guest ::
| Home > Publications Database > Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. > print |
| Home > Publications Database > Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. > print |
| 001 | 156013 | ||
| 005 | 20250414104610.0 | ||
| 024 | 7 | _ | |a 10.1038/s41588-021-00785-3 |2 doi |
| 024 | 7 | _ | |a pmid:33589841 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC7946812 |2 pmc |
| 024 | 7 | _ | |a 1061-4036 |2 ISSN |
| 024 | 7 | _ | |a 1546-1718 |2 ISSN |
| 024 | 7 | _ | |a altmetric:100201763 |2 altmetric |
| 037 | _ | _ | |a DZNE-2021-01145 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Chia, Ruth |b 0 |
| 245 | _ | _ | |a Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. |
| 260 | _ | _ | |a London |c 2021 |b Macmillan Publishers Limited, part of Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1744620294_16032 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer's disease and Parkinson's disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Adaptor Proteins, Signal Transducing |2 NLM Chemicals |
| 650 | _ | 7 | |a BIN1 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Nuclear Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a SNCA protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Tumor Suppressor Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a alpha-Synuclein |2 NLM Chemicals |
| 650 | _ | 7 | |a GBA protein, human |0 EC 3.2.1.45 |2 NLM Chemicals |
| 650 | _ | 7 | |a Glucosylceramidase |0 EC 3.2.1.45 |2 NLM Chemicals |
| 650 | _ | 2 | |a Adaptor Proteins, Signal Transducing: genetics |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: genetics |2 MeSH |
| 650 | _ | 2 | |a Case-Control Studies |2 MeSH |
| 650 | _ | 2 | |a Gene Expression Profiling |2 MeSH |
| 650 | _ | 2 | |a Genetic Predisposition to Disease |2 MeSH |
| 650 | _ | 2 | |a Genome, Human |2 MeSH |
| 650 | _ | 2 | |a Genome-Wide Association Study |2 MeSH |
| 650 | _ | 2 | |a Glucosylceramidase: genetics |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Lewy Body Disease: genetics |2 MeSH |
| 650 | _ | 2 | |a Nuclear Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Parkinson Disease: genetics |2 MeSH |
| 650 | _ | 2 | |a Polymorphism, Single Nucleotide |2 MeSH |
| 650 | _ | 2 | |a Tumor Suppressor Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a alpha-Synuclein: genetics |2 MeSH |
| 700 | 1 | _ | |a Sabir, Marya S |b 1 |
| 700 | 1 | _ | |a Bandres-Ciga, Sara |b 2 |
| 700 | 1 | _ | |a Saez-Atienzar, Sara |b 3 |
| 700 | 1 | _ | |a Reynolds, Regina H |0 0000-0001-6470-7919 |b 4 |
| 700 | 1 | _ | |a Gustavsson, Emil |0 0000-0003-0541-7537 |b 5 |
| 700 | 1 | _ | |a Walton, Ronald L |b 6 |
| 700 | 1 | _ | |a Ahmed, Sarah |b 7 |
| 700 | 1 | _ | |a Viollet, Coralie |b 8 |
| 700 | 1 | _ | |a Ding, Jinhui |b 9 |
| 700 | 1 | _ | |a Makarious, Mary B |b 10 |
| 700 | 1 | _ | |a Diez-Fairen, Monica |0 0000-0003-1882-0309 |b 11 |
| 700 | 1 | _ | |a Portley, Makayla K |0 0000-0003-2866-9198 |b 12 |
| 700 | 1 | _ | |a Shah, Zalak |b 13 |
| 700 | 1 | _ | |a Abramzon, Yevgeniya |b 14 |
| 700 | 1 | _ | |a Hernandez, Dena Michelle Godwin |0 P:(DE-2719)2812102 |b 15 |u dzne |
| 700 | 1 | _ | |a Blauwendraat, Cornelis |0 P:(DE-2719)2810837 |b 16 |u dzne |
| 700 | 1 | _ | |a Stone, David J |b 17 |
| 700 | 1 | _ | |a Eicher, John |b 18 |
| 700 | 1 | _ | |a Parkkinen, Laura |0 0000-0002-3392-8564 |b 19 |
| 700 | 1 | _ | |a Ansorge, Olaf |b 20 |
| 700 | 1 | _ | |a Clark, Lorraine |b 21 |
| 700 | 1 | _ | |a Honig, Lawrence S |b 22 |
| 700 | 1 | _ | |a Marder, Karen |b 23 |
| 700 | 1 | _ | |a Lemstra, Afina |b 24 |
| 700 | 1 | _ | |a St George-Hyslop, Peter |0 0000-0003-0796-7209 |b 25 |
| 700 | 1 | _ | |a Londos, Elisabet |b 26 |
| 700 | 1 | _ | |a Morgan, Kevin |0 0000-0002-8217-2396 |b 27 |
| 700 | 1 | _ | |a Lashley, Tammaryn |b 28 |
| 700 | 1 | _ | |a Warner, Thomas T |b 29 |
| 700 | 1 | _ | |a Jaunmuktane, Zane |b 30 |
| 700 | 1 | _ | |a Galasko, Douglas |b 31 |
| 700 | 1 | _ | |a Santana, Isabel |b 32 |
| 700 | 1 | _ | |a Tienari, Pentti J |0 0000-0001-5686-2900 |b 33 |
| 700 | 1 | _ | |a Myllykangas, Liisa |b 34 |
| 700 | 1 | _ | |a Oinas, Minna |0 0000-0002-6150-091X |b 35 |
| 700 | 1 | _ | |a Cairns, Nigel J |0 0000-0001-9858-3344 |b 36 |
| 700 | 1 | _ | |a Morris, John C |b 37 |
| 700 | 1 | _ | |a Halliday, Glenda M |0 0000-0003-0422-8398 |b 38 |
| 700 | 1 | _ | |a Van Deerlin, Vivianna M |0 0000-0002-7400-9097 |b 39 |
| 700 | 1 | _ | |a Trojanowski, John Q |0 P:(DE-2719)9000946 |b 40 |u dzne |
| 700 | 1 | _ | |a Grassano, Maurizio |b 41 |
| 700 | 1 | _ | |a Calvo, Andrea |0 0000-0002-5122-7243 |b 42 |
| 700 | 1 | _ | |a Mora, Gabriele |b 43 |
| 700 | 1 | _ | |a Canosa, Antonio |b 44 |
| 700 | 1 | _ | |a Floris, Gianluca |b 45 |
| 700 | 1 | _ | |a Bohannan, Ryan C |b 46 |
| 700 | 1 | _ | |a Brett, Francesca |b 47 |
| 700 | 1 | _ | |a Gan-Or, Ziv |0 0000-0003-0332-234X |b 48 |
| 700 | 1 | _ | |a Geiger, Joshua T |b 49 |
| 700 | 1 | _ | |a Moore, Anni |b 50 |
| 700 | 1 | _ | |a May, Patrick |0 0000-0001-8698-3770 |b 51 |
| 700 | 1 | _ | |a Krüger, Rejko |0 P:(DE-2719)2811170 |b 52 |u dzne |
| 700 | 1 | _ | |a Goldstein, David S |b 53 |
| 700 | 1 | _ | |a Lopez, Grisel |b 54 |
| 700 | 1 | _ | |a Tayebi, Nahid |0 0000-0002-1007-4957 |b 55 |
| 700 | 1 | _ | |a Sidransky, Ellen |b 56 |
| 700 | 1 | _ | |a Center, American Genome |b 57 |e Collaboration Author |
| 700 | 1 | _ | |a Norcliffe-Kaufmann, Lucy |b 58 |
| 700 | 1 | _ | |a Palma, Jose-Alberto |b 59 |
| 700 | 1 | _ | |a Kaufmann, Horacio |0 0000-0002-1851-9981 |b 60 |
| 700 | 1 | _ | |a Shakkottai, Vikram G |0 0000-0003-2742-6469 |b 61 |
| 700 | 1 | _ | |a Perkins, Matthew |0 0000-0001-7715-0638 |b 62 |
| 700 | 1 | _ | |a Newell, Kathy L |b 63 |
| 700 | 1 | _ | |a Gasser, Thomas |0 P:(DE-2719)2320009 |b 64 |u dzne |
| 700 | 1 | _ | |a Schulte, Claudia |0 P:(DE-2719)9000366 |b 65 |u dzne |
| 700 | 1 | _ | |a Landi, Francesco |b 66 |
| 700 | 1 | _ | |a Salvi, Erika |b 67 |
| 700 | 1 | _ | |a Cusi, Daniele |0 0000-0002-1006-7597 |b 68 |
| 700 | 1 | _ | |a Masliah, Eliezer |b 69 |
| 700 | 1 | _ | |a Kim, Ronald C |b 70 |
| 700 | 1 | _ | |a Caraway, Chad A |b 71 |
| 700 | 1 | _ | |a Monuki, Edwin S |b 72 |
| 700 | 1 | _ | |a Brunetti, Maura |b 73 |
| 700 | 1 | _ | |a Dawson, Ted M |b 74 |
| 700 | 1 | _ | |a Rosenthal, Liana S |b 75 |
| 700 | 1 | _ | |a Albert, Marilyn S |b 76 |
| 700 | 1 | _ | |a Pletnikova, Olga |b 77 |
| 700 | 1 | _ | |a Troncoso, Juan C |b 78 |
| 700 | 1 | _ | |a Flanagan, Margaret E |b 79 |
| 700 | 1 | _ | |a Mao, Qinwen |0 0000-0001-7876-2046 |b 80 |
| 700 | 1 | _ | |a Bigio, Eileen H |b 81 |
| 700 | 1 | _ | |a Rodríguez-Rodríguez, Eloy |0 0000-0001-7742-677X |b 82 |
| 700 | 1 | _ | |a Infante, Jon |b 83 |
| 700 | 1 | _ | |a Lage, Carmen |b 84 |
| 700 | 1 | _ | |a González-Aramburu, Isabel |b 85 |
| 700 | 1 | _ | |a Sanchez-Juan, Pascual |0 0000-0002-6081-8037 |b 86 |
| 700 | 1 | _ | |a Ghetti, Bernardino |b 87 |
| 700 | 1 | _ | |a Keith, Julia |b 88 |
| 700 | 1 | _ | |a Black, Sandra E |0 0000-0001-7093-8289 |b 89 |
| 700 | 1 | _ | |a Masellis, Mario |b 90 |
| 700 | 1 | _ | |a Rogaeva, Ekaterina |b 91 |
| 700 | 1 | _ | |a Duyckaerts, Charles |b 92 |
| 700 | 1 | _ | |a Brice, Alexis |b 93 |
| 700 | 1 | _ | |a Lesage, Suzanne |b 94 |
| 700 | 1 | _ | |a Xiromerisiou, Georgia |b 95 |
| 700 | 1 | _ | |a Barrett, Matthew J |b 96 |
| 700 | 1 | _ | |a Tilley, Bension S |b 97 |
| 700 | 1 | _ | |a Gentleman, Steve |b 98 |
| 700 | 1 | _ | |a Logroscino, Giancarlo |b 99 |
| 700 | 1 | _ | |a Serrano, Geidy E |b 100 |
| 700 | 1 | _ | |a Beach, Thomas G |b 101 |
| 700 | 1 | _ | |a McKeith, Ian G |b 102 |
| 700 | 1 | _ | |a Thomas, Alan J |b 103 |
| 700 | 1 | _ | |a Attems, Johannes |b 104 |
| 700 | 1 | _ | |a Morris, Christopher M |b 105 |
| 700 | 1 | _ | |a Palmer, Laura |b 106 |
| 700 | 1 | _ | |a Love, Seth |b 107 |
| 700 | 1 | _ | |a Troakes, Claire |0 0000-0002-1790-7376 |b 108 |
| 700 | 1 | _ | |a Al-Sarraj, Safa |b 109 |
| 700 | 1 | _ | |a Hodges, Angela K |0 0000-0002-5565-6678 |b 110 |
| 700 | 1 | _ | |a Aarsland, Dag |b 111 |
| 700 | 1 | _ | |a Klein, Gregory |b 112 |
| 700 | 1 | _ | |a Kaiser, Scott M |b 113 |
| 700 | 1 | _ | |a Woltjer, Randy |b 114 |
| 700 | 1 | _ | |a Pastor, Pau |0 0000-0002-7493-8777 |b 115 |
| 700 | 1 | _ | |a Bekris, Lynn M |b 116 |
| 700 | 1 | _ | |a Leverenz, James B |b 117 |
| 700 | 1 | _ | |a Besser, Lilah M |b 118 |
| 700 | 1 | _ | |a Kuzma, Amanda |b 119 |
| 700 | 1 | _ | |a Renton, Alan E |0 0000-0001-6702-8268 |b 120 |
| 700 | 1 | _ | |a Goate, Alison |0 0000-0002-0576-2472 |b 121 |
| 700 | 1 | _ | |a Bennett, David A |b 122 |
| 700 | 1 | _ | |a Scherzer, Clemens R |0 0000-0002-0567-9193 |b 123 |
| 700 | 1 | _ | |a Morris, Huw R |0 0000-0002-5473-3774 |b 124 |
| 700 | 1 | _ | |a Ferrari, Raffaele |b 125 |
| 700 | 1 | _ | |a Albani, Diego |0 0000-0002-7050-6723 |b 126 |
| 700 | 1 | _ | |a Pickering-Brown, Stuart |0 0000-0003-1561-6054 |b 127 |
| 700 | 1 | _ | |a Faber, Kelley |b 128 |
| 700 | 1 | _ | |a Kukull, Walter A |b 129 |
| 700 | 1 | _ | |a Morenas-Rodriguez, Estrella |0 P:(DE-2719)2812759 |b 130 |u dzne |
| 700 | 1 | _ | |a Lleó, Alberto |b 131 |
| 700 | 1 | _ | |a Fortea, Juan |b 132 |
| 700 | 1 | _ | |a Alcolea, Daniel |0 0000-0002-3819-3245 |b 133 |
| 700 | 1 | _ | |a Clarimon, Jordi |b 134 |
| 700 | 1 | _ | |a Nalls, Mike A |b 135 |
| 700 | 1 | _ | |a Ferrucci, Luigi |0 0000-0002-6273-1613 |b 136 |
| 700 | 1 | _ | |a Resnick, Susan M |b 137 |
| 700 | 1 | _ | |a Tanaka, Toshiko |b 138 |
| 700 | 1 | _ | |a Foroud, Tatiana M |0 0000-0002-5549-2212 |b 139 |
| 700 | 1 | _ | |a Graff-Radford, Neill R |b 140 |
| 700 | 1 | _ | |a Wszolek, Zbigniew K |b 141 |
| 700 | 1 | _ | |a Ferman, Tanis |b 142 |
| 700 | 1 | _ | |a Boeve, Bradley F |b 143 |
| 700 | 1 | _ | |a Hardy, John A |b 144 |
| 700 | 1 | _ | |a Topol, Eric J |0 0000-0002-1478-4729 |b 145 |
| 700 | 1 | _ | |a Torkamani, Ali |b 146 |
| 700 | 1 | _ | |a Singleton, Andrew B |b 147 |
| 700 | 1 | _ | |a Ryten, Mina |0 0000-0001-9520-6957 |b 148 |
| 700 | 1 | _ | |a Dickson, Dennis W |b 149 |
| 700 | 1 | _ | |a Chiò, Adriano |0 0000-0001-9579-5341 |b 150 |
| 700 | 1 | _ | |a Ross, Owen A |0 0000-0003-4813-756X |b 151 |
| 700 | 1 | _ | |a Gibbs, J Raphael |0 0000-0002-6985-0658 |b 152 |
| 700 | 1 | _ | |a Dalgard, Clifton L |b 153 |
| 700 | 1 | _ | |a Traynor, Bryan J |b 154 |
| 700 | 1 | _ | |a Scholz, Sonja W |0 0000-0002-6623-0429 |b 155 |
| 700 | 1 | _ | |a Sotis, Anthony R |b 156 |
| 700 | 1 | _ | |a Sukumar, Gauthaman |b 157 |
| 700 | 1 | _ | |a Alba, Camille |b 158 |
| 700 | 1 | _ | |a Lott, Nathaniel |b 159 |
| 700 | 1 | _ | |a Martinez, Elisa McGrath |b 160 |
| 700 | 1 | _ | |a Tuck, Meila |b 161 |
| 700 | 1 | _ | |a Singh, Jatinder |b 162 |
| 700 | 1 | _ | |a Bacikova, Dagmar |b 163 |
| 700 | 1 | _ | |a Zhang, Xijun |b 164 |
| 700 | 1 | _ | |a Hupalo, Daniel N |b 165 |
| 700 | 1 | _ | |a Adeleye, Adelani |b 166 |
| 700 | 1 | _ | |a Wilkerson, Matthew D |b 167 |
| 700 | 1 | _ | |a Pollard, Harvey B |b 168 |
| 773 | _ | _ | |a 10.1038/s41588-021-00785-3 |g Vol. 53, no. 3, p. 294 - 303 |0 PERI:(DE-600)1494946-5 |n 3 |p 294 - 303 |t Nature genetics |v 53 |y 2021 |x 1546-1718 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/156013/files/DZNE-2021-01145_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/156013/files/DZNE-2021-01145_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:156013 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 40 |6 P:(DE-2719)9000946 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 52 |6 P:(DE-2719)2811170 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 64 |6 P:(DE-2719)2320009 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 65 |6 P:(DE-2719)9000366 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 130 |6 P:(DE-2719)2812759 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-353 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-352 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Mechanisms |x 1 |
| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-28 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-01-28 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-28 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2022-11-09 |w ger |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NAT GENET : 2021 |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-09 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-09 |
| 915 | _ | _ | |a IF >= 40 |0 StatID:(DE-HGF)9940 |2 StatID |b NAT GENET : 2021 |d 2022-11-09 |
| 920 | 1 | _ | |0 I:(DE-2719)1110007 |k AG Haass |l Molecular Neurodegeneration |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)5000055 |k AG Berg |l Parkinson's Disease Genetics |x 1 |
| 920 | 1 | _ | |0 I:(DE-2719)1210000 |k AG Gasser |l Parkinson Genetics |x 2 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1110007 |
| 980 | _ | _ | |a I:(DE-2719)5000055 |
| 980 | _ | _ | |a I:(DE-2719)1210000 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|