Home > Publications Database > Abnormally reduced frontal cortex activity during Trail-Making-Test in prodromal parkinson's disease-a fNIRS study. > print

001     155664
005     20230915092335.0
024 7 _ |a 10.1016/j.neurobiolaging.2021.04.014
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024 7 _ |a 0197-4580
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024 7 _ |a 1558-1497
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037 _ _ |a DZNE-2021-00832
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Hofmann, Anna
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245 _ _ |a Abnormally reduced frontal cortex activity during Trail-Making-Test in prodromal parkinson's disease-a fNIRS study.
260 _ _ |a Amsterdam [u.a.]
|c 2021
|b Elsevier Science
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520 _ _ |a Parkinson's Disease (PD) is a neurodegenerative disorder leading to typical motor as well as a range of non-motor symptoms, including cognitive decline mainly characterized by executive deficits. The latter are known to appear years before the typical motor signs, thus representing the prodromal phase of PD. However, appropriate methods for measuring executive dysfunction in this context are not well established yet. Traditionally, executive performance is associated with frontal structures. Here, we investigated prodromal, early PD patients and healthy controls regarding their executive functioning on the behavioral and neural level, measured by the Trail-Making-Test (TMT) combined with functional near-infrared spectroscopy. We observed significantly reduced neural activity in the right dorsolateral prefrontal cortex within PD patients compared to controls completing the TMT-A and -B in contrast to the TMT-C, but no differences on a behavioral level. These promising results need to be confirmed and checked for reliability in future studies to extend the spectrum of markers applied in prodromal PD.
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650 _ 7 |a Executive dysfunction
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650 _ 7 |a Functional Near-Infrared Spectroscopy (fNIRS)
|2 Other
650 _ 7 |a Parkinson's disease
|2 Other
650 _ 7 |a Prodromal stage
|2 Other
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Executive Function
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Frontal Lobe: physiopathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Neuropsychological Tests
|2 MeSH
650 _ 2 |a Parkinson Disease: physiopathology
|2 MeSH
650 _ 2 |a Parkinson Disease: psychology
|2 MeSH
650 _ 2 |a Reproducibility of Results
|2 MeSH
650 _ 2 |a Spectroscopy, Near-Infrared
|2 MeSH
700 1 _ |a Rosenbaum, David
|b 1
700 1 _ |a Int-Veen, Isabell
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700 1 _ |a Ehlis, Ann-Christine
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700 1 _ |a Brockmann, Kathrin
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700 1 _ |a Dehnen, Katja
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700 1 _ |a von Thaler, Anna-Katharina
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700 1 _ |a Berg, Daniela
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700 1 _ |a Fallgatter, Andreas J
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700 1 _ |a Metzger, Florian
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700 1 _ |a Consortium, TREND Study
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773 _ _ |a 10.1016/j.neurobiolaging.2021.04.014
|g Vol. 105, p. 148 - 158
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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