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000157730 041__ $$aEnglish
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000157730 1001_ $$0P:(DE-2719)2810622$$aBaltruschat, Lothar$$b0$$eFirst author$$udzne
000157730 245__ $$aCircuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation.
000157730 260__ $$a[New York, NY]$$bElsevier$$c2021
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000157730 520__ $$aThe formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memory consolidation, we focus on the calyx of the Drosophila mushroom body. In this essential center, essential for olfactory learning, second- and third-order neurons connect through large synaptic microglomeruli, which we dissect at the electron microscopy level. Focusing on microglomeruli that respond to a specific odor, we reveal that appetitive long-term memory results in increased numbers of precisely those functional microglomeruli responding to the conditioned odor. Hindering memory consolidation by non-coincident presentation of odor and reward, by blocking protein synthesis, or by including memory mutants suppress these structural changes, revealing their tight correlation with the process of memory consolidation. Thus, olfactory long-term memory is associated with input-specific structural modifications in a high-order center of the fly brain.
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000157730 650_7 $$2Other$$aDrosophila
000157730 650_7 $$2Other$$aKenyon cell
000157730 650_7 $$2Other$$afunctional imaging
000157730 650_7 $$2Other$$afunctional plasticity
000157730 650_7 $$2Other$$amemory consolidation
000157730 650_7 $$2Other$$amicroglomerulus
000157730 650_7 $$2Other$$amushroom body
000157730 650_7 $$2Other$$amushroom body calyx
000157730 650_7 $$2Other$$aprojection neuron
000157730 650_7 $$2Other$$astructural plasticity
000157730 650_2 $$2MeSH$$aAnimals
000157730 650_2 $$2MeSH$$aAxons: drug effects
000157730 650_2 $$2MeSH$$aAxons: physiology
000157730 650_2 $$2MeSH$$aDrosophila melanogaster: drug effects
000157730 650_2 $$2MeSH$$aDrosophila melanogaster: physiology
000157730 650_2 $$2MeSH$$aDrosophila melanogaster: ultrastructure
000157730 650_2 $$2MeSH$$aMemory Consolidation: drug effects
000157730 650_2 $$2MeSH$$aMemory Consolidation: physiology
000157730 650_2 $$2MeSH$$aMemory, Long-Term: drug effects
000157730 650_2 $$2MeSH$$aMushroom Bodies: drug effects
000157730 650_2 $$2MeSH$$aMushroom Bodies: innervation
000157730 650_2 $$2MeSH$$aMushroom Bodies: ultrastructure
000157730 650_2 $$2MeSH$$aNerve Net: drug effects
000157730 650_2 $$2MeSH$$aNerve Net: physiology
000157730 650_2 $$2MeSH$$aNerve Net: ultrastructure
000157730 650_2 $$2MeSH$$aNeuronal Plasticity: drug effects
000157730 650_2 $$2MeSH$$aOdorants
000157730 650_2 $$2MeSH$$aOleic Acids: pharmacology
000157730 650_2 $$2MeSH$$aPheromones: pharmacology
000157730 650_2 $$2MeSH$$aSynapses: drug effects
000157730 650_2 $$2MeSH$$aSynapses: physiology
000157730 650_2 $$2MeSH$$aSynapses: ultrastructure
000157730 7001_ $$0P:(DE-2719)2812229$$aPrisco, Luigi$$b1$$udzne
000157730 7001_ $$0P:(DE-2719)2811269$$aRanft, Philipp$$b2$$udzne
000157730 7001_ $$aLauritzen, J Scott$$b3
000157730 7001_ $$aFiala, André$$b4
000157730 7001_ $$aBock, Davi D$$b5
000157730 7001_ $$0P:(DE-2719)2810271$$aTavosanis, Gaia$$b6$$eLast author$$udzne
000157730 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2021.108871$$gVol. 34, no. 11, p. 108871 -$$n11$$p108871$$tCell reports$$v34$$x2211-1247$$y2021
000157730 8564_ $$uhttps://www.sciencedirect.com/science/article/pii/S2211124721001856?via%3Dihub
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