TY  - JOUR
AU  - Cuellar-Partida, Gabriel
AU  - Tung, Joyce Y
AU  - Eriksson, Nicholas
AU  - Albrecht, Eva
AU  - Aliev, Fazil
AU  - Andreassen, Ole A
AU  - Barroso, Inês
AU  - Beckmann, Jacques S
AU  - Boks, Marco P
AU  - Boomsma, Dorret I
AU  - Boyd, Heather A
AU  - Breteler, Monique
AU  - Campbell, Harry
AU  - Chasman, Daniel I
AU  - Cherkas, Lynn F
AU  - Davies, Gail
AU  - de Geus, Eco J C
AU  - Deary, Ian J
AU  - Deloukas, Panos
AU  - Dick, Danielle M
AU  - Duffy, David L
AU  - Eriksson, Johan G
AU  - Esko, Tõnu
AU  - Feenstra, Bjarke
AU  - Geller, Frank
AU  - Gieger, Christian
AU  - Giegling, Ina
AU  - Gordon, Scott D
AU  - Han, Jiali
AU  - Hansen, Thomas F
AU  - Hartmann, Annette M
AU  - Hayward, Caroline
AU  - Heikkilä, Kauko
AU  - Hicks, Andrew A
AU  - Hirschhorn, Joel N
AU  - Hottenga, Jouke-Jan
AU  - Huffman, Jennifer E
AU  - Hwang, Liang-Dar
AU  - Ikram, M Arfan
AU  - Kaprio, Jaakko
AU  - Kemp, John P
AU  - Khaw, Kay-Tee
AU  - Klopp, Norman
AU  - Konte, Bettina
AU  - Kutalik, Zoltan
AU  - Lahti, Jari
AU  - Li, Xin
AU  - Loos, Ruth J F
AU  - Luciano, Michelle
AU  - Magnusson, Sigurdur H
AU  - Mangino, Massimo
AU  - Marques-Vidal, Pedro
AU  - Martin, Nicholas G
AU  - McArdle, Wendy L
AU  - McCarthy, Mark I
AU  - Medina-Gomez, Carolina
AU  - Melbye, Mads
AU  - Melville, Scott A
AU  - Metspalu, Andres
AU  - Milani, Lili
AU  - Mooser, Vincent
AU  - Nelis, Mari
AU  - Nyholt, Dale R
AU  - O'Connell, Kevin S
AU  - Ophoff, Roel A
AU  - Palmer, Cameron
AU  - Palotie, Aarno
AU  - Palviainen, Teemu
AU  - Pare, Guillaume
AU  - Paternoster, Lavinia
AU  - Peltonen, Leena
AU  - Penninx, Brenda W J H
AU  - Polasek, Ozren
AU  - Pramstaller, Peter P
AU  - Prokopenko, Inga
AU  - Raikkonen, Katri
AU  - Ripatti, Samuli
AU  - Rivadeneira, Fernando
AU  - Rudan, Igor
AU  - Rujescu, Dan
AU  - Smit, Johannes H
AU  - Smith, George Davey
AU  - Smoller, Jordan W
AU  - Soranzo, Nicole
AU  - Spector, Tim D
AU  - Pourcain, Beate St
AU  - Starr, John M
AU  - Stefánsson, Hreinn
AU  - Steinberg, Stacy
AU  - Teder-Laving, Maris
AU  - Thorleifsson, Gudmar
AU  - Stefánsson, Kári
AU  - Timpson, Nicholas J
AU  - Uitterlinden, André G
AU  - van Duijn, Cornelia M
AU  - van Rooij, Frank J A
AU  - Vink, Jaqueline M
AU  - Vollenweider, Peter
AU  - Vuoksimaa, Eero
AU  - Waeber, Gérard
AU  - Wareham, Nicholas J
AU  - Warrington, Nicole
AU  - Waterworth, Dawn
AU  - Werge, Thomas
AU  - Wichmann, H-Erich
AU  - Widen, Elisabeth
AU  - Willemsen, Gonneke
AU  - Wright, Alan F
AU  - Wright, Margaret J
AU  - Xu, Mousheng
AU  - Zhao, Jing Hua
AU  - Kraft, Peter
AU  - Hinds, David A
AU  - Lindgren, Cecilia M
AU  - Mägi, Reedik
AU  - Neale, Benjamin M
AU  - Evans, David M
AU  - Medland, Sarah E
TI  - Genome-wide association study identifies 48 common genetic variants associated with handedness.
JO  - Nature human behaviour
VL  - 5
IS  - 1
SN  - 2397-3374
CY  - London
PB  - Nature Research
M1  - DZNE-2021-00872
SP  - 59 - 70
PY  - 2021
AB  - Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
KW  - Adult
KW  - Aged
KW  - Female
KW  - Functional Laterality: genetics
KW  - Gene Frequency: genetics
KW  - Genetic Loci: genetics
KW  - Genetic Variation: genetics
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Linkage Disequilibrium
KW  - Male
KW  - Middle Aged
KW  - Polymorphism, Single Nucleotide: genetics
KW  - Quantitative Trait, Heritable
KW  - Sex Factors
LB  - PUB:(DE-HGF)16
C6  - pmid:32989287
C2  - pmc:PMC7116623
DO  - DOI:10.1038/s41562-020-00956-y
UR  - https://pub.dzne.de/record/155704
ER  -