TY  - JOUR
AU  - Baltruschat, Lothar
AU  - Prisco, Luigi
AU  - Ranft, Philipp
AU  - Lauritzen, J Scott
AU  - Fiala, André
AU  - Bock, Davi D
AU  - Tavosanis, Gaia
TI  - Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation.
JO  - Cell reports
VL  - 34
IS  - 11
SN  - 2211-1247
CY  - [New York, NY]
PB  - Elsevier
M1  - DZNE-2021-01187
SP  - 108871
PY  - 2021
AB  - The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memory consolidation, we focus on the calyx of the Drosophila mushroom body. In this essential center, essential for olfactory learning, second- and third-order neurons connect through large synaptic microglomeruli, which we dissect at the electron microscopy level. Focusing on microglomeruli that respond to a specific odor, we reveal that appetitive long-term memory results in increased numbers of precisely those functional microglomeruli responding to the conditioned odor. Hindering memory consolidation by non-coincident presentation of odor and reward, by blocking protein synthesis, or by including memory mutants suppress these structural changes, revealing their tight correlation with the process of memory consolidation. Thus, olfactory long-term memory is associated with input-specific structural modifications in a high-order center of the fly brain.
KW  - Animals
KW  - Axons: drug effects
KW  - Axons: physiology
KW  - Drosophila melanogaster: drug effects
KW  - Drosophila melanogaster: physiology
KW  - Drosophila melanogaster: ultrastructure
KW  - Memory Consolidation: drug effects
KW  - Memory Consolidation: physiology
KW  - Memory, Long-Term: drug effects
KW  - Mushroom Bodies: drug effects
KW  - Mushroom Bodies: innervation
KW  - Mushroom Bodies: ultrastructure
KW  - Nerve Net: drug effects
KW  - Nerve Net: physiology
KW  - Nerve Net: ultrastructure
KW  - Neuronal Plasticity: drug effects
KW  - Odorants
KW  - Oleic Acids: pharmacology
KW  - Pheromones: pharmacology
KW  - Synapses: drug effects
KW  - Synapses: physiology
KW  - Synapses: ultrastructure
KW  - Drosophila (Other)
KW  - Kenyon cell (Other)
KW  - functional imaging (Other)
KW  - functional plasticity (Other)
KW  - memory consolidation (Other)
KW  - microglomerulus (Other)
KW  - mushroom body (Other)
KW  - mushroom body calyx (Other)
KW  - projection neuron (Other)
KW  - structural plasticity (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC8515896
C6  - pmid:33730583
DO  - DOI:10.1016/j.celrep.2021.108871
UR  - https://pub.dzne.de/record/157730
ER  -