Journal Article

DZNE-2021-00872

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genome-wide association study identifies 48 common genetic variants associated with handedness.

Cuellar-Partida, G. ; Tung, J. Y. ; Eriksson, N. ; Albrecht, E. ; Aliev, F. ; Andreassen, O. A.Extern* ; Barroso, I. ; Beckmann, J. S. ; Boks, M. P. ; Boomsma, D. I. ; Boyd, H. A. ; Breteler, M.DZNE* ; Campbell, H. ; Chasman, D. I. ; Cherkas, L. F. ; Davies, G. ; de Geus, E. J. C. ; Deary, I. J. ; Deloukas, P. ; Dick, D. M. ; Duffy, D. L. ; Eriksson, J. G. ; Esko, T. ; Feenstra, B. ; Geller, F. ; Gieger, C. ; Giegling, I. ; Gordon, S. D. ; Han, J. ; Hansen, T. F. ; Hartmann, A. M. ; Hayward, C. ; Heikkilä, K. ; Hicks, A. A. ; Hirschhorn, J. N. ; Hottenga, J.-J. ; Huffman, J. E. ; Hwang, L.-D. ; Ikram, M. A. ; Kaprio, J. ; Kemp, J. P. ; Khaw, K.-T. ; Klopp, N. ; Konte, B. ; Kutalik, Z. ; Lahti, J. ; Li, X. ; Loos, R. J. F. ; Luciano, M. ; Magnusson, S. H. ; Mangino, M. ; Marques-Vidal, P. ; Martin, N. G. ; McArdle, W. L. ; McCarthy, M. I. ; Medina-Gomez, C. ; Melbye, M. ; Melville, S. A. ; Metspalu, A. ; Milani, L. ; Mooser, V. ; Nelis, M. ; Nyholt, D. R. ; O'Connell, K. S. ; Ophoff, R. A. ; Palmer, C. ; Palotie, A. ; Palviainen, T. ; Pare, G. ; Paternoster, L. ; Peltonen, L. ; Penninx, B. W. J. H. ; Polasek, O. ; Pramstaller, P. P. ; Prokopenko, I. ; Raikkonen, K. ; Ripatti, S. ; Rivadeneira, F. ; Rudan, I. ; Rujescu, D. ; Smit, J. H. ; Smith, G. D. ; Smoller, J. W. ; Soranzo, N. ; Spector, T. D. ; Pourcain, B. S. ; Starr, J. M. ; Stefánsson, H. ; Steinberg, S. ; Teder-Laving, M. ; Thorleifsson, G. ; Stefánsson, K. ; Timpson, N. J. ; Uitterlinden, A. G. ; van Duijn, C. M. ; van Rooij, F. J. A. ; Vink, J. M. ; Vollenweider, P. ; Vuoksimaa, E. ; Waeber, G. ; Wareham, N. J. ; Warrington, N. ; Waterworth, D. ; Werge, T. ; Wichmann, H.-E. ; Widen, E. ; Willemsen, G. ; Wright, A. F. ; Wright, M. J. ; Xu, M. ; Zhao, J. H. ; Kraft, P. ; Hinds, D. A. ; Lindgren, C. M. ; Mägi, R. ; Neale, B. M. ; Evans, D. M. ; Medland, S. E. (Corresponding author)

2021
Nature Research London

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Please use a persistent id in citations: doi:10.1038/s41562-020-00956-y

Abstract: Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.

Keyword(s): Adult (MeSH) ; Aged (MeSH) ; Female (MeSH) ; Functional Laterality: genetics (MeSH) ; Gene Frequency: genetics (MeSH) ; Genetic Loci: genetics (MeSH) ; Genetic Variation: genetics (MeSH) ; Genome-Wide Association Study (MeSH) ; Humans (MeSH) ; Linkage Disequilibrium (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Polymorphism, Single Nucleotide: genetics (MeSH) ; Quantitative Trait, Heritable (MeSH) ; Sex Factors (MeSH)

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Contributing Institute(s):

1. Population Health Sciences (AG Breteler 1)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Appears in the scientific report 2021

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Essential Science Indicators ; IF >= 20 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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