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@ARTICLE{Baltruschat:157730,
      author       = {Baltruschat, Lothar and Prisco, Luigi and Ranft, Philipp
                      and Lauritzen, J Scott and Fiala, André and Bock, Davi D
                      and Tavosanis, Gaia},
      title        = {{C}ircuit reorganization in the {D}rosophila mushroom body
                      calyx accompanies memory consolidation.},
      journal      = {Cell reports},
      volume       = {34},
      number       = {11},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-01187},
      pages        = {108871},
      year         = {2021},
      abstract     = {The formation and consolidation of memories are complex
                      phenomena involving synaptic plasticity, microcircuit
                      reorganization, and the formation of multiple
                      representations within distinct circuits. To gain insight
                      into the structural aspects of memory consolidation, we
                      focus on the calyx of the Drosophila mushroom body. In this
                      essential center, essential for olfactory learning, second-
                      and third-order neurons connect through large synaptic
                      microglomeruli, which we dissect at the electron microscopy
                      level. Focusing on microglomeruli that respond to a specific
                      odor, we reveal that appetitive long-term memory results in
                      increased numbers of precisely those functional
                      microglomeruli responding to the conditioned odor. Hindering
                      memory consolidation by non-coincident presentation of odor
                      and reward, by blocking protein synthesis, or by including
                      memory mutants suppress these structural changes, revealing
                      their tight correlation with the process of memory
                      consolidation. Thus, olfactory long-term memory is
                      associated with input-specific structural modifications in a
                      high-order center of the fly brain.},
      keywords     = {Animals / Axons: drug effects / Axons: physiology /
                      Drosophila melanogaster: drug effects / Drosophila
                      melanogaster: physiology / Drosophila melanogaster:
                      ultrastructure / Memory Consolidation: drug effects / Memory
                      Consolidation: physiology / Memory, Long-Term: drug effects
                      / Mushroom Bodies: drug effects / Mushroom Bodies:
                      innervation / Mushroom Bodies: ultrastructure / Nerve Net:
                      drug effects / Nerve Net: physiology / Nerve Net:
                      ultrastructure / Neuronal Plasticity: drug effects /
                      Odorants / Oleic Acids: pharmacology / Pheromones:
                      pharmacology / Synapses: drug effects / Synapses: physiology
                      / Synapses: ultrastructure / Drosophila (Other) / Kenyon
                      cell (Other) / functional imaging (Other) / functional
                      plasticity (Other) / memory consolidation (Other) /
                      microglomerulus (Other) / mushroom body (Other) / mushroom
                      body calyx (Other) / projection neuron (Other) / structural
                      plasticity (Other)},
      cin          = {AG Tavosanis},
      ddc          = {610},
      cid          = {I:(DE-2719)1013018},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8515896},
      pubmed       = {pmid:33730583},
      doi          = {10.1016/j.celrep.2021.108871},
      url          = {https://pub.dzne.de/record/157730},
}