disease: physiopathology
KW  - Parkinson Disease: psychology
KW  - Reproducibility of Results
KW  - Spectroscopy, Near-Infrared
KW  - Executive dysfunction (Other)
KW  - Functional Near-Infrared Spectroscopy (fNIRS) (Other)
KW  - Parkinson's disease (Other)
KW  - Prodromal stage (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34087607
DO  - DOI:10.1016/j.neurobiolaging.2021.04.014
UR  - https://pub.dzne.de/record/155664
ER  -