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000157715 037__ $$aDZNE-2021-01172
000157715 041__ $$aEnglish
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000157715 1001_ $$0P:(DE-2719)2811643$$aIslam, Rezaul$$b0$$eFirst author
000157715 245__ $$aEpigenetic gene expression links heart failure to memory impairment.
000157715 260__ $$aHeidelberg$$bEMBO Press$$c2021
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000157715 520__ $$aIn current clinical practice, care of diseased patients is often restricted to separated disciplines. However, such an organ-centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients. Moreover, these patients have an increased risk for age-associated dementias. The underlying molecular mechanisms are presently unknown, and thus, corresponding therapeutic strategies to improve cognition in heart failure patients are missing. Using mice as model organisms, we show that heart failure leads to specific changes in hippocampal gene expression, a brain region intimately linked to cognition. These changes reflect increased cellular stress pathways which eventually lead to loss of neuronal euchromatin and reduced expression of a hippocampal gene cluster essential for cognition. Consequently, mice suffering from heart failure exhibit impaired memory function. These pathological changes are ameliorated via the administration of a drug that promotes neuronal euchromatin formation. Our study provides first insight to the molecular processes by which heart failure contributes to neuronal dysfunction and point to novel therapeutic avenues to treat cognitive defects in heart failure patients.
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000157715 650_7 $$2Other$$acognition
000157715 650_7 $$2Other$$aepigenetics
000157715 650_7 $$2Other$$aheart failure
000157715 650_7 $$2Other$$ahistone
000157715 650_7 $$2Other$$amemory impairment
000157715 650_2 $$2MeSH$$aAnimals
000157715 650_2 $$2MeSH$$aCognition
000157715 650_2 $$2MeSH$$aEpigenesis, Genetic
000157715 650_2 $$2MeSH$$aGene Expression
000157715 650_2 $$2MeSH$$aHeart Failure: genetics
000157715 650_2 $$2MeSH$$aHumans
000157715 650_2 $$2MeSH$$aMemory Disorders
000157715 650_2 $$2MeSH$$aMice
000157715 7001_ $$aLbik, Dawid$$b1
000157715 7001_ $$0P:(DE-2719)2812054$$aSakib, M Sadman$$b2
000157715 7001_ $$aMaximilian Hofmann, Raoul$$b3
000157715 7001_ $$0P:(DE-2719)2811247$$aBerulava, Tea$$b4
000157715 7001_ $$0P:(DE-2719)9002263$$aJiménez Mausbach, Martí$$b5$$udzne
000157715 7001_ $$0P:(DE-2719)9002258$$aCha, Julia$$b6$$udzne
000157715 7001_ $$0P:(DE-2719)9001958$$aGoldberg, Maria$$b7
000157715 7001_ $$0P:(DE-2719)2811844$$aElerdashvili, Vakhtang$$b8
000157715 7001_ $$0P:(DE-2719)9002272$$aSchiffmann, Christian$$b9$$udzne
000157715 7001_ $$aZieseniss, Anke$$b10
000157715 7001_ $$00000-0003-4630-9081$$aKatschinski, Dörthe Magdalena$$b11
000157715 7001_ $$0P:(DE-2719)2811099$$aSananbenesi, Farahnaz$$b12
000157715 7001_ $$0P:(DE-2719)9000440$$aToischer, Karl$$b13
000157715 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b14$$eLast author
000157715 773__ $$0PERI:(DE-600)2485479-7$$a10.15252/emmm.201911900$$gVol. 13, no. 3$$n3$$pe11900$$tEMBO molecular medicine$$v13$$x1757-4684$$y2021
000157715 8564_ $$uhttps://www.embopress.org/doi/full/10.15252/emmm.201911900
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