Journal Article (Review Article)

DZNE-2021-00902

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reconciling the object and spatial processing views of the perirhinal cortex through task-relevant unitization.

Fiorilli, J. ; Bos, J. J. ; Grande, X.DZNE* ; Lim, J. ; Düzel, E.DZNE* ; Pennartz, C. M. A.

2021
Wiley New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1002/hipo.23304

Abstract: The perirhinal cortex is situated on the border between sensory association cortex and the hippocampal formation. It serves an important function as a transition area between the sensory neocortex and the medial temporal lobe. While the perirhinal cortex has traditionally been associated with object coding and the 'what' pathway of the temporal lobe, current evidence suggests a broader function of the perirhinal cortex in solving feature ambiguity and processing complex stimuli. Besides fulfilling functions in object coding, recent neurophysiological findings in freely moving rodents indicate that the perirhinal cortex also contributes to spatial and contextual processing beyond individual sensory modalities. Here, we address how these two opposing views on perirhinal cortex-the object-centered and spatial-contextual processing hypotheses-may be reconciled. The perirhinal cortex is consistently recruited when different features can be merged perceptually or conceptually into a single entity. Features that are unitized in these entities include object information from multiple sensory domains, reward associations, semantic features and spatial/contextual associations. We propose that the same perirhinal network circuits can be flexibly deployed for multiple cognitive functions, such that the perirhinal cortex performs similar unitization operations on different types of information, depending on behavioral demands and ranging from the object-related domain to spatial, contextual and semantic information.

Keyword(s): Cerebral Cortex (MeSH) ; Cognition (MeSH) ; Hippocampus: physiology (MeSH) ; Perirhinal Cortex (MeSH) ; Spatial Processing (MeSH) ; contextual processing ; hippocampus ; multisensory integration ; perirhinal cortex ; spatial coding

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Contributing Institute(s):

1. Linking Imaging Projects (AG Speck)
2. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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