Journal Article

DZNE-2021-01187

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation.

Baltruschat, L. (First author)DZNE* ; Prisco, L.DZNE* ; Ranft, P.DZNE* ; Lauritzen, J. S. ; Fiala, A. ; Bock, D. D. ; Tavosanis, G. (Last author)DZNE*

2021
Elsevier [New York, NY]

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Please use a persistent id in citations: doi:10.1016/j.celrep.2021.108871

Abstract: The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memory consolidation, we focus on the calyx of the Drosophila mushroom body. In this essential center, essential for olfactory learning, second- and third-order neurons connect through large synaptic microglomeruli, which we dissect at the electron microscopy level. Focusing on microglomeruli that respond to a specific odor, we reveal that appetitive long-term memory results in increased numbers of precisely those functional microglomeruli responding to the conditioned odor. Hindering memory consolidation by non-coincident presentation of odor and reward, by blocking protein synthesis, or by including memory mutants suppress these structural changes, revealing their tight correlation with the process of memory consolidation. Thus, olfactory long-term memory is associated with input-specific structural modifications in a high-order center of the fly brain.

Keyword(s): Animals (MeSH) ; Axons: drug effects (MeSH) ; Axons: physiology (MeSH) ; Drosophila melanogaster: drug effects (MeSH) ; Drosophila melanogaster: physiology (MeSH) ; Drosophila melanogaster: ultrastructure (MeSH) ; Memory Consolidation: drug effects (MeSH) ; Memory Consolidation: physiology (MeSH) ; Memory, Long-Term: drug effects (MeSH) ; Mushroom Bodies: drug effects (MeSH) ; Mushroom Bodies: innervation (MeSH) ; Mushroom Bodies: ultrastructure (MeSH) ; Nerve Net: drug effects (MeSH) ; Nerve Net: physiology (MeSH) ; Nerve Net: ultrastructure (MeSH) ; Neuronal Plasticity: drug effects (MeSH) ; Odorants (MeSH) ; Oleic Acids: pharmacology (MeSH) ; Pheromones: pharmacology (MeSH) ; Synapses: drug effects (MeSH) ; Synapses: physiology (MeSH) ; Synapses: ultrastructure (MeSH) ; Drosophila ; Kenyon cell ; functional imaging ; functional plasticity ; memory consolidation ; microglomerulus ; mushroom body ; mushroom body calyx ; projection neuron ; structural plasticity

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Contributing Institute(s):

1. Dynamics of neuronal circuits (AG Tavosanis)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2021

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Database coverage:
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