Home > Publications Database > Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation. > print

001     157730
005     20240918164037.0
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024 7 _ |a 10.1016/j.celrep.2021.108871
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024 7 _ |a 2211-1247
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024 7 _ |a 2639-1856
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082 _ _ |a 610
100 1 _ |a Baltruschat, Lothar
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245 _ _ |a Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation.
260 _ _ |a [New York, NY]
|c 2021
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520 _ _ |a The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memory consolidation, we focus on the calyx of the Drosophila mushroom body. In this essential center, essential for olfactory learning, second- and third-order neurons connect through large synaptic microglomeruli, which we dissect at the electron microscopy level. Focusing on microglomeruli that respond to a specific odor, we reveal that appetitive long-term memory results in increased numbers of precisely those functional microglomeruli responding to the conditioned odor. Hindering memory consolidation by non-coincident presentation of odor and reward, by blocking protein synthesis, or by including memory mutants suppress these structural changes, revealing their tight correlation with the process of memory consolidation. Thus, olfactory long-term memory is associated with input-specific structural modifications in a high-order center of the fly brain.
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650 _ 7 |a Drosophila
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650 _ 7 |a Kenyon cell
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650 _ 7 |a functional imaging
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650 _ 7 |a functional plasticity
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650 _ 7 |a memory consolidation
|2 Other
650 _ 7 |a microglomerulus
|2 Other
650 _ 7 |a mushroom body
|2 Other
650 _ 7 |a mushroom body calyx
|2 Other
650 _ 7 |a projection neuron
|2 Other
650 _ 7 |a structural plasticity
|2 Other
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Axons: drug effects
|2 MeSH
650 _ 2 |a Axons: physiology
|2 MeSH
650 _ 2 |a Drosophila melanogaster: drug effects
|2 MeSH
650 _ 2 |a Drosophila melanogaster: physiology
|2 MeSH
650 _ 2 |a Drosophila melanogaster: ultrastructure
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650 _ 2 |a Memory Consolidation: drug effects
|2 MeSH
650 _ 2 |a Memory Consolidation: physiology
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650 _ 2 |a Memory, Long-Term: drug effects
|2 MeSH
650 _ 2 |a Mushroom Bodies: drug effects
|2 MeSH
650 _ 2 |a Mushroom Bodies: innervation
|2 MeSH
650 _ 2 |a Mushroom Bodies: ultrastructure
|2 MeSH
650 _ 2 |a Nerve Net: drug effects
|2 MeSH
650 _ 2 |a Nerve Net: physiology
|2 MeSH
650 _ 2 |a Nerve Net: ultrastructure
|2 MeSH
650 _ 2 |a Neuronal Plasticity: drug effects
|2 MeSH
650 _ 2 |a Odorants
|2 MeSH
650 _ 2 |a Oleic Acids: pharmacology
|2 MeSH
650 _ 2 |a Pheromones: pharmacology
|2 MeSH
650 _ 2 |a Synapses: drug effects
|2 MeSH
650 _ 2 |a Synapses: physiology
|2 MeSH
650 _ 2 |a Synapses: ultrastructure
|2 MeSH
700 1 _ |a Prisco, Luigi
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700 1 _ |a Ranft, Philipp
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700 1 _ |a Lauritzen, J Scott
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700 1 _ |a Fiala, André
|b 4
700 1 _ |a Bock, Davi D
|b 5
700 1 _ |a Tavosanis, Gaia
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773 _ _ |a 10.1016/j.celrep.2021.108871
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856 4 _ |u https://www.sciencedirect.com/science/article/pii/S2211124721001856?via%3Dihub
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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