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@ARTICLE{Hofmann:155664,
      author       = {Hofmann, Anna and Rosenbaum, David and Int-Veen, Isabell
                      and Ehlis, Ann-Christine and Brockmann, Kathrin and Dehnen,
                      Katja and von Thaler, Anna-Katharina and Berg, Daniela and
                      Fallgatter, Andreas J and Metzger, Florian},
      collaboration = {Consortium, TREND Study},
      title        = {{A}bnormally reduced frontal cortex activity during
                      {T}rail-{M}aking-{T}est in prodromal parkinson's disease-a
                      f{NIRS} study.},
      journal      = {Neurobiology of aging},
      volume       = {105},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2021-00832},
      pages        = {148 - 158},
      year         = {2021},
      abstract     = {Parkinson's Disease (PD) is a neurodegenerative disorder
                      leading to typical motor as well as a range of non-motor
                      symptoms, including cognitive decline mainly characterized
                      by executive deficits. The latter are known to appear years
                      before the typical motor signs, thus representing the
                      prodromal phase of PD. However, appropriate methods for
                      measuring executive dysfunction in this context are not well
                      established yet. Traditionally, executive performance is
                      associated with frontal structures. Here, we investigated
                      prodromal, early PD patients and healthy controls regarding
                      their executive functioning on the behavioral and neural
                      level, measured by the Trail-Making-Test (TMT) combined with
                      functional near-infrared spectroscopy. We observed
                      significantly reduced neural activity in the right
                      dorsolateral prefrontal cortex within PD patients compared
                      to controls completing the TMT-A and -B in contrast to the
                      TMT-C, but no differences on a behavioral level. These
                      promising results need to be confirmed and checked for
                      reliability in future studies to extend the spectrum of
                      markers applied in prodromal PD.},
      keywords     = {Aged / Executive Function / Female / Frontal Lobe:
                      physiopathology / Humans / Male / Neuropsychological Tests /
                      Parkinson Disease: physiopathology / Parkinson Disease:
                      psychology / Reproducibility of Results / Spectroscopy,
                      Near-Infrared / Executive dysfunction (Other) / Functional
                      Near-Infrared Spectroscopy (fNIRS) (Other) / Parkinson's
                      disease (Other) / Prodromal stage (Other)},
      cin          = {Core ICRU / AG Gasser 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1240005 / I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34087607},
      doi          = {10.1016/j.neurobiolaging.2021.04.014},
      url          = {https://pub.dzne.de/record/155664},
}