TY  - JOUR
AU  - Fiorilli, Julien
AU  - Bos, Jeroen J
AU  - Grande, Xenia
AU  - Lim, Judith
AU  - Düzel, Emrah
AU  - Pennartz, Cyriel M A
TI  - Reconciling the object and spatial processing views of the perirhinal cortex through task-relevant unitization.
JO  - Hippocampus
VL  - 31
IS  - 7
SN  - 1098-1063
CY  - New York, NY [u.a.]
PB  - Wiley
M1  - DZNE-2021-00902
SP  - 737 - 755
PY  - 2021
AB  - The perirhinal cortex is situated on the border between sensory association cortex and the hippocampal formation. It serves an important function as a transition area between the sensory neocortex and the medial temporal lobe. While the perirhinal cortex has traditionally been associated with object coding and the 'what' pathway of the temporal lobe, current evidence suggests a broader function of the perirhinal cortex in solving feature ambiguity and processing complex stimuli. Besides fulfilling functions in object coding, recent neurophysiological findings in freely moving rodents indicate that the perirhinal cortex also contributes to spatial and contextual processing beyond individual sensory modalities. Here, we address how these two opposing views on perirhinal cortex-the object-centered and spatial-contextual processing hypotheses-may be reconciled. The perirhinal cortex is consistently recruited when different features can be merged perceptually or conceptually into a single entity. Features that are unitized in these entities include object information from multiple sensory domains, reward associations, semantic features and spatial/contextual associations. We propose that the same perirhinal network circuits can be flexibly deployed for multiple cognitive functions, such that the perirhinal cortex performs similar unitization operations on different types of information, depending on behavioral demands and ranging from the object-related domain to spatial, contextual and semantic information.
KW  - Cerebral Cortex
KW  - Cognition
KW  - Hippocampus: physiology
KW  - Perirhinal Cortex
KW  - Spatial Processing
KW  - contextual processing (Other)
KW  - hippocampus (Other)
KW  - multisensory integration (Other)
KW  - perirhinal cortex (Other)
KW  - spatial coding (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33523577
C2  - pmc:PMC8359385
DO  - DOI:10.1002/hipo.23304
UR  - https://pub.dzne.de/record/155734
ER  -