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| Home > Publications Database > Genome-wide association study identifies 48 common genetic variants associated with handedness. > print |
| 001 | 155704 | ||
| 005 | 20230915092338.0 | ||
| 024 | 7 | _ | |a 10.1038/s41562-020-00956-y |2 doi |
| 024 | 7 | _ | |a pmid:32989287 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC7116623 |2 pmc |
| 024 | 7 | _ | |a altmetric:91352703 |2 altmetric |
| 037 | _ | _ | |a DZNE-2021-00872 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 150 |
| 100 | 1 | _ | |a Cuellar-Partida, Gabriel |0 0000-0001-7648-4097 |b 0 |
| 245 | _ | _ | |a Genome-wide association study identifies 48 common genetic variants associated with handedness. |
| 260 | _ | _ | |a London |c 2021 |b Nature Research |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1630583803_2003 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Functional Laterality: genetics |2 MeSH |
| 650 | _ | 2 | |a Gene Frequency: genetics |2 MeSH |
| 650 | _ | 2 | |a Genetic Loci: genetics |2 MeSH |
| 650 | _ | 2 | |a Genetic Variation: genetics |2 MeSH |
| 650 | _ | 2 | |a Genome-Wide Association Study |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Linkage Disequilibrium |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Polymorphism, Single Nucleotide: genetics |2 MeSH |
| 650 | _ | 2 | |a Quantitative Trait, Heritable |2 MeSH |
| 650 | _ | 2 | |a Sex Factors |2 MeSH |
| 700 | 1 | _ | |a Tung, Joyce Y |b 1 |
| 700 | 1 | _ | |a Eriksson, Nicholas |b 2 |
| 700 | 1 | _ | |a Albrecht, Eva |b 3 |
| 700 | 1 | _ | |a Aliev, Fazil |0 0000-0001-8357-4699 |b 4 |
| 700 | 1 | _ | |a Andreassen, Ole A |0 P:(DE-2719)9001146 |b 5 |u dzne |
| 700 | 1 | _ | |a Barroso, Inês |0 0000-0001-5800-4520 |b 6 |
| 700 | 1 | _ | |a Beckmann, Jacques S |0 0000-0002-9741-1900 |b 7 |
| 700 | 1 | _ | |a Boks, Marco P |0 0000-0001-6163-7484 |b 8 |
| 700 | 1 | _ | |a Boomsma, Dorret I |0 0000-0002-7099-7972 |b 9 |
| 700 | 1 | _ | |a Boyd, Heather A |0 0000-0001-6849-9985 |b 10 |
| 700 | 1 | _ | |a Breteler, Monique |0 P:(DE-2719)2810403 |b 11 |u dzne |
| 700 | 1 | _ | |a Campbell, Harry |b 12 |
| 700 | 1 | _ | |a Chasman, Daniel I |0 0000-0003-3357-0862 |b 13 |
| 700 | 1 | _ | |a Cherkas, Lynn F |b 14 |
| 700 | 1 | _ | |a Davies, Gail |b 15 |
| 700 | 1 | _ | |a de Geus, Eco J C |0 0000-0001-6022-2666 |b 16 |
| 700 | 1 | _ | |a Deary, Ian J |0 0000-0002-1733-263X |b 17 |
| 700 | 1 | _ | |a Deloukas, Panos |0 0000-0001-9251-070X |b 18 |
| 700 | 1 | _ | |a Dick, Danielle M |0 0000-0002-1636-893X |b 19 |
| 700 | 1 | _ | |a Duffy, David L |b 20 |
| 700 | 1 | _ | |a Eriksson, Johan G |b 21 |
| 700 | 1 | _ | |a Esko, Tõnu |b 22 |
| 700 | 1 | _ | |a Feenstra, Bjarke |0 0000-0003-1478-649X |b 23 |
| 700 | 1 | _ | |a Geller, Frank |0 0000-0002-9238-3269 |b 24 |
| 700 | 1 | _ | |a Gieger, Christian |b 25 |
| 700 | 1 | _ | |a Giegling, Ina |b 26 |
| 700 | 1 | _ | |a Gordon, Scott D |0 0000-0001-7623-328X |b 27 |
| 700 | 1 | _ | |a Han, Jiali |b 28 |
| 700 | 1 | _ | |a Hansen, Thomas F |0 0000-0001-6703-7762 |b 29 |
| 700 | 1 | _ | |a Hartmann, Annette M |b 30 |
| 700 | 1 | _ | |a Hayward, Caroline |0 0000-0002-9405-9550 |b 31 |
| 700 | 1 | _ | |a Heikkilä, Kauko |b 32 |
| 700 | 1 | _ | |a Hicks, Andrew A |0 0000-0001-6320-0411 |b 33 |
| 700 | 1 | _ | |a Hirschhorn, Joel N |0 0000-0002-1650-7901 |b 34 |
| 700 | 1 | _ | |a Hottenga, Jouke-Jan |0 0000-0002-5668-2368 |b 35 |
| 700 | 1 | _ | |a Huffman, Jennifer E |0 0000-0002-9672-2491 |b 36 |
| 700 | 1 | _ | |a Hwang, Liang-Dar |0 0000-0002-5535-2199 |b 37 |
| 700 | 1 | _ | |a Ikram, M Arfan |0 0000-0003-0372-8585 |b 38 |
| 700 | 1 | _ | |a Kaprio, Jaakko |0 0000-0002-3716-2455 |b 39 |
| 700 | 1 | _ | |a Kemp, John P |0 0000-0002-9105-2249 |b 40 |
| 700 | 1 | _ | |a Khaw, Kay-Tee |b 41 |
| 700 | 1 | _ | |a Klopp, Norman |b 42 |
| 700 | 1 | _ | |a Konte, Bettina |0 0000-0001-5287-308X |b 43 |
| 700 | 1 | _ | |a Kutalik, Zoltan |0 0000-0001-8285-7523 |b 44 |
| 700 | 1 | _ | |a Lahti, Jari |0 0000-0002-4310-5297 |b 45 |
| 700 | 1 | _ | |a Li, Xin |0 0000-0002-0135-8800 |b 46 |
| 700 | 1 | _ | |a Loos, Ruth J F |0 0000-0002-8532-5087 |b 47 |
| 700 | 1 | _ | |a Luciano, Michelle |0 0000-0002-7306-3008 |b 48 |
| 700 | 1 | _ | |a Magnusson, Sigurdur H |0 0000-0001-6669-3071 |b 49 |
| 700 | 1 | _ | |a Mangino, Massimo |0 0000-0002-2167-7470 |b 50 |
| 700 | 1 | _ | |a Marques-Vidal, Pedro |0 0000-0002-4548-8500 |b 51 |
| 700 | 1 | _ | |a Martin, Nicholas G |0 0000-0003-4069-8020 |b 52 |
| 700 | 1 | _ | |a McArdle, Wendy L |0 0000-0002-0605-5403 |b 53 |
| 700 | 1 | _ | |a McCarthy, Mark I |0 0000-0002-4393-0510 |b 54 |
| 700 | 1 | _ | |a Medina-Gomez, Carolina |0 0000-0001-7999-5538 |b 55 |
| 700 | 1 | _ | |a Melbye, Mads |0 0000-0001-8264-6785 |b 56 |
| 700 | 1 | _ | |a Melville, Scott A |b 57 |
| 700 | 1 | _ | |a Metspalu, Andres |0 0000-0002-3718-796X |b 58 |
| 700 | 1 | _ | |a Milani, Lili |0 0000-0002-5323-3102 |b 59 |
| 700 | 1 | _ | |a Mooser, Vincent |b 60 |
| 700 | 1 | _ | |a Nelis, Mari |0 0000-0001-9748-1020 |b 61 |
| 700 | 1 | _ | |a Nyholt, Dale R |0 0000-0001-7159-3040 |b 62 |
| 700 | 1 | _ | |a O'Connell, Kevin S |0 0000-0002-6865-8795 |b 63 |
| 700 | 1 | _ | |a Ophoff, Roel A |0 0000-0002-8287-6457 |b 64 |
| 700 | 1 | _ | |a Palmer, Cameron |b 65 |
| 700 | 1 | _ | |a Palotie, Aarno |b 66 |
| 700 | 1 | _ | |a Palviainen, Teemu |0 0000-0002-7847-8384 |b 67 |
| 700 | 1 | _ | |a Pare, Guillaume |0 0000-0002-6795-4760 |b 68 |
| 700 | 1 | _ | |a Paternoster, Lavinia |0 0000-0003-2514-0889 |b 69 |
| 700 | 1 | _ | |a Peltonen, Leena |b 70 |
| 700 | 1 | _ | |a Penninx, Brenda W J H |b 71 |
| 700 | 1 | _ | |a Polasek, Ozren |0 0000-0002-5765-1862 |b 72 |
| 700 | 1 | _ | |a Pramstaller, Peter P |b 73 |
| 700 | 1 | _ | |a Prokopenko, Inga |0 0000-0003-1624-7457 |b 74 |
| 700 | 1 | _ | |a Raikkonen, Katri |b 75 |
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| 700 | 1 | _ | |a Rivadeneira, Fernando |0 0000-0001-9435-9441 |b 77 |
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| 700 | 1 | _ | |a Rujescu, Dan |b 79 |
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| 700 | 1 | _ | |a Smith, George Davey |0 0000-0002-1407-8314 |b 81 |
| 700 | 1 | _ | |a Smoller, Jordan W |0 0000-0002-0381-6334 |b 82 |
| 700 | 1 | _ | |a Soranzo, Nicole |b 83 |
| 700 | 1 | _ | |a Spector, Tim D |0 0000-0002-9795-0365 |b 84 |
| 700 | 1 | _ | |a Pourcain, Beate St |0 0000-0002-4680-3517 |b 85 |
| 700 | 1 | _ | |a Starr, John M |b 86 |
| 700 | 1 | _ | |a Stefánsson, Hreinn |0 0000-0002-9331-6666 |b 87 |
| 700 | 1 | _ | |a Steinberg, Stacy |0 0000-0001-7726-5152 |b 88 |
| 700 | 1 | _ | |a Teder-Laving, Maris |0 0000-0002-5872-1850 |b 89 |
| 700 | 1 | _ | |a Thorleifsson, Gudmar |b 90 |
| 700 | 1 | _ | |a Stefánsson, Kári |0 0000-0003-1676-864X |b 91 |
| 700 | 1 | _ | |a Timpson, Nicholas J |0 0000-0002-7141-9189 |b 92 |
| 700 | 1 | _ | |a Uitterlinden, André G |0 0000-0002-7276-3387 |b 93 |
| 700 | 1 | _ | |a van Duijn, Cornelia M |b 94 |
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| 700 | 1 | _ | |a Vink, Jaqueline M |0 0000-0003-3910-3528 |b 96 |
| 700 | 1 | _ | |a Vollenweider, Peter |b 97 |
| 700 | 1 | _ | |a Vuoksimaa, Eero |b 98 |
| 700 | 1 | _ | |a Waeber, Gérard |0 0000-0003-4193-788X |b 99 |
| 700 | 1 | _ | |a Wareham, Nicholas J |b 100 |
| 700 | 1 | _ | |a Warrington, Nicole |0 0000-0003-4195-775X |b 101 |
| 700 | 1 | _ | |a Waterworth, Dawn |b 102 |
| 700 | 1 | _ | |a Werge, Thomas |0 0000-0003-1829-0766 |b 103 |
| 700 | 1 | _ | |a Wichmann, H-Erich |b 104 |
| 700 | 1 | _ | |a Widen, Elisabeth |b 105 |
| 700 | 1 | _ | |a Willemsen, Gonneke |b 106 |
| 700 | 1 | _ | |a Wright, Alan F |b 107 |
| 700 | 1 | _ | |a Wright, Margaret J |0 0000-0001-7133-4970 |b 108 |
| 700 | 1 | _ | |a Xu, Mousheng |b 109 |
| 700 | 1 | _ | |a Zhao, Jing Hua |0 0000-0002-1463-5870 |b 110 |
| 700 | 1 | _ | |a Kraft, Peter |0 0000-0002-4472-8103 |b 111 |
| 700 | 1 | _ | |a Hinds, David A |0 0000-0002-4911-803X |b 112 |
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| 700 | 1 | _ | |a Evans, David M |0 0000-0003-0663-4621 |b 116 |
| 700 | 1 | _ | |a Medland, Sarah E |0 0000-0003-1382-380X |b 117 |e Corresponding author |
| 773 | _ | _ | |a 10.1038/s41562-020-00956-y |g Vol. 5, no. 1, p. 59 - 70 |0 PERI:(DE-600)2885046-4 |n 1 |p 59 - 70 |t Nature human behaviour |v 5 |y 2021 |x 2397-3374 |
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