%0 Journal Article
%A Chia, Ruth
%A Sabir, Marya S
%A Bandres-Ciga, Sara
%A Saez-Atienzar, Sara
%A Reynolds, Regina H
%A Gustavsson, Emil
%A Walton, Ronald L
%A Ahmed, Sarah
%A Viollet, Coralie
%A Ding, Jinhui
%A Makarious, Mary B
%A Diez-Fairen, Monica
%A Portley, Makayla K
%A Shah, Zalak
%A Abramzon, Yevgeniya
%A Hernandez, Dena Michelle Godwin
%A Blauwendraat, Cornelis
%A Stone, David J
%A Eicher, John
%A Parkkinen, Laura
%A Ansorge, Olaf
%A Clark, Lorraine
%A Honig, Lawrence S
%A Marder, Karen
%A Lemstra, Afina
%A St George-Hyslop, Peter
%A Londos, Elisabet
%A Morgan, Kevin
%A Lashley, Tammaryn
%A Warner, Thomas T
%A Jaunmuktane, Zane
%A Galasko, Douglas
%A Santana, Isabel
%A Tienari, Pentti J
%A Myllykangas, Liisa
%A Oinas, Minna
%A Cairns, Nigel J
%A Morris, John C
%A Halliday, Glenda M
%A Van Deerlin, Vivianna M
%A Trojanowski, John Q
%A Grassano, Maurizio
%A Calvo, Andrea
%A Mora, Gabriele
%A Canosa, Antonio
%A Floris, Gianluca
%A Bohannan, Ryan C
%A Brett, Francesca
%A Gan-Or, Ziv
%A Geiger, Joshua T
%A Moore, Anni
%A May, Patrick
%A Krüger, Rejko
%A Goldstein, David S
%A Lopez, Grisel
%A Tayebi, Nahid
%A Sidransky, Ellen
%A Norcliffe-Kaufmann, Lucy
%A Palma, Jose-Alberto
%A Kaufmann, Horacio
%A Shakkottai, Vikram G
%A Perkins, Matthew
%A Newell, Kathy L
%A Gasser, Thomas
%A Schulte, Claudia
%A Landi, Francesco
%A Salvi, Erika
%A Cusi, Daniele
%A Masliah, Eliezer
%A Kim, Ronald C
%A Caraway, Chad A
%A Monuki, Edwin S
%A Brunetti, Maura
%A Dawson, Ted M
%A Rosenthal, Liana S
%A Albert, Marilyn S
%A Pletnikova, Olga
%A Troncoso, Juan C
%A Flanagan, Margaret E
%A Mao, Qinwen
%A Bigio, Eileen H
%A Rodríguez-Rodríguez, Eloy
%A Infante, Jon
%A Lage, Carmen
%A González-Aramburu, Isabel
%A Sanchez-Juan, Pascual
%A Ghetti, Bernardino
%A Keith, Julia
%A Black, Sandra E
%A Masellis, Mario
%A Rogaeva, Ekaterina
%A Duyckaerts, Charles
%A Brice, Alexis
%A Lesage, Suzanne
%A Xiromerisiou, Georgia
%A Barrett, Matthew J
%A Tilley, Bension S
%A Gentleman, Steve
%A Logroscino, Giancarlo
%A Serrano, Geidy E
%A Beach, Thomas G
%A McKeith, Ian G
%A Thomas, Alan J
%A Attems, Johannes
%A Morris, Christopher M
%A Palmer, Laura
%A Love, Seth
%A Troakes, Claire
%A Al-Sarraj, Safa
%A Hodges, Angela K
%A Aarsland, Dag
%A Klein, Gregory
%A Kaiser, Scott M
%A Woltjer, Randy
%A Pastor, Pau
%A Bekris, Lynn M
%A Leverenz, James B
%A Besser, Lilah M
%A Kuzma, Amanda
%A Renton, Alan E
%A Goate, Alison
%A Bennett, David A
%A Scherzer, Clemens R
%A Morris, Huw R
%A Ferrari, Raffaele
%A Albani, Diego
%A Pickering-Brown, Stuart
%A Faber, Kelley
%A Kukull, Walter A
%A Morenas-Rodriguez, Estrella
%A Lleó, Alberto
%A Fortea, Juan
%A Alcolea, Daniel
%A Clarimon, Jordi
%A Nalls, Mike A
%A Ferrucci, Luigi
%A Resnick, Susan M
%A Tanaka, Toshiko
%A Foroud, Tatiana M
%A Graff-Radford, Neill R
%A Wszolek, Zbigniew K
%A Ferman, Tanis
%A Boeve, Bradley F
%A Hardy, John A
%A Topol, Eric J
%A Torkamani, Ali
%A Singleton, Andrew B
%A Ryten, Mina
%A Dickson, Dennis W
%A Chiò, Adriano
%A Ross, Owen A
%A Gibbs, J Raphael
%A Dalgard, Clifton L
%A Traynor, Bryan J
%A Scholz, Sonja W
%A Sotis, Anthony R
%A Sukumar, Gauthaman
%A Alba, Camille
%A Lott, Nathaniel
%A Martinez, Elisa McGrath
%A Tuck, Meila
%A Singh, Jatinder
%A Bacikova, Dagmar
%A Zhang, Xijun
%A Hupalo, Daniel N
%A Adeleye, Adelani
%A Wilkerson, Matthew D
%A Pollard, Harvey B
%T Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.
%J Nature genetics
%V 53
%N 3
%@ 1546-1718
%C London
%I Macmillan Publishers Limited, part of Springer Nature
%M DZNE-2021-01145
%P 294 - 303
%D 2021
%X The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer's disease and Parkinson's disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition.
%K Adaptor Proteins, Signal Transducing: genetics
%K Alzheimer Disease: genetics
%K Case-Control Studies
%K Gene Expression Profiling
%K Genetic Predisposition to Disease
%K Genome, Human
%K Genome-Wide Association Study
%K Glucosylceramidase: genetics
%K Humans
%K Lewy Body Disease: genetics
%K Nuclear Proteins: genetics
%K Parkinson Disease: genetics
%K Polymorphism, Single Nucleotide
%K Tumor Suppressor Proteins: genetics
%K alpha-Synuclein: genetics
%K Adaptor Proteins, Signal Transducing (NLM Chemicals)
%K BIN1 protein, human (NLM Chemicals)
%K Nuclear Proteins (NLM Chemicals)
%K SNCA protein, human (NLM Chemicals)
%K Tumor Suppressor Proteins (NLM Chemicals)
%K alpha-Synuclein (NLM Chemicals)
%K GBA protein, human (NLM Chemicals)
%K Glucosylceramidase (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33589841
%2 pmc:PMC7946812
%R 10.1038/s41588-021-00785-3
%U https://pub.dzne.de/record/156013