Journal Article

DZNE-2021-01172

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Epigenetic gene expression links heart failure to memory impairment.

Islam, R. (First author)DZNE* ; Lbik, D. ; Sakib, M. S.DZNE* ; Maximilian Hofmann, R. ; Berulava, T.DZNE* ; Jiménez Mausbach, M.DZNE* ; Cha, J.DZNE* ; Goldberg, M.DZNE* ; Elerdashvili, V.DZNE* ; Schiffmann, C.DZNE* ; Zieseniss, A. ; Katschinski, D. M. ; Sananbenesi, F.DZNE* ; Toischer, K.Extern* ; Fischer, A. (Last author)DZNE*

2021
EMBO Press Heidelberg

This record in other databases:    

Please use a persistent id in citations: doi:10.15252/emmm.201911900

Abstract: In current clinical practice, care of diseased patients is often restricted to separated disciplines. However, such an organ-centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients. Moreover, these patients have an increased risk for age-associated dementias. The underlying molecular mechanisms are presently unknown, and thus, corresponding therapeutic strategies to improve cognition in heart failure patients are missing. Using mice as model organisms, we show that heart failure leads to specific changes in hippocampal gene expression, a brain region intimately linked to cognition. These changes reflect increased cellular stress pathways which eventually lead to loss of neuronal euchromatin and reduced expression of a hippocampal gene cluster essential for cognition. Consequently, mice suffering from heart failure exhibit impaired memory function. These pathological changes are ameliorated via the administration of a drug that promotes neuronal euchromatin formation. Our study provides first insight to the molecular processes by which heart failure contributes to neuronal dysfunction and point to novel therapeutic avenues to treat cognitive defects in heart failure patients.

Keyword(s): Animals (MeSH) ; Cognition (MeSH) ; Epigenesis, Genetic (MeSH) ; Gene Expression (MeSH) ; Heart Failure: genetics (MeSH) ; Humans (MeSH) ; Memory Disorders (MeSH) ; Mice (MeSH) ; cognition ; epigenetics ; heart failure ; histone ; memory impairment

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Contributing Institute(s):

1. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer 1)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2021

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Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset Islam, R. (Last author)DZNE*
Dataset: Epigenetic gene-expression links heart failure to memory impairment
Gene Expression Omnibus (2020)2020   Fulltext BibTeX | EndNote: XML, Text | RIS

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