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000155704 0247_ $$2doi$$a10.1038/s41562-020-00956-y
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000155704 1001_ $$00000-0001-7648-4097$$aCuellar-Partida, Gabriel$$b0
000155704 245__ $$aGenome-wide association study identifies 48 common genetic variants associated with handedness.
000155704 260__ $$aLondon$$bNature Research$$c2021
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000155704 520__ $$aHandedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
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000155704 650_2 $$2MeSH$$aAdult
000155704 650_2 $$2MeSH$$aAged
000155704 650_2 $$2MeSH$$aFemale
000155704 650_2 $$2MeSH$$aFunctional Laterality: genetics
000155704 650_2 $$2MeSH$$aGene Frequency: genetics
000155704 650_2 $$2MeSH$$aGenetic Loci: genetics
000155704 650_2 $$2MeSH$$aGenetic Variation: genetics
000155704 650_2 $$2MeSH$$aGenome-Wide Association Study
000155704 650_2 $$2MeSH$$aHumans
000155704 650_2 $$2MeSH$$aLinkage Disequilibrium
000155704 650_2 $$2MeSH$$aMale
000155704 650_2 $$2MeSH$$aMiddle Aged
000155704 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide: genetics
000155704 650_2 $$2MeSH$$aQuantitative Trait, Heritable
000155704 650_2 $$2MeSH$$aSex Factors
000155704 7001_ $$aTung, Joyce Y$$b1
000155704 7001_ $$aEriksson, Nicholas$$b2
000155704 7001_ $$aAlbrecht, Eva$$b3
000155704 7001_ $$00000-0001-8357-4699$$aAliev, Fazil$$b4
000155704 7001_ $$0P:(DE-2719)9001146$$aAndreassen, Ole A$$b5$$udzne
000155704 7001_ $$00000-0001-5800-4520$$aBarroso, Inês$$b6
000155704 7001_ $$00000-0002-9741-1900$$aBeckmann, Jacques S$$b7
000155704 7001_ $$00000-0001-6163-7484$$aBoks, Marco P$$b8
000155704 7001_ $$00000-0002-7099-7972$$aBoomsma, Dorret I$$b9
000155704 7001_ $$00000-0001-6849-9985$$aBoyd, Heather A$$b10
000155704 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique$$b11$$udzne
000155704 7001_ $$aCampbell, Harry$$b12
000155704 7001_ $$00000-0003-3357-0862$$aChasman, Daniel I$$b13
000155704 7001_ $$aCherkas, Lynn F$$b14
000155704 7001_ $$aDavies, Gail$$b15
000155704 7001_ $$00000-0001-6022-2666$$ade Geus, Eco J C$$b16
000155704 7001_ $$00000-0002-1733-263X$$aDeary, Ian J$$b17
000155704 7001_ $$00000-0001-9251-070X$$aDeloukas, Panos$$b18
000155704 7001_ $$00000-0002-1636-893X$$aDick, Danielle M$$b19
000155704 7001_ $$aDuffy, David L$$b20
000155704 7001_ $$aEriksson, Johan G$$b21
000155704 7001_ $$aEsko, Tõnu$$b22
000155704 7001_ $$00000-0003-1478-649X$$aFeenstra, Bjarke$$b23
000155704 7001_ $$00000-0002-9238-3269$$aGeller, Frank$$b24
000155704 7001_ $$aGieger, Christian$$b25
000155704 7001_ $$aGiegling, Ina$$b26
000155704 7001_ $$00000-0001-7623-328X$$aGordon, Scott D$$b27
000155704 7001_ $$aHan, Jiali$$b28
000155704 7001_ $$00000-0001-6703-7762$$aHansen, Thomas F$$b29
000155704 7001_ $$aHartmann, Annette M$$b30
000155704 7001_ $$00000-0002-9405-9550$$aHayward, Caroline$$b31
000155704 7001_ $$aHeikkilä, Kauko$$b32
000155704 7001_ $$00000-0001-6320-0411$$aHicks, Andrew A$$b33
000155704 7001_ $$00000-0002-1650-7901$$aHirschhorn, Joel N$$b34
000155704 7001_ $$00000-0002-5668-2368$$aHottenga, Jouke-Jan$$b35
000155704 7001_ $$00000-0002-9672-2491$$aHuffman, Jennifer E$$b36
000155704 7001_ $$00000-0002-5535-2199$$aHwang, Liang-Dar$$b37
000155704 7001_ $$00000-0003-0372-8585$$aIkram, M Arfan$$b38
000155704 7001_ $$00000-0002-3716-2455$$aKaprio, Jaakko$$b39
000155704 7001_ $$00000-0002-9105-2249$$aKemp, John P$$b40
000155704 7001_ $$aKhaw, Kay-Tee$$b41
000155704 7001_ $$aKlopp, Norman$$b42
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000155704 7001_ $$00000-0001-8285-7523$$aKutalik, Zoltan$$b44
000155704 7001_ $$00000-0002-4310-5297$$aLahti, Jari$$b45
000155704 7001_ $$00000-0002-0135-8800$$aLi, Xin$$b46
000155704 7001_ $$00000-0002-8532-5087$$aLoos, Ruth J F$$b47
000155704 7001_ $$00000-0002-7306-3008$$aLuciano, Michelle$$b48
000155704 7001_ $$00000-0001-6669-3071$$aMagnusson, Sigurdur H$$b49
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000155704 7001_ $$00000-0002-4548-8500$$aMarques-Vidal, Pedro$$b51
000155704 7001_ $$00000-0003-4069-8020$$aMartin, Nicholas G$$b52
000155704 7001_ $$00000-0002-0605-5403$$aMcArdle, Wendy L$$b53
000155704 7001_ $$00000-0002-4393-0510$$aMcCarthy, Mark I$$b54
000155704 7001_ $$00000-0001-7999-5538$$aMedina-Gomez, Carolina$$b55
000155704 7001_ $$00000-0001-8264-6785$$aMelbye, Mads$$b56
000155704 7001_ $$aMelville, Scott A$$b57
000155704 7001_ $$00000-0002-3718-796X$$aMetspalu, Andres$$b58
000155704 7001_ $$00000-0002-5323-3102$$aMilani, Lili$$b59
000155704 7001_ $$aMooser, Vincent$$b60
000155704 7001_ $$00000-0001-9748-1020$$aNelis, Mari$$b61
000155704 7001_ $$00000-0001-7159-3040$$aNyholt, Dale R$$b62
000155704 7001_ $$00000-0002-6865-8795$$aO'Connell, Kevin S$$b63
000155704 7001_ $$00000-0002-8287-6457$$aOphoff, Roel A$$b64
000155704 7001_ $$aPalmer, Cameron$$b65
000155704 7001_ $$aPalotie, Aarno$$b66
000155704 7001_ $$00000-0002-7847-8384$$aPalviainen, Teemu$$b67
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000155704 7001_ $$aPramstaller, Peter P$$b73
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000155704 7001_ $$00000-0002-2062-8378$$aSmit, Johannes H$$b80
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000155704 7001_ $$00000-0002-0381-6334$$aSmoller, Jordan W$$b82
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000155704 7001_ $$00000-0002-7141-9189$$aTimpson, Nicholas J$$b92
000155704 7001_ $$00000-0002-7276-3387$$aUitterlinden, André G$$b93
000155704 7001_ $$avan Duijn, Cornelia M$$b94
000155704 7001_ $$00000-0002-8600-9852$$avan Rooij, Frank J A$$b95
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000155704 7001_ $$aVollenweider, Peter$$b97
000155704 7001_ $$aVuoksimaa, Eero$$b98
000155704 7001_ $$00000-0003-4193-788X$$aWaeber, Gérard$$b99
000155704 7001_ $$aWareham, Nicholas J$$b100
000155704 7001_ $$00000-0003-4195-775X$$aWarrington, Nicole$$b101
000155704 7001_ $$aWaterworth, Dawn$$b102
000155704 7001_ $$00000-0003-1829-0766$$aWerge, Thomas$$b103
000155704 7001_ $$aWichmann, H-Erich$$b104
000155704 7001_ $$aWiden, Elisabeth$$b105
000155704 7001_ $$aWillemsen, Gonneke$$b106
000155704 7001_ $$aWright, Alan F$$b107
000155704 7001_ $$00000-0001-7133-4970$$aWright, Margaret J$$b108
000155704 7001_ $$aXu, Mousheng$$b109
000155704 7001_ $$00000-0002-1463-5870$$aZhao, Jing Hua$$b110
000155704 7001_ $$00000-0002-4472-8103$$aKraft, Peter$$b111
000155704 7001_ $$00000-0002-4911-803X$$aHinds, David A$$b112
000155704 7001_ $$00000-0002-4903-9374$$aLindgren, Cecilia M$$b113
000155704 7001_ $$aMägi, Reedik$$b114
000155704 7001_ $$00000-0003-1513-6077$$aNeale, Benjamin M$$b115
000155704 7001_ $$00000-0003-0663-4621$$aEvans, David M$$b116
000155704 7001_ $$00000-0003-1382-380X$$aMedland, Sarah E$$b117$$eCorresponding author
000155704 773__ $$0PERI:(DE-600)2885046-4$$a10.1038/s41562-020-00956-y$$gVol. 5, no. 1, p. 59 - 70$$n1$$p59 - 70$$tNature human behaviour$$v5$$x2397-3374$$y2021
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