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@ARTICLE{CuellarPartida:155704,
      author       = {Cuellar-Partida, Gabriel and Tung, Joyce Y and Eriksson,
                      Nicholas and Albrecht, Eva and Aliev, Fazil and Andreassen,
                      Ole A and Barroso, Inês and Beckmann, Jacques S and Boks,
                      Marco P and Boomsma, Dorret I and Boyd, Heather A and
                      Breteler, Monique and Campbell, Harry and Chasman, Daniel I
                      and Cherkas, Lynn F and Davies, Gail and de Geus, Eco J C
                      and Deary, Ian J and Deloukas, Panos and Dick, Danielle M
                      and Duffy, David L and Eriksson, Johan G and Esko, Tõnu and
                      Feenstra, Bjarke and Geller, Frank and Gieger, Christian and
                      Giegling, Ina and Gordon, Scott D and Han, Jiali and Hansen,
                      Thomas F and Hartmann, Annette M and Hayward, Caroline and
                      Heikkilä, Kauko and Hicks, Andrew A and Hirschhorn, Joel N
                      and Hottenga, Jouke-Jan and Huffman, Jennifer E and Hwang,
                      Liang-Dar and Ikram, M Arfan and Kaprio, Jaakko and Kemp,
                      John P and Khaw, Kay-Tee and Klopp, Norman and Konte,
                      Bettina and Kutalik, Zoltan and Lahti, Jari and Li, Xin and
                      Loos, Ruth J F and Luciano, Michelle and Magnusson, Sigurdur
                      H and Mangino, Massimo and Marques-Vidal, Pedro and Martin,
                      Nicholas G and McArdle, Wendy L and McCarthy, Mark I and
                      Medina-Gomez, Carolina and Melbye, Mads and Melville, Scott
                      A and Metspalu, Andres and Milani, Lili and Mooser, Vincent
                      and Nelis, Mari and Nyholt, Dale R and O'Connell, Kevin S
                      and Ophoff, Roel A and Palmer, Cameron and Palotie, Aarno
                      and Palviainen, Teemu and Pare, Guillaume and Paternoster,
                      Lavinia and Peltonen, Leena and Penninx, Brenda W J H and
                      Polasek, Ozren and Pramstaller, Peter P and Prokopenko, Inga
                      and Raikkonen, Katri and Ripatti, Samuli and Rivadeneira,
                      Fernando and Rudan, Igor and Rujescu, Dan and Smit, Johannes
                      H and Smith, George Davey and Smoller, Jordan W and Soranzo,
                      Nicole and Spector, Tim D and Pourcain, Beate St and Starr,
                      John M and Stefánsson, Hreinn and Steinberg, Stacy and
                      Teder-Laving, Maris and Thorleifsson, Gudmar and
                      Stefánsson, Kári and Timpson, Nicholas J and Uitterlinden,
                      André G and van Duijn, Cornelia M and van Rooij, Frank J A
                      and Vink, Jaqueline M and Vollenweider, Peter and Vuoksimaa,
                      Eero and Waeber, Gérard and Wareham, Nicholas J and
                      Warrington, Nicole and Waterworth, Dawn and Werge, Thomas
                      and Wichmann, H-Erich and Widen, Elisabeth and Willemsen,
                      Gonneke and Wright, Alan F and Wright, Margaret J and Xu,
                      Mousheng and Zhao, Jing Hua and Kraft, Peter and Hinds,
                      David A and Lindgren, Cecilia M and Mägi, Reedik and Neale,
                      Benjamin M and Evans, David M and Medland, Sarah E},
      title        = {{G}enome-wide association study identifies 48 common
                      genetic variants associated with handedness.},
      journal      = {Nature human behaviour},
      volume       = {5},
      number       = {1},
      issn         = {2397-3374},
      address      = {London},
      publisher    = {Nature Research},
      reportid     = {DZNE-2021-00872},
      pages        = {59 - 70},
      year         = {2021},
      abstract     = {Handedness has been extensively studied because of its
                      relationship with language and the over-representation of
                      left-handers in some neurodevelopmental disorders. Using
                      data from the UK Biobank, 23andMe and the International
                      Handedness Consortium, we conducted a genome-wide
                      association meta-analysis of handedness (N = 1,766,671). We
                      found 41 loci associated (P < 5 × 10-8) with
                      left-handedness and 7 associated with ambidexterity.
                      Tissue-enrichment analysis implicated the CNS in the
                      aetiology of handedness. Pathways including regulation of
                      microtubules and brain morphology were also highlighted. We
                      found suggestive positive genetic correlations between
                      left-handedness and neuropsychiatric traits, including
                      schizophrenia and bipolar disorder. Furthermore, the genetic
                      correlation between left-handedness and ambidexterity is low
                      (rG = 0.26), which implies that these traits are largely
                      influenced by different genetic mechanisms. Our findings
                      suggest that handedness is highly polygenic and that the
                      genetic variants that predispose to left-handedness may
                      underlie part of the association with some psychiatric
                      disorders.},
      keywords     = {Adult / Aged / Female / Functional Laterality: genetics /
                      Gene Frequency: genetics / Genetic Loci: genetics / Genetic
                      Variation: genetics / Genome-Wide Association Study / Humans
                      / Linkage Disequilibrium / Male / Middle Aged /
                      Polymorphism, Single Nucleotide: genetics / Quantitative
                      Trait, Heritable / Sex Factors},
      cin          = {AG Breteler 1},
      ddc          = {150},
      cid          = {I:(DE-2719)1012001},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32989287},
      pmc          = {pmc:PMC7116623},
      doi          = {10.1038/s41562-020-00956-y},
      url          = {https://pub.dzne.de/record/155704},
}