%0 Journal Article
%A Cuellar-Partida, Gabriel
%A Tung, Joyce Y
%A Eriksson, Nicholas
%A Albrecht, Eva
%A Aliev, Fazil
%A Andreassen, Ole A
%A Barroso, Inês
%A Beckmann, Jacques S
%A Boks, Marco P
%A Boomsma, Dorret I
%A Boyd, Heather A
%A Breteler, Monique
%A Campbell, Harry
%A Chasman, Daniel I
%A Cherkas, Lynn F
%A Davies, Gail
%A de Geus, Eco J C
%A Deary, Ian J
%A Deloukas, Panos
%A Dick, Danielle M
%A Duffy, David L
%A Eriksson, Johan G
%A Esko, Tõnu
%A Feenstra, Bjarke
%A Geller, Frank
%A Gieger, Christian
%A Giegling, Ina
%A Gordon, Scott D
%A Han, Jiali
%A Hansen, Thomas F
%A Hartmann, Annette M
%A Hayward, Caroline
%A Heikkilä, Kauko
%A Hicks, Andrew A
%A Hirschhorn, Joel N
%A Hottenga, Jouke-Jan
%A Huffman, Jennifer E
%A Hwang, Liang-Dar
%A Ikram, M Arfan
%A Kaprio, Jaakko
%A Kemp, John P
%A Khaw, Kay-Tee
%A Klopp, Norman
%A Konte, Bettina
%A Kutalik, Zoltan
%A Lahti, Jari
%A Li, Xin
%A Loos, Ruth J F
%A Luciano, Michelle
%A Magnusson, Sigurdur H
%A Mangino, Massimo
%A Marques-Vidal, Pedro
%A Martin, Nicholas G
%A McArdle, Wendy L
%A McCarthy, Mark I
%A Medina-Gomez, Carolina
%A Melbye, Mads
%A Melville, Scott A
%A Metspalu, Andres
%A Milani, Lili
%A Mooser, Vincent
%A Nelis, Mari
%A Nyholt, Dale R
%A O'Connell, Kevin S
%A Ophoff, Roel A
%A Palmer, Cameron
%A Palotie, Aarno
%A Palviainen, Teemu
%A Pare, Guillaume
%A Paternoster, Lavinia
%A Peltonen, Leena
%A Penninx, Brenda W J H
%A Polasek, Ozren
%A Pramstaller, Peter P
%A Prokopenko, Inga
%A Raikkonen, Katri
%A Ripatti, Samuli
%A Rivadeneira, Fernando
%A Rudan, Igor
%A Rujescu, Dan
%A Smit, Johannes H
%A Smith, George Davey
%A Smoller, Jordan W
%A Soranzo, Nicole
%A Spector, Tim D
%A Pourcain, Beate St
%A Starr, John M
%A Stefánsson, Hreinn
%A Steinberg, Stacy
%A Teder-Laving, Maris
%A Thorleifsson, Gudmar
%A Stefánsson, Kári
%A Timpson, Nicholas J
%A Uitterlinden, André G
%A van Duijn, Cornelia M
%A van Rooij, Frank J A
%A Vink, Jaqueline M
%A Vollenweider, Peter
%A Vuoksimaa, Eero
%A Waeber, Gérard
%A Wareham, Nicholas J
%A Warrington, Nicole
%A Waterworth, Dawn
%A Werge, Thomas
%A Wichmann, H-Erich
%A Widen, Elisabeth
%A Willemsen, Gonneke
%A Wright, Alan F
%A Wright, Margaret J
%A Xu, Mousheng
%A Zhao, Jing Hua
%A Kraft, Peter
%A Hinds, David A
%A Lindgren, Cecilia M
%A Mägi, Reedik
%A Neale, Benjamin M
%A Evans, David M
%A Medland, Sarah E
%T Genome-wide association study identifies 48 common genetic variants associated with handedness.
%J Nature human behaviour
%V 5
%N 1
%@ 2397-3374
%C London
%I Nature Research
%M DZNE-2021-00872
%P 59 - 70
%D 2021
%X Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
%K Adult
%K Aged
%K Female
%K Functional Laterality: genetics
%K Gene Frequency: genetics
%K Genetic Loci: genetics
%K Genetic Variation: genetics
%K Genome-Wide Association Study
%K Humans
%K Linkage Disequilibrium
%K Male
%K Middle Aged
%K Polymorphism, Single Nucleotide: genetics
%K Quantitative Trait, Heritable
%K Sex Factors
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32989287
%2 pmc:PMC7116623
%R 10.1038/s41562-020-00956-y
%U https://pub.dzne.de/record/155704